Patents by Inventor Michael GILLMEISTER

Michael GILLMEISTER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMPROVED PRODUCTION OF RECOMBINANT POLYPEPTIDES AND VIRUSES
    Publication number: 20240084329
    Abstract: Provided herein are improved methods for producing a recombinant polypeptide or virus particle. In some embodiments, a method for producing a recombinant polypeptide or virus particle disclosed herein comprises providing a cell culture comprising cells capable of producing the recombinant polypeptide or virus particle and dextran sulfate, and transfecting the cells by adding to the culture a composition comprising one or more polynucleotides and a transfection reagent. In some embodiments, the recombinant virus particle is a recombinant AAV (rAAV) particle.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 14, 2024
    Inventors: Michael GILLMEISTER, Stephen VAUGHN
  • SCALABLE METHOD FOR RECOMBINANT AAV PRODUCTION
    Publication number: 20210163991
    Abstract: Provided herein are improved methods for producing recombinant Adeno-Associated Virus (rAAV) particles. In some embodiments, a method for producing recombinant AAV (rAAV) particles provided herein comprises culturing cells capable of producing rAAV particles in the presence of a histone deacetylase (HDAC) inhibitor. In some embodiments, a method for producing recombinant AAV (rAAV) particles provided herein comprises culturing cells capable of producing rAAV particles in the presence of a histone deacetylase (HDAC) inhibitor and increased amount of a sodium salt.
    Type: Application
    Filed: August 9, 2019
    Publication date: June 3, 2021
    Inventors: Michael GILLMEISTER, Miguel VALLE, Robert STADELMAN, Franz GERNER, Matthieu GUIBERT, Bhargavi KONDRAGUNTA