Abstract: Blood flow affecting implant and implantation thereof in superior vena cava, optionally including disintegration of endothelium layer and inducing tissue ingrowth within implant. Implant includes elongated body with optional tubular inner layer forming orifice, shapeable to final orifice diameter for restricting blood flowing therethrough to chosen average flow rate; and/or tubular outer layer provided coaxially around inner layer. Outer layer is formed of second material provided in elastically deformable state for facilitating elastic radial self¬expanding from collapsed diameter up to relaxed maximal expanded diameter greater than diameter of inner wall portion of superior vena cava. Inner layer is formed of first material, in plastically or elastically deformable state.

Abstract: Disclosed are apparatus and method for forming passage extending along a plane crossing an organ's volumetric region from an entry point to an opposing exit point at a surface of the organ, and for passing a tension member around the volumetric region by pulling the tension member from the exit point to the entry point through the passage. The apparatus can include a rigid outer tube with a tip for penetrating the organ and reach a penetration depth; an inner needle with elastic body configured to pass straightened through outer tube lumen and to partially protrude and voluntarily flex to a curved form greater than the diameter of the volumetric region; and a tension member passer with a pulling portion for engaging with portion of tension member and for pulling the tension member when withdrawn.

Abstract: Disclosed are a surgical tunneler, kits comprising the surgical tunneler, and methods of use thereof, for implanting access lines. The surgical tunneler includes a rigid elongated body, a rounded or pointed distal tip configured to dissect between tissue layers and/or to form a surgical tunnel when pushed subcutaneously in the body, and a guidewire capturing portion provided proximally to the distal tip. The guidewire capturing portion is configured to capture and/or fasten onto a target portion of an elastic stiff guidewire from within a body of a subject, such that the guidewire can be drawn with the surgical tunneler by way of pulling from the target portion thereof. In some embodiments, the surgical tunneler is capable of locally manipulating, folding and/or fixedly deforming a chosen portion of the elastic stiff guidewire, when guidewire capturing portion fasten onto the target portion.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: A split-tip catheter and methods for deploying a split-tip catheter in a right atrium are provided. The catheter is configured with a distal portion including a first and a second distal end regions elastically divergable from alignment along a splitting plane to regain a relaxed configuration. The first distal end region terminates in a first tip having a first forward opening, and the second distal end region terminates in a second tip having a second forward opening. Catheter deployment may include directing the first forward opening generally towards an anterior right atrium wall portion and applying the first forward opening to withdraw blood from the right atrium.

Abstract: A split-tip catheter and methods for deploying a split-tip catheter in a right atrium are provided. The catheter is configured with a distal portion including a first and a second distal end regions elastically divergable from alignment along a splitting plane to regain a relaxed configuration. The first distal end region terminates in a first tip having a first forward opening, and the second distal end region terminates in a second tip having a second forward opening. Catheter deployment may include directing the first forward opening generally towards an anterior right atrium wall portion and applying the first forward opening to withdraw blood from the right atrium.

Abstract: Disclosed are a surgical tunneler, kits comprising the surgical tunneler, and methods of use thereof, for implanting access lines. The surgical tunneler includes a rigid elongated body, a rounded or pointed distal tip configured to dissect between tissue layers and/or to form a surgical tunnel when pushed subcutaneously in the body, and a guidewire capturing portion provided proximally to the distal tip. The guidewire capturing portion is configured to capture and/or fasten onto a target portion of an elastic stiff guidewire from within a body of a subject, such that the guidewire can be drawn with the surgical tunneler by way of pulling from the target portion thereof. In some embodiments, the surgical tunneler is capable of locally manipulating, folding and/or fixedly deforming a chosen portion of the elastic stiff guidewire, when guidewire capturing portion fasten onto the target portion.

Abstract: An embolization microcatheter having an elongated microcatheter body configured for passing therein a suspension of particles suspended in a suspension fluid; and a microcatheter head connected to a distal end of said microcatheter body and comprising a proximal head section and a distal head section, wherein the proximal head section includes a proximal wall forming a proximal section lumen, the proximal wall having a plurality of through-holes, wherein the distal head section includes a distal wall forming a distal section lumen, and a suspension delivery opening at a distal end of the distal end section; wherein the distal section is devoid of through-holes, and wherein each of the plurality of through-holes are shaped and/or sized to allow passage therethrough of the suspension fluid while blocking passage of the particles suspended therein.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: Disclosed are vascular occluder, kit and method of use thereof. The vascular occluder includes an occluder body extending longitudinally between an occluder body distal end and an occluder body proximal end. The occluder body is elastically compressible longitudinally from a preliminary deployed configuration to a compressed deployed configuration. Vascular occluder includes a tension member configured to tether the occluder body proximal end to the occluder body distal end and to tighten therebetween when the occluder body is in the compressed deployed configuration. The occluder body includes a proximal tubular body segment and a distal tubular body segment, and when in the compressed deployed configuration, the proximal tubular body segment is located inside of, and/or provides structural support to, the distal tubular body segment.

Abstract: A vascular access wire is disclosed. The vascular access wire includes an elongated core member and a distal tip. The Distal tip comprising a crank configured with a crank distal surface and a crank center of rotation. The crank is configured to rotate about the crank center of rotation when the core member is sufficiently loaded axially and when the crank distal surface is pressed against a wall of a target blood vessel, for triggering or affecting a deflecting and/or a deforming of the core member proximally to the crank.

Abstract: Disclosed are implant and method for gradually restricting vascular blood flow in a host blood vessel. The implant N comprising an elongated body and at least one holding member. Implant body comprising a flow restricting portion enclosing a variable minimal internal diameter. Holding member is configured for restraining implant body to maintain the variable minimal internal diameter in a first minimal internal diameter, and to physically yield voluntarily after a first predetermined average duration of being continuously subjected to internal human body conditions, thereby releasing and allowing the implant body to elastically deform voluntarily such that the variable minimal internal diameter changes to a second minimal internal diameter, smaller than the first minimal internal diameter.

Abstract: Vascular occluder and methods for occluding a passage are provided. The vascular occluder comprises an elongated occluder body with an occluding section, and a tension member connected with one end thereof to occluder body. Occluding section forms a tubular bellows-like shaped structure comprising a plurality of bellows sections when in an elastically relaxed configuration, is elastically stretchable longitudinally from the elastically relaxed configuration to a delivery configuration, and elastically compressible longitudinally from the elastically relaxed configuration, by way of applying tension to the tension member, to a fixed deployed configuration.

Abstract: Devices, methods and kits for preventing or reducing non-target microparticles deposition and embolization, in conjunction with delivering microparticles (e.g., embolization material) via a blood vessel to a target bodily part. Applicable for entrapping infiltrated microparticles within heart right atrium. Entrapping device includes: filter; and filter collapsing mechanism sized for positioning in catheter lumen of a filter delivering catheter, and having proximal end actuatable from outside of subject. Filter configured for positioning within heart right atrium, for self-expanding and covering right atrium inlet opening, and configured, when expanded, to collect embolic material delivered to target organ and infiltrated into outflow vessel thereof draining to right atrium.

Abstract: A vascular access wire is disclosed. The vascular access wire includes an elongated core member and a distal tip. The Distal tip comprising a crank configured with a crank distal surface and a crank center of rotation. The crank is configured to rotate about the crank center of rotation when the core member is sufficiently loaded axially and when the crank distal surface is pressed against a wall of a target blood vessel, for triggering or affecting a deflecting and/or a deforming of the core member proximally to the crank.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: Infusion balloon catheter with fortified proximal infusion outlet port, and manufacturing thereof. Infusion balloon catheter includes: inflatable balloon member; shaft having distal end attached to balloon member, and shaft wall enclosing: first lumen providing passage to balloon inflation fluid, and second lumen providing passage to infusion fluid and guidewire; and bending-resistant insert member housed in second lumen and located proximally to balloon member, insert member is affixed to, and conforms to shape of, shaft inner wall surface, and includes one or more opening(s). Shaft wall has infusion outlet port located along, and providing opening to, second lumen proximally to balloon member. Insert opening(s) is/are in direct fluid communication with infusion outlet port whose cross-sectional area is larger than that of infusion inlet opening. Bending-resistant insert member provides fortifying structural support to shaft wall portion surrounding infusion outlet port.

Abstract: Vascular access kit comprising a guidewire and a needle. The guidewire includes elastic core member ending with guidewire tip segment. Guidewire tip segment comprising widening, guidewire tip rear portion extending distally to the widening, and guidewire tip front portion extending distally from the widening. The needle comprising a beveled opening greater in length than guidewire tip front portion. Guidewire tip rear portion includes a flexing portion configured for causing localized buckling and/or bending for inclining guidewire tip front portion relative to guidewire tip rear portion, in needle beveled opening, when the core member is axially compressed.

Abstract: Disclosed are a subcutaneous port and method of implantation thereof. The subcutaneous port comprising a rigid inner member and an outer member comprising of flexible material connected to the inner member along at least one lateral periphery portion of the inner member, thereby forming a predetermined spatial shape of the subcutaneous port when in an elastically relaxed state. The subcutaneous port is configured to squeeze into a subcutaneous void when pushed through a surgical opening greater than a maximal cross-sectional circumference of the inner member and smaller than a maximal cross-sectional circumference of the predetermined spatial shape.

Abstract: An infusion apparatus comprises a reservoir and a catheter having a proximal portion coupled to the reservoir. The apparatus comprises at least one antimicrobial barrier. The antimicrobial barrier may be configured to elute an antimicrobial agent into the surrounding area, such as into a fibrin sheath or clot on the external surface of the catheter.