Patents by Inventor Michael Gale
Michael Gale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11673802Abstract: A hydrogen storage assembly includes at least one wafer formed of a substrate material that produces metal hydride when exposed to a hydrogen-rich carrier fluid. The wafer can be supported by a housing and arranged so that the hydrogen-rich carrier fluid can flow over a reaction surface of the wafer. At least one heating element can be arranged to transfer heat to the wafer to attain an operating temperature suitable for hydrogen charging on the reaction surface. A de-activation material may be provided on the reaction surface for inhibiting formation of surface oxide that impedes hydrogen absorption during charging and hydrogen desorption during discharging. The at least one wafer can include a plurality of monolithic plate wafers spaced apart about a central axis of the assembly. The at least one wafer can include a plurality of monolithic disc wafers in at least one stacked arrangement.Type: GrantFiled: October 29, 2020Date of Patent: June 13, 2023Assignee: Atomic Energy of Canada Limited / Énergie Atomique du Canada LimitèeInventors: Randy W. L. Fong, James Patrick, Michael Gale
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Publication number: 20230053634Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpre S1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.Type: ApplicationFiled: July 1, 2022Publication date: February 23, 2023Inventors: Edward A. CLARK, Che-Leung LAW, Deborah FULLER, Michael GALE
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Patent number: 11389532Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.Type: GrantFiled: November 15, 2018Date of Patent: July 19, 2022Assignees: University of Washington, Abacus Bioscience, Inc.Inventors: Edward A. Clark, Che-Leung Law, Deborah Fuller, Michael Gale
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Publication number: 20210047179Abstract: A hydrogen storage assembly includes at least one wafer formed of a substrate material that produces metal hydride when exposed to a hydrogen-rich carrier fluid. The wafer can be supported by a housing and arranged so that the hydrogen-rich carrier fluid can flow over a reaction surface of the wafer. At least one heating element can be arranged to transfer heat to the wafer to attain an operating temperature suitable for hydrogen charging on the reaction surface. A de-activation material may be provided on the reaction surface for inhibiting formation of surface oxide that impedes hydrogen absorption during charging and hydrogen desorption during discharging. The at least one wafer can include a plurality of monolithic plate wafers spaced apart about a central axis of the assembly. The at least one wafer can include a plurality of monolithic disc wafers in at least one stacked arrangement.Type: ApplicationFiled: October 29, 2020Publication date: February 18, 2021Inventors: Randy W.L. Fong, James Patrick, Michael Gale
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Patent number: 10850979Abstract: A hydrogen storage assembly includes at least one wafer formed of a substrate material that produces metal hydride when exposed to a hydrogen-rich carrier fluid. The wafer can be supported by a housing and arranged so that the hydrogen-rich carrier fluid can flow over a reaction surface of the wafer. At least one heating element can be arranged to transfer heat to the wafer to attain an operating temperature suitable for hydrogen charging on the reaction surface. A de-activation material may be provided on the reaction surface for inhibiting formation of surface oxide that impedes hydrogen absorption during charging and hydrogen desorption during discharging. The at least one wafer can include a plurality of monolithic plate wafers spaced apart about a central axis of the assembly. The at least one wafer can include a plurality of monolithic disc wafers in at least one stacked arrangement.Type: GrantFiled: December 7, 2016Date of Patent: December 1, 2020Assignee: ATOMIC ENERGY OF CANADA LIMITED / ÉNERGIE ATOMIQUE DU CANADA LIMITÉEInventors: Randy W. L. Fong, James Patrick, Michael Gale
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Publication number: 20200345838Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.Type: ApplicationFiled: November 15, 2018Publication date: November 5, 2020Inventors: Edward A. CLARK, Che-Leung LAW, Deborah FULLER, Michael GALE
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Publication number: 20180354786Abstract: A hydrogen storage assembly includes at least one wafer formed of a substrate material that produces metal hydride when exposed to a hydrogen-rich carrier fluid. The wafer can be supported by a housing and arranged so that the hydrogen-rich carrier fluid can flow over a reaction surface of the wafer. At least one heating element can be arranged to transfer heat to the wafer to attain an operating temperature suitable for hydrogen charging on the reaction surface. A de-activation material may be provided on the reaction surface for inhibiting formation of surface oxide that impedes hydrogen absorption during charging and hydrogen desorption during discharging. The at least one wafer can include a plurality of monolithic plate wafers spaced apart about a central axis of the assembly. The at least one wafer can include a plurality of monolithic disc wafers in at least one stacked arrangement.Type: ApplicationFiled: December 7, 2016Publication date: December 13, 2018Applicant: ATOMIC ENERGY OF CANADA LIMITED / ÉNERGIE ATOMIQUE DU CANADA LIMITÉEInventors: Randy W.L. Fong, James Patrick, Michael Gale
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Publication number: 20130039887Abstract: Disclosed herein are methods for identifying compounds for the treatment of viral infection, including RNA viral infection and uses of the compounds as pharmaceutical compositions. The identified compounds modulate the RIG-I pathway in vertebrate cells.Type: ApplicationFiled: April 20, 2011Publication date: February 14, 2013Applicant: KINETA, INC.Inventors: Shawn P. Iadonato, Kristin Bedard, Michael Gale
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Patent number: 7989572Abstract: UV-absorbing polymers and copolymers suitable for Composition into sunscreens for the protection of human skin. The UV-absorbing chromophoric monomers chosen are simple and easily synthesized. With the correct choice of chromophoric monomer or mixture of monomers, protection against UV-A radiation or against both UV-A and UV-B radiation can be achieved. With the correct choice of comonomer, copolymers produced as aqueous latex emulsions or as Polyethylene Glycol solutions can also be achieved.Type: GrantFiled: January 17, 2008Date of Patent: August 2, 2011Assignee: Eastman Chemical CompanyInventors: Robert Joseph Maleski, Ramesh Chand Munjal, Max Allen Weaver, Jean Carroll Fleischer, Michael Gale Ramsey, Greg Alan King, Edward Enns McEntire
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Publication number: 20090248485Abstract: A method of analyzing the effectiveness of marketing activities involves taking a series of surveys that incorporate such factors as the purchase process cycle stages, organization size, respondent job responsibilities, the products offered, and brands involved. The data from the marketing surveys is compiled. A user enters a specific query directed at the data, and the method of the invention is used to present graph of the data results to the user, the graph having a vertical and two horizontal axes. Marketing vehicles are listed on the vertical axis of the graph. On one horizontal axis, a percentage impact awareness score is provided for each marketing vehicle for the selected query, as well as an overall average percentage impact awareness score for all of the marketing vehicles. The other, opposing horizontal axis displays a brand propensity index for each marketing vehicle, as well as an overall average brand propensity index.Type: ApplicationFiled: March 28, 2008Publication date: October 1, 2009Inventors: George Minow, Michael Gale
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Publication number: 20090185988Abstract: UV-absorbing polymers and copolymers suitable for Composition into sunscreens for the protection of human skin. The UV-absorbing chromophoric monomers chosen are simple and easily synthesized. With the correct choice of chromophoric monomer or mixture of monomers, protection against UV-A radiation or against both UV-A and UV-B radiation can be achieved. With the correct choice of comonomer, copolymers produced as aqueous latex emulsions or as Polyethylene Glycol solutions can also be achieved.Type: ApplicationFiled: January 17, 2008Publication date: July 23, 2009Applicant: Eastman Chemical CompanyInventors: Robert Joseph Maleski, Ramesh Chand Munjal, Max Allen Weaver, Jean Carroll Fleischer, Michael Gale Ramsey, Greg Alan King, Edward Enns McEntire
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Patent number: 7223787Abstract: Permissiveness of human cells to replication of susceptible pathogenic human viruses is reduced by treating the cells with a selective inhibitor of prenylation of a host cell protein. Target viruses, especially Flaviviridae, are predetermined to lack a CXXX box and prenylated viral protein, and to be replication-dependent on host protein prenylation. The general method comprises (a) contacting human cells subject to infection by the virus with an effective amount of a selective inhibitor of a prenylation enzyme of the cells; and (b) confirming a resultant reduction in permissiveness of the cells to replication of the virus. Targeted enzymes include prenyl biosynthetic enzyme like HMG CoA reductase farnesyl and/or geranylgeranyl transferase enzymes.Type: GrantFiled: October 21, 2003Date of Patent: May 29, 2007Assignee: Board of Regents, The University of Texas SystemInventors: Michael S. Brown, Jin Ye, Chunfu Wang, Rhea Sumpter, Jr., Joseph L. Goldstein, Michael Gale, Jr.
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Publication number: 20060252119Abstract: Agents that modulate an interaction of an FBL2 protein with an NS5A or NS5B Flaviviridae protein in a mixture are identified by contacting the mixture with a candidate agent under conditions wherein but for the presence of the agent, the FBL2 protein and the Flaviviridae protein engage in a reference interaction; and detecting an agent-biased interaction. Flaviviridae replication is inhibited by contacting a Flaviviridae-infected cell with an FBL2-specific reagent; and detecting a resultant Flaviviridae replication inhibition.Type: ApplicationFiled: May 4, 2005Publication date: November 9, 2006Inventors: Michael Gale, Michael Brown, Joseph Goldstein, Chunfu Wang, Jin Ye
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Patent number: 7067239Abstract: A method for fabricating optical MEMS (optical Micro-Electro-Mechanical Systems or Micro-Opto-Electro-Mechanical Systems (MOEMS)) is described. The basic process involves deposition and patterning of a sacrificial spacer layer and a combined molding and photolithography step. The method described allows the fabrication of micromechanical elements incorporating micro-optical structures such as lenses (diffractive or refractive), gratings (for polarizers or resonant filters), waveguides or other micro-optical relief structures fabricated by UV-curing replication processes.Type: GrantFiled: June 13, 2003Date of Patent: June 27, 2006Assignee: CSEM Centre Suisse d'Electronique et de Microtechnique S.A.Inventors: Samuel Obi, Michael Gale
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Publication number: 20050085529Abstract: Permissiveness of human cells to replication of susceptible pathogenic human viruses is reduced by treating the cells with a selective inhibitor of prenylation of a host cell protein. Target viruses, especially Flaviviridae, are predetermined to lack a CXXX box and prenylated viral protein, and to be replication-dependent on host protein prenylation. The general method comprises (a) contacting human cells subject to infection by the virus with an effective amount of a selective inhibitor of a prenylation enzyme of the cells; and (b) confirming a resultant reduction in permissiveness of the cells to replication of the virus. Targeted enzymes include prenyl biosynthetic enzyme like HMG CoA reductase farnesyl and/or geranylgeranyl transferase enzymes.Type: ApplicationFiled: October 21, 2003Publication date: April 21, 2005Inventors: Michael Brown, Jin Ye, Chunfu Wang, Rhea Sumpter, Joseph Goldstein, Michael Gale
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Publication number: 20040055151Abstract: A method for fabricating optical MEMS (optical Micro-Electro-Mechanical Systems or Micro-Opto-Electro-Mechanical Systems (MOEMS)) is described. The basic process involves deposition and patterning of a sacrificial spacer layer and a combined moulding and photolithography step.Type: ApplicationFiled: June 13, 2003Publication date: March 25, 2004Inventors: Samuel Obi, Michael Gale
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Publication number: 20040032667Abstract: A surface microstructure is superimposed on the surface of a replication mould such as an injection moulding tool insert by laser interference exposure of a mask pattern and etching or electroplating the additional microstructure. The technique enables the post-processing of planar and non-planar replication moulds with additional microstructure to improve the functionality and value of the moulded components. A major area of application is an anti-reflection surface for injection moulded polymer optical components, achieved by the superposition of submicrometer anti-reflection grating structure onto injection moulding tool inserts.Type: ApplicationFiled: August 18, 2003Publication date: February 19, 2004Inventors: Michael Gale, Juergen Sochtig, Markus Rossi
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Publication number: 20020191286Abstract: A method of mass producing polarizes comprises designing by rigorous diffraction theory an optimized grating profile, replicating the profile in a polymer or other substrate, and slope evaporating a metal onto the substrate. The angle of slope evaporation, the metal, and the thickness of the metal are optimized for a given wavelength using rigorous diffraction theory.Type: ApplicationFiled: March 11, 2002Publication date: December 19, 2002Inventors: Michael Gale, Jurgen Soechtig, Christian Zschokke, Marc Schnieper
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Patent number: 6303885Abstract: A bi-stable micro-machined electromechanical system (“MEMS”) switch. In a preferred embodiment, the bi-stable MEMS switch is used in an N×N optical signal switching system. Spring arms act in conjunction with a hollow beam portion of a movable center body of the switch to accommodate strain in the arms as the switch is moved from a first position to a second position, thus avoiding buckling of the spring arms. Both the first and second switch position occur at local minimums of mechanical potential energy, thus providing two stable switch states. The center body is moved in relation to static portions of the switch by an actuator, such as an electro-static comb drive.Type: GrantFiled: March 3, 2000Date of Patent: October 16, 2001Assignee: Optical Coating Laboratory, Inc.Inventors: Bryant P. Hichwa, Cornel Marxer, Michael Gale
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Patent number: 5717349Abstract: A digital peak detector formed of a plurality of comparators for outputting signals which, in combination, can form a thermometer code signal, apparatus for distributing an analog input signal to an input of each of the comparators, a plurality of digital to analog converters (DACs), apparatus for providing an output signal of each DAC to another input of a corresponding comparator, and apparatus for applying a digital signal to an input of each DAC to establish a comparison level against which a corresponding DAC can determine an output signal level.Type: GrantFiled: October 19, 1995Date of Patent: February 10, 1998Assignee: Omega Telemus Inc.Inventors: Pier L. Bortot, P. Michael Gale