Patents by Inventor Michael GARTON

Michael GARTON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN-SILICO METHOD FOR DESIGNING A (D)-POLYPEPTIDE LIGAND
    Publication number: 20210057047
    Abstract: A method for designing in-silico a (D)-polypeptide ligand that binds with a target is provided. The method includes providing a (L)-polypeptide ligand that binds with the target, the (L)-polypeptide ligand comprising one or more (L)-helical region; for each of the one or more (L)-helical region: identifying hotspot residues of the one or more (L)-helical region, that interact with residues of the target; and scanning a (D)-polypeptide database comprising single helix (D)-polypeptide candidates, to determine a single helix (D)-polypeptide match having a residue configuration that matches the hotspot residues of the one or more (L)-helical region; and generating the (D)-polypeptide ligand by combining the single helix (D)-polypeptide match of each of the one or more (L)-helical region.
    Type: Application
    Filed: January 8, 2019
    Publication date: February 25, 2021
    Inventors: Michael GARTON, Satra NIM, Philip M. KIM