Patents by Inventor Michael Gait

Michael Gait has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATE AND USES THEREOF
    Publication number: 20220275372
    Abstract: The present invention relates to conjugates formed from a cell-penetrating peptide carrier linked to a therapeutic molecule, wherein the peptide carrier is defined by specific domains and the therapeutic molecule is a nucleic acid formed of trinucleotide repeats. The present invention further relates to the use of such a conjugate in methods of treatment or as a medicament, especially in the treatment of trinucleotide repeat disorders such as myotonic dystrophy (DM1).
    Type: Application
    Filed: August 7, 2020
    Publication date: September 1, 2022
    Applicants: OXFORD UNIVERSITY INNOVATION LIMITED, UNITED KINGDOM RESEARCH AND INNOVATION, ASSOCIATION INSTITUT DE MYOLOGIE, INSERM (INSTITUT NATONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), SORBONNE UNIVERSITE
    Inventors: Matthew Wood, Miguel Varela, Ashling Holland, Richard Raz, Denis Furling, Arnaud Klein, Michael Gait
  • LINKERS
    Publication number: 20220125934
    Abstract: The present invention relates to linkers for connecting a carrier molecule to a therapeutic molecule to form a conjugate, in particular linkers formed of amino acids such as glutamic acid, succinic acid, and gamma-aminobutyric acid. The present invention further relates to a conjugate comprising a linker of the invention, and the use of said conjugate in the treatment of various diseases.
    Type: Application
    Filed: December 6, 2019
    Publication date: April 28, 2022
    Inventors: Richard Raz, Matthew Wood, Caroline Godfrey, Graham McClorey, Subhashis Banerjee, Michael Gait, Miguel Varela, Ashling Holland
  • CELL PENETRATING MOLECULE
    Publication number: 20220090066
    Abstract: The present invention relates to cell penetrating molecules comprising two oligonucleotide cargo molecules.
    Type: Application
    Filed: November 22, 2020
    Publication date: March 24, 2022
    Inventors: Matthew Wood, Graham McClorey, Michael Gait, Peter Jarver, Amer Salah, Fazel Shabanpoor
  • CELL PENETRATING PEPTIDES
    Publication number: 20220041662
    Abstract: The present invention relates to peptides, in particular cell penetrating peptides, of 40 amino acid residues or less comprising at least one directly glycosylated amino residue and one or more arginine rich arm domains, and to conjugates of such cell penetrating peptides with a therapeutic molecule. The present invention further relates to the use of the peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders of the central nervous system.
    Type: Application
    Filed: April 23, 2021
    Publication date: February 10, 2022
    Applicants: Oxford University Innovation Limited, United Kingdom Research and Innovation
    Inventors: Matthew Wood, Suzan Hammond, Melissa Bowerman, Michael Gait, Frank Adendroth, Graham McClorey
  • CELL-PENETRATING PEPTIDES
    Publication number: 20210299263
    Abstract: The present invention relates to peptides, in particular cell-penetrating peptides, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.
    Type: Application
    Filed: August 9, 2019
    Publication date: September 30, 2021
    Inventors: Matthew Wood, Raquel Manzano, Caroline Godfrey, Graham McClorey, Richard Raz, Michael Gait, Andrey Arzumanov, Liz O'Donovan, Gareth Hazell, Ashling Holland, Miguel Varela
  • CELL PENETRATING PEPTIDES
    Publication number: 20200131231
    Abstract: The present invention relates to peptides, in particular cell penetrating peptides, of 40 amino acid residues or less comprising at least one directly glycosylated amino residue and one or more arginine rich arm domains, and to conjugates of such cell penetrating peptides with a therapeutic molecule. The present invention further relates to the use of the peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders of the central nervous system. page.
    Type: Application
    Filed: February 16, 2018
    Publication date: April 30, 2020
    Inventors: Matthew Wood, Suzan Hammond, Melissa Bowerman, Michael Gait, Frank Adendroth, Graham McClorey
  • CELL PENETRATING MOLECULE
    Publication number: 20180334673
    Abstract: The present invention relates to cell penetrating molecules comprising two oligonucleotide cargo molecules.
    Type: Application
    Filed: December 1, 2015
    Publication date: November 22, 2018
    Inventors: Matthew Wood, Graham McClorey, Michael Gait, Peter Jarver, Amer Salah, Fazel Shabanpoor
  • HYBRID INTERFERING RNA
    Publication number: 20120136040
    Abstract: The invention relates to a hybrid interfering RNA molecule comprising a duplex RNA and a single stranded DNA molecule and its use in the ablation of mRNA and in polymerase chain reactions.
    Type: Application
    Filed: October 11, 2011
    Publication date: May 31, 2012
    Inventors: Ann Josephine Milner, Michael Gait, Ming Jiang, Andrei Arzumanov
  • Hybrid interfering RNA
    Patent number: 8067572
    Abstract: The invention relates to a hybrid interfering RNA molecule comprising a duplex RNA and a single stranded DNA molecule and its use in the ablation of mRNA and in polymerase chain reactions.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: November 29, 2011
    Assignee: The University of York
    Inventors: Josephine Anne Milner, Michael Gait, Ming Jiang, Andrei Arzumanov
  • Hybrid Interfering Rna
    Publication number: 20090012022
    Abstract: The invention relates to a hybrid interfering RNA molecule comprising a duplex RNA and a single stranded DNA molecule and its use in the ablation of mRNA and in polymerase chain reactions.
    Type: Application
    Filed: May 24, 2006
    Publication date: January 8, 2009
    Inventors: Josephine Anne Milner, Michael Gait, Ming Jiang, Andrei Arzumanov
  • Phosphoramidite derivatives, their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
    Patent number: 5567811
    Abstract: Phosphoramidite derivatives of formula (V), ##STR1## wherein X is biotin and Y is a protecting group. There may be a linker arm, of variable length, between X and the rest of the molecule. Examples of the protecting group Y include 4,4'-dimethoxytrityl, trifluoroacetyl and fluorenylmethoxycarbonyl (Fmoc). The phosphoramidite derivatives are useful in single or multiple labelling of synthetic oligonucleotides. Process for the preparation of these phosphoramidite derivatives are also disclosed.
    Type: Grant
    Filed: November 3, 1992
    Date of Patent: October 22, 1996
    Assignee: Amersham International plc
    Inventors: Konrad Misiura, Michael Gait