Patents by Inventor Michael Gene Bramucci

Michael Gene Bramucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial positive selection vector
    Patent number: 6048694
    Abstract: A positive selection vector is provided for the transformation and screening of Gram positive bacteria and particularly Bacillus sp. for the presence of foreign DNA. The vector comprises a mutant gene encoding a signal peptide processing mutation. Expression of the mutant gene in a Bacillus host cell which lacks the ability to metabolize sucrose is lethal when cells are grown in the presence of sucrose. Foreign DNA may be inserted into the vector so as to inactivate the mutant gene thereby permitting the cells to grow in the presence of sucrose and allowing for facile selection of transformants.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: April 11, 2000
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Michael Gene Bramucci, Vasantha Nagarajan