Patents by Inventor Michael Galella

Michael Galella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZOLOPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS
    Publication number: 20090093516
    Abstract: Novel compounds are provided which are 11 -beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein G, Q, X, Y, R3, R3a, and R3b are defined herein.
    Type: Application
    Filed: September 9, 2008
    Publication date: April 9, 2009
    Inventors: Jun Li, Jeffrey A. Robl, James J. Li, Lawrence J. Kennedy, Haixia Wang, Jie Jack Li, Xinhua Qian, Rajendra P. Deshpande, Laxma R. Kolla, Reginald O. Cann, Chenkou Wei, Michael Galella
  • Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
    Patent number: 7491725
    Abstract: The invention relates to processes for preparing compounds having the formula, and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R2, R3, R4, and R5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: February 17, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jean Lajeunesse, John D. DiMarco, Michael Galella, Ramakrishnan Chidambaram
  • Polymorphs of an epothilone analog
    Patent number: 7153879
    Abstract: There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: December 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John D. DiMarco, Jack Z. Gougoutas, Imre M. Vitez, Martha Davidovich, Michael A. Galella, Timothy M. Malloy, Zhenrong Guo, Denis Favreau
  • Pyridyl-substituted spiro-hydantoin crystalline forms and process
    Publication number: 20060142319
    Abstract: The invention provides crystalline forms of 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]nicotinic acid, its pharmaceutically acceptable salts, or solvates, thereof Further, a process is provided for preparing substituted spiro-hydantoin compounds of the formula I wherein Z is N or CR4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A1, A2, G, and Q are linkers; and R2, R4a, R4c, and R16 are defined in the specification. The process includes the reaction of N-substituted glycine compound and methylene precursor compound with an alkene compound. The substituted spiro-hydantoin compounds of formulae I and II are useful in the treatment of immune and/or inflammatory diseases.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 29, 2006
    Inventors: Bang-Chi Chen, Albert Delmonte, T.G. Dhar, Michael Galella, Margaret Gleeson, Jack Gougoutas, Douglas McLeod, Huiping Zhang
  • Polymorphs of an epothilone analog
    Publication number: 20060063815
    Abstract: There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.
    Type: Application
    Filed: November 10, 2005
    Publication date: March 23, 2006
    Inventors: John DiMarco, Jack Gougoutas, Imre Vitez, Martha Davidovich, Michael Galella, Timothy Malloy, Zhenrong Guo, Denis Favreau
  • Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
    Publication number: 20060004067
    Abstract: The invention relates to processes for preparing compounds having the formula, and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R2, R3, R4, and R5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.
    Type: Application
    Filed: July 29, 2005
    Publication date: January 5, 2006
    Inventors: Bang-Chi Chen, Roberto Droghini, Jean Lajeunesse, John DiMarco, Michael Galella, Ramakrishnan Chidambaram
  • Polymorphs of an epothilone analog
    Patent number: 6982276
    Abstract: There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: January 3, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John D. DiMarco, Jack Z. Gougoutas, Imre M. Vitez, Martha Davidovich, Michael A. Galella, Timothy M. Malloy, Zhenrong Guo, Denis Favreau
  • Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
    Publication number: 20050215795
    Abstract: The invention relates to processes for preparing compounds having the formula, and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R2, R3, R4, and R5, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.
    Type: Application
    Filed: February 4, 2005
    Publication date: September 29, 2005
    Inventors: Bang-Chi Chen, Roberto Droghini, Jean Lajeunesse, John Dimarco, Michael Galella, Ramakrishnan Chidambaram
  • Polymorphs of an epothilone analog
    Publication number: 20040157897
    Abstract: There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula 1
    Type: Application
    Filed: February 6, 2004
    Publication date: August 12, 2004
    Inventors: John D. DiMarco, Jack Z. Gougoutas, Imre M. Vitez, Martha Davidovich, Michael A. Galella, Timothy M. Malloy, Zhenrong Guo, Denis Favreau
  • Polymorphs of an epothilone analog
    Patent number: 6689802
    Abstract: There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: February 10, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: John D. DiMarco, Jack Z. Gougoutas, Imre M. Vitez, Martha Davidovich, Michael A. Galella, Timothy M. Malloy, Zhenrong Guo, Denis Favreau
  • Polymorphs of an epothilone analog
    Publication number: 20020188014
    Abstract: There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula 1
    Type: Application
    Filed: August 9, 2001
    Publication date: December 12, 2002
    Inventors: John D. DiMarco, Jack Z. Gougoutas, Imre M. Vitez, Martha Davidovich, Michael A. Galella, Timothy M. Malloy, Zhenrong Guo, Denis Favreau