Abstract: A single-ply dispersible wet wipe constructed from a single-ply wipe substrate containing a fibrous substrate and a binder composition is disclosed. The binder composition may be applied substantially to the outer surfaces of the fibrous substrate. The wet wipes also contain a wetting composition containing between about 0.5 and about 3.5 percent of an insolubilizing agent, such as salt. Upon agitation in water for ten minutes or less, the single-ply wipe substrate splits into two sections to enhance the dispersibility of the product.