Abstract: An oral appliance and kit therefor is disclosed. The oral appliance may include generally U-shaped upper and lower body members and a pair of adjustment plates or spacers for removably connecting the upper body member with the lower body member. The generally U-shaped upper and lower body members are adapted to be positioned over at least a portion of first and second arches of teeth, respectively, with the spacers having a system of pins or pegs for adjustably repositioning the upper body member with respect to the lower body member. The upper and lower body members are further configured to provide a lingual-less open space between the upper and lower body members to accommodate a tongue in a relaxed state. The disclosed oral appliance, system and kit therefor is configured for use in correcting the misalignment of a user's jaw.

Abstract: Provided are molecules and methods for detecting enzymatic activity of various lysosomal storage enzymes. The molecules may be used as internal standards that may be combined with substrates that have improved solubility.

Abstract: Methods are provided for detecting enzymatic activity of various lysosomal storage enzymes using substrates that include: a sugar moiety; a linker moiety allowing the conjugation of sugar moiety with the remaining structure of the substrate; and two or more fatty acid chains or derivatives thereof at least one of which is sufficiently structured to provide improved solubility in aqueous or organic solvent systems. Also provided are internal standards, and inhibitors for use in detecting or reducing enzymatic activity using the inventive substrates.

Abstract: The present invention provides a method and apparatus for non-surgical treatment of the lower face and lips to achieve an aesthetic appearance and anatomical alignment of a patients jaw and associated skeletal features to achieve an orthognathic facial profile, with approved appearance and enabling future treatments without direct surgical impact. The invention relates to the oral apparatus being an appliance having a specified structure thereon.

Abstract: An oral appliance and kit therefor is disclosed. The oral appliance may include generally U-shaped upper and lower body members and a pair of adjustment plates or spacers for removably connecting the upper body member with the lower body member. The generally U-shaped upper and lower body members are adapted to be positioned over at least a portion of first and second arches of teeth, respectively, with the spacers having a system of pins or pegs for adjustably repositioning the upper body member with respect to the lower body member. The upper and lower body members are further configured to provide a lingual-less open space between the upper and lower body members to accommodate a tongue in a relaxed state. The disclosed oral appliance, system and kit therefor is configured for use in correcting the misalignment of a user's jaw.

Abstract: Methods are provided for detecting enzymatic activity of various lysosomal storage enzymes using substrates that include: a sugar moiety; a linker moiety allowing the conjugation of sugar moiety with the remaining structure of the substrate; and two or more fatty acid chains or derivatives thereof at least one of which is sufficiently structured to provide improved solubility in aqueous or organic solvent systems. Also provided are internal standards, and inhibitors for use in detecting or reducing enzymatic activity using the inventive substrates.

Abstract: Substrates are provided that include compounds suitable for detecting the activity of an enzyme such as a lysosomal storage enzyme where the substrates include: a sugar moiety; a linker moiety allowing the conjugation of sugar moiety with the remaining structure of the substrate; and two or more fatty acid chains or derivatives thereof at least one of which is sufficiently structured to provide improved solubility in aqueous or organic solvent systems. Also provided are methods for using substrates for detecting enzymatic activity using the inventive substrates.

Abstract: Oral appliances which reside within the mouth and which bring the lower jaw and/or the tongue forward to increase airway flow during sleep or physical activity are provided. Furthermore, the oral appliances are constructed such that they may be optionally customized to an individual user's mouth shape. Methods of using such oral appliances are also provided.

Abstract: An oral appliance including a flexible sheet having opposite faces and an edge surrounding the faces, a protrusion extending from at least one of the faces of the flexible sheet, and a notch formed in the edge of the flexible sheet.

Abstract: The present invention relates to compounds according to the formula (I): Where RA is a C1-C10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group according to the formula (II): RB is a C1-C10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group of the formula (III): R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are each independently selected from H, C1-C10 (preferably a C1-C4) alkyl or alkenyl group, CF3, F, Cl, Br, I, CN, NO2, NH2, NHR, NRR, COR (acyl group), OR (hydroxyl or ether group), CO2R (carboxylic acid or ester group), or COSR (thioester group) where R is H or a C1-C10 (preferably a C1-C4) alkyl or alkenyl group, an unsubstituted or substituted aryl (preferably, phenyl) or heterocycle group, or a (IV) group, where R3 is H, a C1-C10 (preferably a C1-C4) alkyl, alkenyl, ether or a thioether group; and R11 and R12 are independently selected from H or a C1-C3 alkyl or alkenyl group, or a pharmaceutically ac

Abstract: Analytical reagents and mass spectrometry-based methods using these reagents for the rapid, and quantitative analysis of proteins or protein function in mixtures of proteins. The methods employ affinity labeled protein reactive reagents having three portions: an affinity label (A) covalently linked to a protein reactive group (PRG) through a linker group (L). The linker may be differentially isotopically labeled, e.g., by substitution of one or more atoms in the linker with a stable isotope thereof. These reagents allow for the selective isolation of peptide fragments or the products of reaction with a given protein (e.g., products of enzymatic reaction) from complex mixtures. The isolated peptide fragments or reaction products are characteristic of the presence of a protein or the presence of a protein function in those mixtures. Isolated peptides or reaction products are characterized by mass spectrometric (MS) techniques.

Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance.

Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance. Also disclosed are novel Farnesyl Protein Transferase inhibitors.

Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance.

Abstract: A sculpture is provided having cuts extending from an exterior surface to an internal position. The cuts are then smoothed using a solvent and simultaneously dyed with an appropriate pigment. The resulting internal faces exhibit both reflectivity and translucency depending on the illumination and viewing angles.