Patents by Inventor Michael Gillette

Michael Gillette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH RISK BIOMARKERS FOR MYELOMA PRECURSOR DISEASE PROGRESSION AND METHODS OF USE THEREOF
    Publication number: 20250189529
    Abstract: Provided herein are biomarkers and combinations of biomarkers for use in manufacturing panels for determining whether a patient is at risk for multiple myeloma precursor disease progression. Also provided herein are methods of treatment for subjects identified as being at risk for multiple myeloma precursor disease progression.
    Type: Application
    Filed: December 6, 2024
    Publication date: June 12, 2025
    Applicants: Dana-Farber Cancer Institute, Inc., The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Elizabeth Lightbody, Irene M. Ghobrial, Steven Carr, Denkanikota R. Mani, Michael Gillette
  • PROTEOGENOMIC METHODS FOR DIAGNOSING CANCER
    Publication number: 20220326241
    Abstract: Methods disclosed herein concern cancer proteogenomics, which integrates genomics, transcriptomics and mass spectrometry (MS)-based proteomics to gain insights into cancer biology and treatment efficacy. To promote clinical utility of embodiments herein, proteogenomics approaches were developed for frozen core needle biopsies using tissue-sparing specimen processing with or without a microscaled proteomics workflow.
    Type: Application
    Filed: August 12, 2020
    Publication date: October 13, 2022
    Inventors: Matthew J. Ellis, Bing Zhang, Eric Jaehnig, Steven Carr, Shankha Satpathy, Michael Gillette
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20210322405
    Abstract: The present disclosure provides for compositions and methods of treating cancer. In some embodiments, PTPN11 is targeted with and anti-PTPN11 drug, such as a Shp2 inhibitor (e.g., SHP099). In some embodiments, other upregulated, hyperphosphorylated, or hyperacetylated target proteins are inhibited or targeted.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Inventors: Li Ding, Song Cao, Yige Wu, Alla Karpova, Liang-Bo Wang, Milan Chheda, Feng Chen, Ramaswamy Govindan, Albert Kim, Michael Gillette, Steven Carr, Shankha Satpathy, Tao Liu, Karin D. Rodland, Richard D. Smith
  • Methods and devices for tuberculosis diagnosis using biomarker profiles
    Patent number: 9702886
    Abstract: The invention relates to tuberculosis diagnostic methods and devices that measure particular biomarker profiles in subjects and identify a subject having tuberculosis based on such profiles.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: July 11, 2017
    Assignees: The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Rushdy Ahmad, Michael Gillette, Steven A. Carr
  • METHODS AND DEVICES FOR TUBERCULOSIS DIAGNOSIS USING BIOMARKER PROFILES
    Publication number: 20150148247
    Abstract: The invention relates to tuberculosis diagnostic methods and devices that measure particular biomarker profiles in subjects and identify a subject having tuberculosis based on such profiles.
    Type: Application
    Filed: May 24, 2013
    Publication date: May 28, 2015
    Applicants: The Broad Institute, Inc., The General Hospital Corporati d/b/a Massachusetts General Hospital
    Inventors: Rushdy Ahmad, Michael Gillette, Steven A. Carr