Patents by Inventor Michael Gassen
Michael Gassen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8227516Abstract: The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.Type: GrantFiled: July 16, 2007Date of Patent: July 24, 2012Assignee: 4SC Discovery GmbHInventors: Alexander B. Maurer, Sascha Hoevelmann, Elke Martin, Bernd Hentsch, Michael Gassen, Juergen Kraus, Rolf Krauss, Adam-Spencer Vincek
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Publication number: 20090088478Abstract: The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.Type: ApplicationFiled: July 16, 2007Publication date: April 2, 2009Inventors: Alexander B. Maurer, Sascha Hoevelmann, Elke Martin, Bernd Hentsch, Michael Gassen, Juergen Kraus, Rolf Krauss, Adam-Spencer Vincek
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Patent number: 7491742Abstract: Imidazole derivatives of the formula I in which R1 is H, A, benzyl, indan-5-yl, 1,2,3,4-tetrahydronaphthalen-5-yl, dibenzothien-2-yl, or phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, A-CO—NH, benzyloxy, alkoxy, COOH or COOA, R2 is H or A, X is O or S, Hal is F, Cl, Br or I, A is alkyl with 1 to 6 C atoms, and the physiologically acceptable salts and/or solvates thereof as phosphodiesterase VII inhibitors and the use thereof for producing a pharmaceutical.Type: GrantFiled: January 5, 2004Date of Patent: February 17, 2009Assignee: Merck Patent GmbHInventors: Hans-Michael Eggenweiler, Rochus Jonas, Michael Wolf, Michael Gassen, Oliver Pöschke
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Patent number: 7485639Abstract: Triazine derivatives of the formula (I) and physiologically acceptable salts and solvates thereof, in which R1, R2, A and R5 are as defined in Claim 1, exhibit phosphodiesterase IV inhibition and can be employed for the treatment of allergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, autoimmune diseases, such as, for example, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumour growth or tumour metastases, sepsis, memory disorders, atherosclerosis and AIDS, furthermore for inhibiting the formation of TNF?.Type: GrantFiled: June 19, 2002Date of Patent: February 3, 2009Assignee: Merck Patent GmbHInventors: Hans-Michael Eggenweiler, Michael Wolf, Norbert Beier, Joachim Leibrock, Pierre Schelling, Michael Gassen, Thomas Ehring
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Patent number: 7312328Abstract: This invention relates to compounds of the formula (I) in which R1, R2, R3, X and Q are as defined above and their use as PDE IV inhibitors.Type: GrantFiled: December 19, 2001Date of Patent: December 25, 2007Assignee: Merck Patent GmbHInventors: Hans-Michael Eggenweiler, Michael Wolf, Norbert Beier, Joachim Leibrock, Michael Gassen, Thomas Ehring
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Patent number: 7250279Abstract: hPDP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hPDP polypeptides and polynucleotides in diagnostic assays.Type: GrantFiled: April 6, 2001Date of Patent: July 31, 2007Assignee: Merck Patent GmbHInventors: Izaak Den Daas, Michael Gassen, Joachim Leibrock, Laurie Von Melchner
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Patent number: 7087716Abstract: RGS8 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing RGS8 polypeptides and polynucleotides in diagnostic assays.Type: GrantFiled: May 10, 2001Date of Patent: August 8, 2006Assignee: Merck Patent GmbHInventors: Claudia Wilm, Michael Gassen
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Publication number: 20050176686Abstract: The present invention is directed to compounds of the general formula (I) or pharmaceutical acceptable salts or physiologically functional derivatives thereof wherein: n is a non-aromatic ring system containing two to seven carbon atoms, wherein the ring system can contain one ore two double bonds; X is C, CH or CH2; Y is selected from C, CH, CH2, S, NR, CH2-CH2, H2C—CH, HC—CH2, C—CH2, H2C—C, or C—C; one or more of the hydrogen atoms can optionally be substituted by one or more substituents R?; each of the dotted lines means a single, a double or triple bond with the exclusion of a combination of a triple with triple bond and a double with a triple bond; R? is independently H, —CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogene, haloalkyl, haloalkyloxy; R is H, an alkyl or cycloalkyl group; Z is CH, C, or P; p is 0 or 1.Type: ApplicationFiled: July 23, 2003Publication date: August 11, 2005Applicants: 4SC AG, G2M Cancer Drugs AGInventors: Alexander Maurer, Sascha Hoevelmann, Elke Martin, Bernd Hentsch, Michael Gassen, Juergen Kraus, Rolf Krauss, Adam-Spencer Vincek
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Patent number: 6884800Abstract: Imidazole compounds of the formula I in which R1 and R2, independently of one another, each denote A1, OA1, SA1 or Hal, A1 denotes H, A, alkenyl, cycloalkyl or alkylenecycloalkyl, A denotes alkyl having 1-10 carbon atoms, Hal denotes F, Cl, Br or I, and X denotes O, S, SO or SO2, and their physiologically acceptable salts and/or solvates, as phosphodiesterase VII inhibitors, and their use for the preparation of a medicament.Type: GrantFiled: October 31, 2000Date of Patent: April 26, 2005Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Hans-Michael Eggenweiler, Rochus Jonas, Michael Wolf, Michael Gassen, Thomas Welge
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Publication number: 20050070529Abstract: The invention relates to the use of type 4 phosphodiesterase inhibitors to treat myocardial diseases.Type: ApplicationFiled: January 15, 2002Publication date: March 31, 2005Applicant: Merk Pantent GmbHInventors: Arne Sutter, Thomas Ehring, Thomas Welge, Klause Minck, Claudia Wilm, Michael Gassen, Hans-Michael Eggenweiler, Michael Wolf, Pierre Schelling, Norbert Beier, Joachim Leibrock
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Publication number: 20040176252Abstract: Triazine derivatives of the formula (I) and physiologically acceptable salts and solvates thereof, in which R1, R2, A and R5 are as defined in claim 1, exhibit phosphodiesterase IV inhibition and can be employed for the treatment of allergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, autoimmune diseases, such as, for example, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumour growth or tumour metastases, sepsis, memory disorders, atherosclerosis and AIDS, furthermore for inhibiting the formation of TNF&agr;.Type: ApplicationFiled: January 20, 2004Publication date: September 9, 2004Inventors: Hans-Michael Eggenweiler, Michael Wolf, Norbert Beier, Joachim Leibrock, Pierre Schelling, Michael Gassen, Thomas Ehring
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Publication number: 20040138279Abstract: Imidazole derivatives of the formula I 1Type: ApplicationFiled: January 5, 2004Publication date: July 15, 2004Inventors: Hans-Michael Eggenweiler, Rochus Jonas, Michael Wolf, Michael Gassen, Oliver Poschke
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Patent number: 6737426Abstract: The invention relates to compounds of the general formula (I) where R1 and R2 independently of one another are H, —R6, C3-C8-cycloalkyl, —(CH2)n—R7, —(CH2)n—O—R6, —(CH2)n—NH2, —(CH2)n—NHR6, —(CH2)—N(R6)2, C2-C6-alkenyl or, where appropriate, together form a mononuclear saturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms, R3 and R4 independently of one another are H, —R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2, R5 is a 5- or 6-membered, saturated or unsaturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms which may be mono- or disubstituted by R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2, and R6 is C1-C6-alkyl, R7 is R3- and/or R4-substituted phenyl, n is 0 to 2, and physiologically acceptable salts or solvates thereoType: GrantFiled: May 28, 2002Date of Patent: May 18, 2004Assignee: Merck Patent GmbHInventors: Rolf Gericke, Henning Böttcher, Michael Gassen, Hartmut Greiner
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Patent number: 6737436Abstract: Compounds of the formula I in which R1 and R2, independently of one another, each denote H, A, OA, SA or HaI, R3 denotes H or A, R4 denotes A or NH2, R5 denotes H, NH2, NHA or NA2, A denotes alkyl having 1 to 10 carbon atoms, alkenyl, cycloalkyl or alkylenecycloalkyl, Hal denotes F, Cl, Br or I, and their physiologically acceptable salts and/or solvates, as phosphodiesterase VII inhibitors.Type: GrantFiled: May 3, 2002Date of Patent: May 18, 2004Assignee: Merck Patent GmbHInventors: Hans-Michael Eggenweiler, Rochus Jonas, Michael Wolf, Michael Gassen, Thomas Welge
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Publication number: 20040067954Abstract: This invention relates to compounds of the formula (I) in which R1, R2, R3, X and Q are as defined above and their use as PDE IV inhibitors.Type: ApplicationFiled: June 23, 2003Publication date: April 8, 2004Inventors: Hans-Michael Eggenweiler, Michael Wolf, Norbert Beier, Joachim Leibrock, Michael Gassen, Thomas Ehring
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Publication number: 20030186264Abstract: hPDP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hPDP polypeptides and polynucleotides in diagnostic assays.Type: ApplicationFiled: October 4, 2002Publication date: October 2, 2003Inventors: Izaakden Daas, Michael Gassen, Joachim Leibrock, Laurie von Melchner
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Patent number: 6613778Abstract: Compounds of the formula I in which R1 denotes CONR4R5, R2 denotes H or A, R4 and R5, independently of one another, each denote H or A1, R3 denotes Hal, Hal denotes F, Cl, Br or I, A denotes alkyl having 1-4 carbon atoms, A1 denotes alkyl having 1-10 carbon atoms, X denotes alkylene having 1-4 carbon atoms, in which an ethylene group may also be replaced by a double or triple bond, and their physiologically acceptable salts and/or solvates, as phosphodiesterase VII inhibitors, and their use for the preparation of a medicament.Type: GrantFiled: May 3, 2002Date of Patent: September 2, 2003Assignee: Merck Patent Gesellschaft mit beschränkter HaftungInventors: Hanse-Michael Eggenweiler, Karl-August Ackermann, Rochust Jonas, Michael Wolf, Michael Gassen, Thomas Welge
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Publication number: 20030104450Abstract: RGS8 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing RGS8 polypeptides and polynucleotides in diagnostic assays.Type: ApplicationFiled: November 7, 2002Publication date: June 5, 2003Inventors: Claudia Wilm, Michael Gassen
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Patent number: 6531498Abstract: The invention relates to compounds of formula I and to their physiologically acceptable salts and solvates which act as phosphodiesterse VII inhibitors and are thus useful for the treatment of allergic disorders, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin disorders, inflammatory disorders, autoimmune diseases, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumor growth, tumor metastases, sepsis, memory disturbances, atherosclerosis and AIDS.Type: GrantFiled: May 3, 2002Date of Patent: March 11, 2003Assignee: Merck PatentgesellschaftInventors: Hans-Michael Eggenweiler, Rochus Jonas, Michael Wolf, Michael Gassen, Thomas Welge