Abstract: A bone implant body serves to be introduced into a bone defect location to promote bone growth in this bone defect location. It has a main body made of a deformable and porous collagen matrix, which contains at least one main body collagen material of a first proportion in the form of a mineralized collagen and a second proportion in the form of a native collagen, and a depot member, which is completely embedded in the main body such that the depot member is completely surrounded by the collagen matrix of the main body and placed centrally within the main body and contains, as a first constituent, at least one depot material in the form of at least one bioactive substance which promotes bone healing. A transition between the collagen matrix of the main body and the depot member is formed by an interfacial area of the depot member.

Abstract: The present invention relates to 3D printable composition comprising a cross-linkable component, a non-cross-linkable polymer, and analyte sensor particles, and to a method of fabricating a scaffold for living cells, a scaffold for a living cell, and a kit of parts comprising components for performing the method to obtain the scaffold. The scaffold is useful for prolonged culture of living cells and allows monitoring a metabolite throughout the culture with high spatial resolution of the metabolite in the scaffold.

Abstract: A scaffold for tissue culture and cell culture and for producing implant materials, in particular bone, cartilage or skin replacements or extra-corporal organ replacements or for other applications in medicine or biotechnology is made of biocompatible materials. It has at least one base material which is electrostatically flocked with fibers on at least one side. Through the electrostatic flocking the fibers are arranged almost perpendicularly on the surface of the base material and exhibits a high fiber pull-out resistance. The scaffold provides an elastic growth lattice, which is stable against compression, for cell colonization in vitro or the ingrowth of cells in vivo. Implants or implant materials can be produced with the scaffold.

Abstract: A calcium phosphate bone cement setting to a calcium-deficient hydroxyl apatite is modified by an organic phosphate ester of orthophosphoric acid or a salt of an organic phosphate ester. The base cement contains preferably tricalcium phosphate, dicalcium phosphate (anhydrous), calcium carbonate and precipitated hydroxyl apatite. The organic phosphate ester is added to the base cement in an amount of 0.5 to 5 percent by weight. The bone cement can be modified further by adding mineralized collagen I.

Abstract: A scaffold for tissue culture and cell culture and for producing implant materials, in particular bone, cartilage or skin replacements or extra-corporal organ replacements or for other applications in medicine or biotechnology is made of biocompatible materials. It has at least one base material which is electrostatically flocked with fibers on at least one side. Through the electrostatic flocking the fibers are arranged almost perpendicularly on the surface of the base material and exhibits a high fiber pull-out resistance. The scaffold provides an elastic growth lattice, which is stable against compression, for cell colonization in vitro or the ingrowth of cells in vivo. Implants or implant materials can be produced with the scaffold.