Abstract: Disclosed are apparatus and method for forming passage extending along a plane crossing an organ's volumetric region from an entry point to an opposing exit point at a surface of the organ, and for passing a tension member around the volumetric region by pulling the tension member from the exit point to the entry point through the passage. The apparatus can include a rigid outer tube with a tip for penetrating the organ and reach a penetration depth; an inner needle with elastic body configured to pass straightened through outer tube lumen and to partially protrude and voluntarily flex to a curved form greater than the diameter of the volumetric region; and a tension member passer with a pulling portion for engaging with portion of tension member and for pulling the tension member when withdrawn.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting errors in a computation performed by a quantum computer. In one aspect, a method comprises obtaining error correction data for each of a plurality of time steps during the computation; and processing a respective input for each of a plurality of updating time steps using one or more machine learning decoder models to generate a prediction of whether an error occurred in the computation, wherein each updating time step corresponds to one or more of the time steps and wherein the respective input for each of the plurality of updating time steps is generated from the error correction data for the corresponding one or more time steps.

Abstract: Disclosed herein are an exemplary apparatus, system, and methods (e.g., Tactical Passive RFID transponder gloves with Morphological Actuation) comprising a glove made predominately of a resistive fabric that varies resistance per degree of deformation; comprising near field communication RFID tag readers, and a controller coupled to the glove to evaluate the varied resistance. A method of classifying RFID tags is also disclosed.

Abstract: A method is disclosed for providing autocomplete suggestions for a navigation text box. The method includes receiving an input in the navigation text box and obtaining candidate navigation suggestions from a retrieval source. Respective signals are obtained for the candidate navigation suggestions, and respective probability scores are obtained by providing the input, candidate navigation suggestions, and signals to a navigation suggestion ranking model. The probability scores reflect a prediction of the likelihood of selection. Based on their respective probability scores, at least some candidate navigation suggestions are provided as autocomplete suggestions for the input. This method enhances user experience by offering relevant and personalized navigation suggestions in real-time, improving efficiency and accuracy in navigation tasks.

Abstract: Disclosed are a surgical tunneler, kits comprising the surgical tunneler, and methods of use thereof, for implanting access lines. The surgical tunneler includes a rigid elongated body, a rounded or pointed distal tip configured to dissect between tissue layers and/or to form a surgical tunnel when pushed subcutaneously in the body, and a guidewire capturing portion provided proximally to the distal tip. The guidewire capturing portion is configured to capture and/or fasten onto a target portion of an elastic stiff guidewire from within a body of a subject, such that the guidewire can be drawn with the surgical tunneler by way of pulling from the target portion thereof. In some embodiments, the surgical tunneler is capable of locally manipulating, folding and/or fixedly deforming a chosen portion of the elastic stiff guidewire, when guidewire capturing portion fasten onto the target portion.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: Methods, systems, and apparatus for enhanced decoding using in-phase and quadrature information. In one aspect, a method includes obtaining in-phase and quadrature values for multiple measurement operations in a quantum error correction code for a quantum computation; classifying measurement outcomes of the multiple measurement operations using respective in-phase and quadrature values; generating a detector graph of nodes and edges, wherein the detector graph labels detection events that occur in the classified measurement outcomes; assigning weights to the edges of the detector graph using posterior probability distributions of the classified measurement outcomes to generate a weighted detector graph; and executing a decoding process on the weighted detector graph to compute a decoding output of the decoding process, wherein the decoding output predicts an occurrence of errors in the quantum computation.

Abstract: A split-tip catheter and methods for deploying a split-tip catheter in a right atrium are provided. The catheter is configured with a distal portion including a first and a second distal end regions elastically divergable from alignment along a splitting plane to regain a relaxed configuration. The first distal end region terminates in a first tip having a first forward opening, and the second distal end region terminates in a second tip having a second forward opening. Catheter deployment may include directing the first forward opening generally towards an anterior right atrium wall portion and applying the first forward opening to withdraw blood from the right atrium.

Abstract: A split-tip catheter and methods for deploying a split-tip catheter in a right atrium are provided. The catheter is configured with a distal portion including a first and a second distal end regions elastically divergable from alignment along a splitting plane to regain a relaxed configuration. The first distal end region terminates in a first tip having a first forward opening, and the second distal end region terminates in a second tip having a second forward opening. Catheter deployment may include directing the first forward opening generally towards an anterior right atrium wall portion and applying the first forward opening to withdraw blood from the right atrium.

Abstract: Provided herein is a combination therapy and methods of using such combination therapy to treat diseases or disorders associated with PKC and c-MET.

Abstract: Disclosed are a surgical tunneler, kits comprising the surgical tunneler, and methods of use thereof, for implanting access lines. The surgical tunneler includes a rigid elongated body, a rounded or pointed distal tip configured to dissect between tissue layers and/or to form a surgical tunnel when pushed subcutaneously in the body, and a guidewire capturing portion provided proximally to the distal tip. The guidewire capturing portion is configured to capture and/or fasten onto a target portion of an elastic stiff guidewire from within a body of a subject, such that the guidewire can be drawn with the surgical tunneler by way of pulling from the target portion thereof. In some embodiments, the surgical tunneler is capable of locally manipulating, folding and/or fixedly deforming a chosen portion of the elastic stiff guidewire, when guidewire capturing portion fasten onto the target portion.

Abstract: An embolization microcatheter having an elongated microcatheter body configured for passing therein a suspension of particles suspended in a suspension fluid; and a microcatheter head connected to a distal end of said microcatheter body and comprising a proximal head section and a distal head section, wherein the proximal head section includes a proximal wall forming a proximal section lumen, the proximal wall having a plurality of through-holes, wherein the distal head section includes a distal wall forming a distal section lumen, and a suspension delivery opening at a distal end of the distal end section; wherein the distal section is devoid of through-holes, and wherein each of the plurality of through-holes are shaped and/or sized to allow passage therethrough of the suspension fluid while blocking passage of the particles suspended therein.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: Provided herein is a combination therapy and methods of using such combination therapy to treat diseases or disorders associated with PKC and MEK.

Abstract: The invention relates to biomimetic adhesive compositions emulating mussel adhesive proteins, wherein multiple chains of a copolymer are interlinked via specific hydrogen bonds and/or ligand-metal-ligand bonds, which serve as sacrificial breakable bonds upon mechanical stress and thereby effectively dissipate the mechanical energy. Accordingly, toughened adhesive compositions with improved ductility and strength may be obtained.

Abstract: Disclosed are vascular occluder, kit and method of use thereof. The vascular occluder includes an occluder body extending longitudinally between an occluder body distal end and an occluder body proximal end. The occluder body is elastically compressible longitudinally from a preliminary deployed configuration to a compressed deployed configuration. Vascular occluder includes a tension member configured to tether the occluder body proximal end to the occluder body distal end and to tighten therebetween when the occluder body is in the compressed deployed configuration. The occluder body includes a proximal tubular body segment and a distal tubular body segment, and when in the compressed deployed configuration, the proximal tubular body segment is located inside of, and/or provides structural support to, the distal tubular body segment.

Abstract: A vascular access wire is disclosed. The vascular access wire includes an elongated core member and a distal tip. The Distal tip comprising a crank configured with a crank distal surface and a crank center of rotation. The crank is configured to rotate about the crank center of rotation when the core member is sufficiently loaded axially and when the crank distal surface is pressed against a wall of a target blood vessel, for triggering or affecting a deflecting and/or a deforming of the core member proximally to the crank.

Abstract: Disclosed are implant and method for gradually restricting vascular blood flow in a host blood vessel. The implant N comprising an elongated body and at least one holding member. Implant body comprising a flow restricting portion enclosing a variable minimal internal diameter. Holding member is configured for restraining implant body to maintain the variable minimal internal diameter in a first minimal internal diameter, and to physically yield voluntarily after a first predetermined average duration of being continuously subjected to internal human body conditions, thereby releasing and allowing the implant body to elastically deform voluntarily such that the variable minimal internal diameter changes to a second minimal internal diameter, smaller than the first minimal internal diameter.

Abstract: Vascular occluder and methods for occluding a passage are provided. The vascular occluder comprises an elongated occluder body with an occluding section, and a tension member connected with one end thereof to occluder body. Occluding section forms a tubular bellows-like shaped structure comprising a plurality of bellows sections when in an elastically relaxed configuration, is elastically stretchable longitudinally from the elastically relaxed configuration to a delivery configuration, and elastically compressible longitudinally from the elastically relaxed configuration, by way of applying tension to the tension member, to a fixed deployed configuration.

Abstract: The present disclosure provides a process of separating designated oligomeric compounds from sample solutions comprising at least one contaminant In certain embodiments, the designated oligomeric compounds comprise a modified oligonucleotide and a conjugate group comprising at least one carbohydrate cluster. In certain embodiments, the present disclosure provides HPLC conditions that increase the separation of a designated oligomeric compound from at least one contaminant compared to standard HPLC conditions.