Patents by Inventor Michael Garret Roepel

Michael Garret Roepel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 8-aza-11-deoxy prostaglandin analogues
    Patent number: 6900336
    Abstract: This invention relates to compounds which are generally EP4 receptor agonists and which are represented by Formula I: wherein A is a —CH2—CH2—, or —CH?CH—; B is absent, an aryl, or heteroaryl group; R1 is alkyl, alkenyl, alkynyl, cycloalkylalkyl, heterocyclylalkyl, aryl, arylalkyl or heteroaryl, when B is aryl or heteroaryl and R3, R4, R5 and R6 are not simultaneously hydrogen, or R1 is heterocyclylalkyl, aryl, or heteroaryl when B is absent and R3, R4, R5 and R6 are simultaneously hydrogen; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: May 31, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Todd Richard Elworthy, Tara Mirzadegan, Michael Garret Roepel, David Bernard Smith, Keith Adrian Walker
  • 2-pyrrolidone derivatives as prostanoid agonists
    Patent number: 6849657
    Abstract: This invention relates to 8-aza prostanoid analogs which are generally EP4 receptor agonists and are represented by Formula I: wherein Q, B, X, J, Z, A and R1-R6 are as defined, their synthesis and use for treatment of osteoporosis and increasing bone density.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: February 1, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Todd Richard Elworthy, Michael Garret Roepel, David Bernard Smith
  • 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists
    Publication number: 20030199532
    Abstract: This invention relates to certain 2,4-substituted pyrrolidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Application
    Filed: February 18, 2003
    Publication date: October 23, 2003
    Inventors: Denis John Kertesz, Michael Garret Roepel
  • 8-Aza-11-deoxy prostaglandin analogues
    Publication number: 20030120079
    Abstract: This invention relates to compounds which are generally EP4 receptor agonists and which are represented by Formula I: 1
    Type: Application
    Filed: July 16, 2002
    Publication date: June 26, 2003
    Inventors: Todd Richard Elworthy, Tara Mirzadegan, Michael Garret Roepel, David Bernard Smith, Keith Adrian Walker
  • 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists
    Patent number: 6552028
    Abstract: This invention relates to certain 2,4-substituted pyrrolidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: April 22, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Denis John Kertesz, Michael Garret Roepel
  • 2-pyrrolidone derivatives as prostanoid agonists
    Publication number: 20030064964
    Abstract: This invention relates to 8-aza prostanoid analogs which are generally EP4 receptor agonists and are represented by Formula I: 1
    Type: Application
    Filed: July 16, 2002
    Publication date: April 3, 2003
    Inventors: Todd Richard Elworthy, Michael Garret Roepel, David Bernard Smith
  • 2,4-substituted pyrrolidine derivatives-CCR-3 receptor antagonists
    Publication number: 20020198255
    Abstract: This invention relates to certain 2,4-substituted pyrrolidine derivatives that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Application
    Filed: December 19, 2001
    Publication date: December 26, 2002
    Inventors: Denis John Kertesz, Michael Garret Roepel