Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The present disclosure relates to systems, methods and compositions provided herein that include a compound protease. The compound protease can contain a protease domain, a cut site for another enzyme and an association domain. In some embodiments, the compound protease is part of a protein circuit.

Abstract: Disclosed are polymeric foamed compositions, foam padded materials that include such polymeric foamed compositions disposed on a sheet material, and packaging articles (e.g., envelopes) made from such foam padded materials. The polymeric foamed composition on the sheet material has a plurality of foamed structures formed from the foamable composition attached to the sheet material by a layer of the foamable composition, and the plurality foam structures each having a hollow core and a foam exterior shell.

Abstract: Gas bubble migration can be managed in liquids. In one example, a system can execute wellbore-simulation software to simulate changes in gas dissolution in a liquid over time. This may involve dividing the wellbore into segments spanning from the well surface to the downhole location, each segment spanning a respective depth increment between the well surface and the downhole location. Next, for each time, the system can determine a respective multiphase-flow regime associated with each segment of the plurality of segments based on a simulated pressure level, a simulated temperature, a simulated pipe eccentricity, and a simulated fluid velocity at the segment. The system can also determine how much of the gas is dissolved in the liquid at each segment based on the respective multiphase-flow regime at the segment. The system can display a graphical user interface representing the gas dissolution in the liquid over time.

Abstract: A depth camera assembly (DCA) determines depth information for a local area. The DCA includes a camera assembly and at least one illuminator. The DCA may select a subset of the VCSELs to provide illumination at any given time. The illuminator may comprise near-field VCSELs configured to generate a structured light (SL) pattern for depth sensing in the near-field and far-field VCSELs configured to generate a SL pattern for depth sensing in the far-field. The near-field VCSELs may comprise a linear emission region which is shorter than a linear emission region of the far-field VCSELs. The DCA may generate and phase shift a quasi-sinusoidal SL pattern. The DCA may phase shift the quasi-sinusoidal SL pattern by alternating which traces on the illuminator are active.

Abstract: Disclosed herein include methods, compositions, and systems suitable for use in delivering a polynucleotide to a target cell of a subject in need thereof. In some embodiments, a viral vector comprises a polynucleotide encoding nucleoprotein (N), phosphoprotein (P), matrix protein (M), RNA-dependent RNA polymerase (L), and one or more transgenes. The viral vector can comprise one or more of a conditionally stable fusion protein, a protease fusion protein, a degron fusion protein, and/or a glycoprotein derived of another species than the viral vector polynucleotide to enable control of viral vector transduction and/or replication.

Abstract: An electronic device has a keyboard with an internal membrane. The membrane has a set of strain gauges configured to respond to a key press, such as when a collapsible dome collapses into contact with the membrane. The strain gauges are connected in a half Wheatstone bridge configuration and are positioned on the membrane in order to limit effects of temperature and subtle flexure of the membrane. The strain gauges are also configured to magnify detection of a resistance differential when a keycap is pressed with sufficient force.

Abstract: An image-reading device, such as optical code readers used in retail environments to scan objects, is configured to select from various operational modes. The operational modes are selected based on an application of the image-reading device, such as optical code identification or image recognition. Red, white, and other color light sources are activated in patterns corresponding to an illumination sequence of the selected operational mode, while imagers are activated to capture an image based on an exposure pattern of the selected operational mode. Further, a repeating series of light pulses having different portions of light is provided. Various imagers are configured to capture images over one of the portions. This allows an operator to perceive one continuous light pattern, yet allows various imagers to capture an image under different light conditions used for different applications of the image-reading device.

Abstract: A method for assessing an effect, such as a treatment, disease, or passage of time on a cellular unit of an organism includes providing a sample including a cellular unit subject to the effect in a supporting medium in a hermetically sealed container. The container is deoxygenated to induce at least one of a predetermined amount of hypoxia and a predetermined rate of oxygen consumption in the medium. Values for variables associated with the medium and/or the cellular unit are determined at each of a plurality of different times. Various combinations of the predetermined amount of hypoxia, the predetermined rate of oxygen consumption, the values for the variables associated with the medium and/or cellular unit, and the times and then correlated to generate a multi-dimensional surface. This surface is compared with another surface correlating corresponding values relating to another cellular unit such as one not subject to the effect.

Abstract: An optical link system for computation, preferably including a photonics substrate and a plurality of electronics modules, such as processors, memory controllers, and/or switches, which are preferably bonded to the photonics substrate. A photonics substrate, preferably including a plurality of optical links including waveguides and optical transducers. A method for optical link system operation, preferably including operating electronics modules and using optical links, optionally in cooperation with electronics modules such as switches, to transfer information between the electronics modules.

Abstract: A battery electrode for an electrochemical cell that cycles lithium ions is described and includes: a first separator layer including a first side and a second side; a first conductive porous layer located on the first side of the first separator layer; and an active material layer to cycle lithium ions and including a first side and a second side, where the first side of the active material layer is in contact with the first conductive porous layer.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: Users of personalized messaging systems can encounter message fatigue, thereby reducing the efficacy of a message on its intended recipient. Message fatigue can result in wasted computational resources and bandwidth as messages transmitted over a network to the user's client device are not acted upon at the client device. For applications involving desired user interactions and responses, personalized messaging can be a tool to achieve user engagement targets. The systems and methods presented herein may address several of the technical challenges with personalized messaging.

Abstract: A photonic computing system, preferably including an input module, a computation module, and/or control module. The photonic computing system can include one or more optical filter banks, such as in the computation module and/or any other suitable modules. Each optical filter bank preferably includes a plurality of photonic bandgap phase modulators. Each photonic bandgap phase modulator preferably includes a set of photonic crystal segments. The photonic crystal segments can preferably be controlled to transition light propagation between two or more photonic bands.

Abstract: A photonic computing system, preferably including an input module, a computation module, and/or control module. The photonic computing system can include one or more optical filter banks, such as in the computation module and/or any other suitable modules. Each optical filter bank preferably includes a plurality of photonic bandgap phase modulators. Each photonic bandgap phase modulator preferably includes a set of photonic crystal segments. The photonic crystal segments can preferably be controlled to transition light propagation between two or more photonic bands.

Abstract: An optical link system for computation, preferably including a photonics substrate and a plurality of electronics modules, such as processors, memory controllers, and/or switches, which are preferably bonded to the photonics substrate. A photonics substrate, preferably including a plurality of optical links including waveguides and optical transducers. A method for optical link system operation, preferably including operating electronics modules and using optical links, optionally in cooperation with electronics modules such as switches, to transfer information between the electronics modules.

Abstract: A system for parallel photonic computation, preferably including a source module, a plurality of input modulator units, an optical interference unit (OIU), and a plurality of detector banks. An OIU, preferably including one or more unitary matrix modules and optionally including a diagonal matrix module. An input modulator, which can include one or more waveguides, couplers, and/or modulator banks. A method for parallel photonic computing, preferably including encoding input vectors, performing a desired matrix operation, and receiving output values, and optionally including performing electronic computations and/or performing further optical computations based on the outputs, which can function to compute the results of a matrix operation on many different input vectors in parallel.

Abstract: An optical link system for computation, preferably including a photonics substrate and a plurality of electronics modules, such as processors, memory controllers, and/or switches, which are preferably bonded to the photonics substrate. A photonics substrate, preferably including a plurality of optical links including waveguides and optical transducers. A method for optical link system operation, preferably including operating electronics modules and using optical links, optionally in cooperation with electronics modules such as switches, to transfer information between the electronics modules.

Abstract: A digital-to-analog converter (DAC) system preferably includes one or more optical modulators and can optionally include one or more electronic DAC arrays. A method for digital-to analog conversion preferably includes receiving digital inputs and providing analog optical outputs. The method for digital-to analog conversion is preferably performed using the DAC system.

Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject.