Abstract: Methods disclosed herein concern cancer proteogenomics, which integrates genomics, transcriptomics and mass spectrometry (MS)-based proteomics to gain insights into cancer biology and treatment efficacy. To promote clinical utility of embodiments herein, proteogenomics approaches were developed for frozen core needle biopsies using tissue-sparing specimen processing with or without a microscaled proteomics workflow.

Abstract: The present disclosure provides for compositions and methods of treating cancer. In some embodiments, PTPN11 is targeted with and anti-PTPN11 drug, such as a Shp2 inhibitor (e.g., SHP099). In some embodiments, other upregulated, hyperphosphorylated, or hyperacetylated target proteins are inhibited or targeted.

Abstract: Some embodiments of the present disclosure include a puncturable cover for accessing the contents of a container, wherein the puncturable cover includes a plurality of segments separated by a plurality of score lines. In embodiments, the puncturable cover may be part of a storage device for holding dry goods, wherein the storage device includes a container configured to accommodate a volume of the dry goods, the container having a rim; the puncturable cover; and a lid configured to removably cover the puncturable cover, wherein before the puncturable cover is punctured, the score lines extend partially through a width of the puncturable cover.

Abstract: The invention relates to tuberculosis diagnostic methods and devices that measure particular biomarker profiles in subjects and identify a subject having tuberculosis based on such profiles.

Abstract: A merchandiser including a case defining a product display area and having a base and a frame coupled to the base, and case structure coupled to the frame. The merchandiser also includes a leveler mechanism that is coupled to the case structure and that has a connector rod and a coupler attached adjacent an end of the connector rod. The leveler mechanism has a length defined by the connector rod and the coupler, and the connector rod is rotatable relative to the coupler to rotate to raise or lower the case structure based on the direction of rotation.

Abstract: The invention relates to tuberculosis diagnostic methods and devices that measure particular biomarker profiles in subjects and identify a subject having tuberculosis based on such profiles.

Abstract: An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold—over clinically relevant size scales—sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via ‘contact degradation.’ A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs.

Abstract: A Stringed Musical Instrument A stringed musical instrument having a body includes a soundboard (602, 202) and a bridge (250) directly or indirectly connected to the soundboard via a frame (216, 518, 220, 222, 224) that is at least partially fitted within the body of the instrument.

Abstract: A car seat is formed with a harness storage cavity in the car seat shell for placement of the five-point harness to permit the conversion of the car seat into a belt positioning booster configuration without requiring the harness to be removed from the car seat shell. The headrest and back panel pads on the back rest are removed to provide access to the harness storage cavity which is covered by a hinged door. The harness buckle and the chest clip, still attached to the harness webbing, are placed into the storage cavity and the door closed to provide a flush surface on the seat back so that the child has a smooth supporting surface. The harness webbing projects out of slots to allow the webbing to lie flat beneath the headrest and back panel pads when replaced over the closed door to the storage cavity.

Abstract: An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold—over clinically relevant size scales—sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via ‘contact degradation.’ A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs.

Abstract: A Stringed Musical Instrument A stringed musical instrument having a body includes a soundboard (602, 202) and a bridge (250) directly or indirectly connected to the soundboard via a frame (216, 518, 220, 222, 224) that is at least partially fitted within the body of the instrument.

Abstract: Methods and systems forming biocompatible materials are disclosed herein. Forming a biocompatible material may include contacting a liquid, having a linking material, with an adjoining material having embedded therein a nucleating material that causes the linking material to nucleate and grow into the liquid. After a time sufficient to cause the linking material to grow substantially from the nucleating material into a space occupied by the liquid, the liquid may be solidified to form a solid such that the linking material secures the solid to the adjoining material.