Abstract: A clot capture system for disengaging a clot from a vessel wall and removing the clot from the vessel. The system may include a clot capture device for placement on a distal side of a clot. The clot capture device may have a retracted delivery configuration and an expanded deployed configuration. The clot removal device may have a proximal support frame, and a distal fiber net. The support frame may have a retracted delivery configuration and an expanded deployed configuration. The proximal support frame in the expanded configuration may define a proximal inlet mouth for engaging a clot and a net for confining the clot. An elongate member may facilitate capture and/or withdrawal of a clot from a vessel.

Abstract: A clot removal device for removing clot from a body vessel includes an expandable structure having a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration, the expandable structure including a proximal section comprising a plurality of struts with opening angles; a mid-section distal of the proximal section and comprising a plurality of struts with opening angles and cells larger than cells of the proximal section, the mid-section being configured to expand a larger radial extent in the deployed configuration than the proximal section to provide clot grip and retention during retraction of the clot; wherein the proximal section is configured to pinch the clot from the body vessel when partially resheathed by a microcatheter.

Abstract: A clot retrieval device for removing clot from a blood vessel, including a shaft extending between a proximal end and a distal end; a first expandable body coupled to the distal end of the shaft, the first expandable body comprising a plurality of scaffolding segments forming closed cells, wherein at least one of the clot scaffolding segments terminates in a distal apex free from connection to an adjacent closed cell; a second expandable body distal of the first expandable body and comprising a plurality of scaffolding segments forming closed cells; and at least one clot inlet mouth between the first and second expandable bodies and the distal apex through which clot may pass and enter the device.

Abstract: Methods and systems for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to achieve a clinically effective revascularization or perfusion rate.

Abstract: A system may comprise a clot engagement element having a collapsed delivery configuration and an expanded configuration for engaging with a clot and for dislodging the clot from a first vessel segment. An elongate member may be configured to apply a pull force to the clot engaging element to dislodge the clot from the first vessel segment. A clot removal catheter may include a lumen at its distal end sized to receive the clot and configured to maintain a stable position in a second blood vessel segment proximal of and larger in diameter than the first blood vessel segment. A distal end of the elongate member may be configured to protect a third blood vessel segment between the first and second blood vessel segments from tractive forces transmitted by the elongate member during clot dislodgement from the first vessel segment.

Abstract: An endovascular medical system for use with a clot located in a target vessel. The system including a guidewire formed by a core wire. The guidewire extending in a longitudinal direction from a proximal end to an opposite atraumatic clot-circumventing configured distal end; and a lateral direction of the atraumatic clot-circumventing configured distal end of the guidewire being defined transverse to the longitudinal direction of the guidewire. The atraumatic clot-circumventing configured distal end is designed to prevent injury to an inner wall of the target vessel and prohibit insertion of any portion of the guidewire into a perforator vessel.

Abstract: A clot retrieval device for removing clot from a blood vessel including a plurality of ring elements comprising a plurality of struts forming one or more closed cells having one or more crown elements and attached together by connecting tethers at connection points, a plurality of openings through which clot may pass and enter the device, each opening being disposed between respective ring elements. Each ring element can be self-expandable from a collapsed configuration to an expanded configuration wherein a radial force biases the ring elements toward the expanded configuration. At least one of the crown element terminates in an apex away from a center axis of the device.

Abstract: A clot retrieval device for removing clot from a blood vessel, including a shaft; a plurality of expandable bodies distal of the shaft, each expandable body comprising a plurality of scaffolding segments forming closed cells, wherein at least one of the clot scaffolding segments terminates in a distal apex free from connection to an adjacent closed cell; and a plurality of clot inlet mouths between expandable bodies through which clot may pass and enter the device.

Abstract: A rapid exchange (RX) catheter may provide a proximal seal against a guide catheter inner lumen so that aspiration may be applied through a guide catheter. The catheter may include an exit port that defines a transfer port for aspiration and may enable minimal frictional engagement with the guide catheter proximal of the exit port. Aspiration can be applied to the lumen of the guide catheter and may be directed to and effective at the tip of the RX aspiration catheter. A tip of the RX catheter may facilitate aspiration and retrieval of the clot by expanding under load and can also partially or fully occlude the vessel.

Abstract: A clot retrieval device for removing an occlusive clot from a blood vessel. The device includes a clot engagement section having a constrained delivery configuration and an expanded deployed configuration, wherein in the expanded deployed configuration. The clot engagement section can include a plurality of peak sections configured to vary contact pressure between the clot and the device along a length of the device; and a plurality of troughs between respective peak sections comprising a clot reception space. Each peak is configured to exert a relatively high compressive force on the clot whereas each trough is configured to exert little or no compressive force on the clot.

Abstract: A self-expandable mechanical clot retrieval device is designed variously to dislodge, engage and retract blood clot from extremely small and tortuous vasculature. The retrieval device comprises an elongate member and a plurality of ring elements. The ring elements may comprise a plurality of struts and crowns interconnected by a tether formed at a distal end of the elongate member or may be a separate component attached thereto. At least one tether may connect each ring element to the elongate member to restrain the ring element in a collapsed configuration during delivery of the retrieval device through an intravascular microcatheter. The tether connecting the ring element to the elongate member disengages when the retrieval device is positioned at the occluded site and the microcatheter is retracted to allow the self-expandable ring elements to reach an expanded configuration.

Abstract: A clot retrieval device may include an elongate member and an expandable clot engaging element configured to extend across the clot in its expanded state. The expandable clot engaging element may include a first monolithic structure and a second monolithic structure. The first monolithic structure may encircle the second monolithic structure over at least a portion of its length. The second monolithic structure may include a proximal section, an intermediate section, and a distal section. The distal section may include an expansion.

Abstract: A method of removing clot from a vessel, including delivering a clot retrieval device across the clot, wherein the clot retrieval device includes an inner body having a collapsed delivery configuration and an expanded deployed configuration; and an outer body extending along a longitudinal axis and at least partially overlying the inner body. The outer body includes a first scaffolding section, a second scaffolding section hingedly connected distal of the first scaffolding section; the first and second scaffolding sections of the outer body being expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space between the inner and outer bodies. The method also includes expanding the clot retrieval device; and urging, by the expanding of the first and second scaffolding sections, at least a portion of the clot therebetween.

Abstract: A system for removing occlusive clot from a blood vessel comprises a catheter and an apparatus for generating a pulsatile vacuum force to pulse the pressure gradient at a distal end of the catheter. The pulse generator may be integral with or separate from the vacuum pump. The pulse generator may be applied to a flexible tubing between the vacuum pump and the proximal end of the catheter.

Abstract: A device including a clot engaging device having a collapsed delivery configuration and an expanded deployment configuration. The device can include a plurality of struts defining a plurality of cells; a seam extending along at least a portion of a length of a distal end of the clot engaging device, wherein the seam comprises a pattern configured for gripping a clot and extends between cells of the plurality of cells; and a distal scaffolding region being distally tapered, wherein the distal scaffolding region comprises cells smaller than cells of a remainder of the clot engaging device.

Abstract: A reperfusion device for an occluded vessel. The device includes a framework of struts that form a porous body comprising a collapsed delivery configuration capable of being stored in a microcatheter and an expanded deployed configuration when delivered to an occlusion and distal of the microcatheter. The framework of struts is constructed from a material visible under fluoroscopy and capable of recovering its shape in the expanded deployed configuration once released from the collapsed delivery configuration in the microcatheter.

Abstract: A clot retrieval device for removal of occlusive clot from a blood vessel comprises a clot engaging element 700 having a constrained delivery configuration and an expanded deployed configuration. In the expanded configuration peripheral portions are laterally spaced-apart and the clot engaging section 700 extends between the peripheral portions. The device 700 may have two superimposed wave patterns provided by a large amplitude curve 723 and shorter pitch sinusoidal patterns 721, 722. A wave shape varies the contact pressure between a clot and the device along the length of the device, reducing the compression of the clot by the device at some locations. The device can elongate when placed under tension which aids elongation of the clot during dislodgement.

Abstract: A clot retrieval device comprising an elongate shaft having a proximal end and a distal end and a clot retrieval element at the distal end of the elongate shaft. A proximal end of the elongate shaft of the clot retrieval device is adapted for retraction of a first catheter over the clot retrieval device elongate shaft. A second catheter is advanced to or adjacent to the distal end of the clot retrieval device shaft to enable enhanced aspiration adjacent to the clot retrieval element.

Abstract: A clot retrieval device comprises an elongate shaft 104 and an expandable clot retrieval element 2101 on the shaft, the clot retrieval element comprising a framework formed from a substrate material such as Nitinol and having a plurality of struts 2105 and crowns 2102, at least some of the struts 2105 comprises at least one widened portion 2104 of the substrate material to provide enhanced radiopacity. The framework is coated with a radiopaque material such as gold. The device is rendered radiopaque with reduced damping effects.

Abstract: A clot capture catheter comprises an elongate tubular shaft having a proximal end, a distal end and an inflatable expansile member at the distal end. The expansile member is inflatable from a collapsed delivery configuration to an expanded configuration. In the expanded configuration, the expansile member extends to define a funnel shape having an enlarged distal clot entry mouth at the distal-most end of the catheter. In the expanded configuration, the expansile member may extend distally beyond the distalmost tip of the shaft. The expansile member may be integral with the distal tip of the catheter shaft.