Abstract: Disclosed are vascular occluder, kit and method of use thereof. The vascular occluder includes an occluder body extending longitudinally between an occluder body distal end and an occluder body proximal end. The occluder body is elastically compressible longitudinally from a preliminary deployed configuration to a compressed deployed configuration. Vascular occluder includes a tension member configured to tether the occluder body proximal end to the occluder body distal end and to tighten therebetween when the occluder body is in the compressed deployed configuration. The occluder body includes a proximal tubular body segment and a distal tubular body segment, and when in the compressed deployed configuration, the proximal tubular body segment is located inside of, and/or provides structural support to, the distal tubular body segment.

Abstract: A vascular access wire is disclosed. The vascular access wire includes an elongated core member and a distal tip. The Distal tip comprising a crank configured with a crank distal surface and a crank center of rotation. The crank is configured to rotate about the crank center of rotation when the core member is sufficiently loaded axially and when the crank distal surface is pressed against a wall of a target blood vessel, for triggering or affecting a deflecting and/or a deforming of the core member proximally to the crank.

Abstract: A filter module for filtering fuel in an engine system includes a primary filter, a secondary filter, and a module housing. A drain valve is movable between a closed position blocking a drain port in the module housing, and an open position. A service valve assembly is positioned at least partially within a cross passage in the module housing and adjustable from a closed configuration blocking a primary-side fuel passage from a secondary-side fuel passage in the module housing, to an open configuration, to drain fluids from the filter module by way of the single drain port.

Abstract: Disclosed are implant and method for gradually restricting vascular blood flow in a host blood vessel. The implant N comprising an elongated body and at least one holding member. Implant body comprising a flow restricting portion enclosing a variable minimal internal diameter. Holding member is configured for restraining implant body to maintain the variable minimal internal diameter in a first minimal internal diameter, and to physically yield voluntarily after a first predetermined average duration of being continuously subjected to internal human body conditions, thereby releasing and allowing the implant body to elastically deform voluntarily such that the variable minimal internal diameter changes to a second minimal internal diameter, smaller than the first minimal internal diameter.

Abstract: Vascular occluder and methods for occluding a passage are provided. The vascular occluder comprises an elongated occluder body with an occluding section, and a tension member connected with one end thereof to occluder body. Occluding section forms a tubular bellows-like shaped structure comprising a plurality of bellows sections when in an elastically relaxed configuration, is elastically stretchable longitudinally from the elastically relaxed configuration to a delivery configuration, and elastically compressible longitudinally from the elastically relaxed configuration, by way of applying tension to the tension member, to a fixed deployed configuration.

Abstract: The present disclosure provides a process of separating designated oligomeric compounds from sample solutions comprising at least one contaminant In certain embodiments, the designated oligomeric compounds comprise a modified oligonucleotide and a conjugate group comprising at least one carbohydrate cluster. In certain embodiments, the present disclosure provides HPLC conditions that increase the separation of a designated oligomeric compound from at least one contaminant compared to standard HPLC conditions.

Abstract: In one example, a memory having instructions thereon that when executed cause a 3D printing system to repeatedly form each of multiple successive layers of powdered build material on a platform and apply a functional agent to build material in each layer, create a pressure difference across a thickness of build material on the platform, and increase the pressure difference over an extent of build material on the platform as the build material on the platform gets thicker.

Abstract: Devices, methods and kits for preventing or reducing non-target microparticles deposition and embolization, in conjunction with delivering microparticles (e.g., embolization material) via a blood vessel to a target bodily part. Applicable for entrapping infiltrated microparticles within heart right atrium. Entrapping device includes: filter; and filter collapsing mechanism sized for positioning in catheter lumen of a filter delivering catheter, and having proximal end actuatable from outside of subject. Filter configured for positioning within heart right atrium, for self-expanding and covering right atrium inlet opening, and configured, when expanded, to collect embolic material delivered to target organ and infiltrated into outflow vessel thereof draining to right atrium.

Abstract: A glass comprising titania and silica is disclosed. A plot of average hydroxyl concentration of each segment of a plurality of segments vs. distance along the glass is provided by: y=Ax2+Bx+C, wherein A (in ppm/mm2) is in a range from about 0.0 to about ?0.1, B (in ppm/mm) is in a range from about ?10 to about 10, C (in ppm) is about 450 or less, y is the average hydroxyl concentration (in ppm), and x is distance (in mm) such that the hydroxyl concentration of each segment is measured using a Fourier transform infrared spectroscopy in transmission and the plot extends a distance of about 50 mm or more along the glass.

Abstract: A vascular access wire is disclosed. The vascular access wire includes an elongated core member and a distal tip. The Distal tip comprising a crank configured with a crank distal surface and a crank center of rotation. The crank is configured to rotate about the crank center of rotation when the core member is sufficiently loaded axially and when the crank distal surface is pressed against a wall of a target blood vessel, for triggering or affecting a deflecting and/or a deforming of the core member proximally to the crank.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: The invention relates to biomimetic adhesive compositions emulating mussel adhesive proteins, wherein multiple chains of a copolymer are interlinked via specific hydrogen bonds and/or ligand-metal-ligand bonds, which serve as sacrificial breakable bonds upon mechanical stress and thereby effectively dissipate the mechanical energy. Accordingly, toughened adhesive compositions with improved ductility and strength may be obtained.

Abstract: Infusion balloon catheter with fortified proximal infusion outlet port, and manufacturing thereof. Infusion balloon catheter includes: inflatable balloon member; shaft having distal end attached to balloon member, and shaft wall enclosing: first lumen providing passage to balloon inflation fluid, and second lumen providing passage to infusion fluid and guidewire; and bending-resistant insert member housed in second lumen and located proximally to balloon member, insert member is affixed to, and conforms to shape of, shaft inner wall surface, and includes one or more opening(s). Shaft wall has infusion outlet port located along, and providing opening to, second lumen proximally to balloon member. Insert opening(s) is/are in direct fluid communication with infusion outlet port whose cross-sectional area is larger than that of infusion inlet opening. Bending-resistant insert member provides fortifying structural support to shaft wall portion surrounding infusion outlet port.

Abstract: Vascular access kit comprising a guidewire and a needle. The guidewire includes elastic core member ending with guidewire tip segment. Guidewire tip segment comprising widening, guidewire tip rear portion extending distally to the widening, and guidewire tip front portion extending distally from the widening. The needle comprising a beveled opening greater in length than guidewire tip front portion. Guidewire tip rear portion includes a flexing portion configured for causing localized buckling and/or bending for inclining guidewire tip front portion relative to guidewire tip rear portion, in needle beveled opening, when the core member is axially compressed.

Abstract: Disclosed are a subcutaneous port and method of implantation thereof. The subcutaneous port comprising a rigid inner member and an outer member comprising of flexible material connected to the inner member along at least one lateral periphery portion of the inner member, thereby forming a predetermined spatial shape of the subcutaneous port when in an elastically relaxed state. The subcutaneous port is configured to squeeze into a subcutaneous void when pushed through a surgical opening greater than a maximal cross-sectional circumference of the inner member and smaller than a maximal cross-sectional circumference of the predetermined spatial shape.

Abstract: An infusion apparatus comprises a reservoir and a catheter having a proximal portion coupled to the reservoir. The apparatus comprises at least one antimicrobial barrier. The antimicrobial barrier may be configured to elute an antimicrobial agent into the surrounding area, such as into a fibrin sheath or clot on the external surface of the catheter.

Abstract: Vascular access catheter comprising elongated tubular catheter body enclosing a lumen. Catheter body includes catheter tip ending with a catheter distal end and comprising a distal edge at the catheter distal end surrounding an opening opened to the lumen. he distal edge includes a front edge portion spanning a top portion of the opening and an inclined edge portion spanning a bottom portion of the opening and inclining proximally away from the front edge portion, relative to a longitudinal axis of the catheter body. The vascular access catheter can be provided in a vascular access kit further comprising access needle with hollow needle body and beveled tip ending with sharp needle edge.

Abstract: In one example, a device for dispensing build material powder in an additive manufacturing machine includes a first dispenser including a first scoop rotatable in a first direction to scoop build material powder into the first dispenser, a second dispenser including a second scoop rotatable in a second direction opposite the first direction to scoop build material powder into the second dispenser, and a leveler between the first dispenser and the second dispenser.

Abstract: An embolization microcatheter is configured to deliver embolization particles to a target area and minimize or prevent embolization of a non-target area. The microcatheter includes a section, located between the distal and proximal ends of the microcatheter, having a skeleton formed of braided wires and a polymeric layer intercalated into and/or overlaying the skeleton. This section includes a plurality of axial slits, each slit having a smallest cross-sectional dimension configured to prevent outflow of the embolization particles.

Abstract: A microcatheter comprising an inner layer, a strike layer and an outer layer and a braided skeleton located between the inner layer and the outer layer, wherein the inner layer is made of Polytetrafluoroethylene (PTFE) and has a thickness of 0.0015 inch or less, wherein the strike layer includes a polyether block amide and has a thickness of 0.001 inch or less, and wherein a distal portion of said outer layer is made of polycarbonate-based thermoplastic polyurethane having a shore of 90A or below.