Patents by Inventor Michael Givskov
Michael Givskov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12114659Abstract: The invention relates to a method for controlling of a biofilm, for removing a formed biofilm and/or for controlling a growth of microorganisms, preferably bacteria, in an aqueous environment of an industrial manufacturing process comprising cellulosic fibre material. In the method a composition comprising a compound selected from a group consisting of 3-[(4-methylphenyl)sulphonyl]-2-propenenitrile and 4-amino-N-2-thiazolyl-benzenesulphonamide is administered to the aqueous environment of the process.Type: GrantFiled: July 26, 2022Date of Patent: October 15, 2024Assignees: Kemira Oyj, University of CopenhagenInventors: Jaakko Simell, Marko Kolari, Michael Givskov, Tim Tolker-Nielsen, Morten Levin Rybtke, Jens Bo Andersen
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Publication number: 20230321043Abstract: The present invention relates to c-di-GMP lowering chemical compounds having anti- biofilm properties. In particular, the present invention relates to anti-biofilm compounds or salts or tautomers thereof for use in treatment and/or prevention of bacterial biofilm infection in human subjects caused by biofilm-forming bacteria of the genus Pseudomonas, in particular Pseudomonas spp. including P. aeruginosa. Methods of treating such infections in human subjects are contemplated as well. The present inventions further relates to the use of an anti-biofilm compound or a salt or tautomer thereof for dispersing biofilms in industrial water systems.Type: ApplicationFiled: August 27, 2021Publication date: October 12, 2023Inventors: Michael Givskov, Tim Tolker-Nielsen, Jens Bo Andersen, Tim Holm-Jakobsen, Louise Dahl Hultqvist, Carl Martin Peter Nilsson, Thomas Eiland Nielsen, Katrine Qvortrup
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Publication number: 20220361497Abstract: The invention relates to a method for controlling of a biofilm, for removing a formed biofilm and/or for controlling a growth of microorganisms, preferably bacteria, in an aqueous environment of an industrial manufacturing process comprising cellulosic fibre material. In the method a composition comprising a compound selected from a group consisting of 3-[(4-methylphenyl)sulphonyl]-2-propenenitrile and 4-amino-N-2-thiazolyl-benzenesulphonamide is administered to the aqueous environment of the process.Type: ApplicationFiled: July 26, 2022Publication date: November 17, 2022Inventors: Jaakko Simell, Marko Kolari, Michael Givskov, Tim Tolker-Nielsen, Morten Levin Rybtke, Jens Bo Andersen
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Patent number: 11490621Abstract: Disclosed is a method for controlling a biofilm, for removing a formed biofilm and/or for controlling a growth of microorganisms, preferably bacteria, in an aqueous environment of an industrial manufacturing process including cellulosic fibre material. In the method, a composition including a compound selected from a group consisting of 3-[(4-methylphenyl)sulphonyl]-2-propenenitrile and 4-amino-N-2-thiazolyl-benzenesulphonamide is administered to the aqueous environment of the process.Type: GrantFiled: August 28, 2018Date of Patent: November 8, 2022Assignees: Kemira Oyj, University of CopenhagenInventors: Jaakko Simell, Marko Kolari, Michael Givskov, Tim Tolker-Nielsen, Morten Levin Rybtke, Jens Bo Andersen
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Publication number: 20210127677Abstract: Disclosed is a method for controlling a biofilm, for removing a formed biofilm and/or for controlling a growth of microorganisms, preferably bacteria, in an aqueous environment of an industrial manufacturing process including cellulosic fibre material. In the method, a composition including a compound selected from a group consisting of 3-[(4-methylphenyl)sulphonyl]-2-propenenitrile and 4-amino-N-2-thiazolyl-benzenesulphonamide is administered to the aqueous environment of the process.Type: ApplicationFiled: August 28, 2018Publication date: May 6, 2021Applicants: Kemira Oyj, University of CopenhagenInventors: Jaakko Simell, Marko Kolari, Michael Givskov, Tim Tolker-Nielsen, Morten Levin Rybtke, Jens Bo Andersen
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Patent number: 10603289Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.Type: GrantFiled: May 15, 2018Date of Patent: March 31, 2020Assignee: DANMARKS TEKNISKE UNIVERSITETInventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
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Publication number: 20180360773Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.Type: ApplicationFiled: May 15, 2018Publication date: December 20, 2018Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
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Patent number: 9988380Abstract: The invention relates to compounds for use as quorum sensing inhibitors, and in particular, to quorum sensing inhibitors of Pseudomonas aeruginosa.Type: GrantFiled: March 10, 2014Date of Patent: June 5, 2018Assignees: Nanyang Technological University, National University of SingaporeInventors: Michael Givskov, Liang Yang, Yang Yi Sean Tan
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Publication number: 20160220736Abstract: The present invention relates to modified polymer surfaces capable of releasing bioactive agents and a method for preventing cell growth on a surface. Thus, one aspect of the invention relates to a medical device comprising a device substrate having a surface, a polymer coating attached to said surface, and a bioactive agent covalently attached to said polymer coating, and wherein said bioactive agent is covalently attached to said polymer coating via at least one ester or carboxylic acid anhydride moiety sensitive to cleavage by an enzyme. Another aspect of the present invention relates to a method of inhibiting or preventing cell growth on a surface comprising modifying said surface with a polymer coating comprising a bioactive agent covalently attached to said polymer coating.Type: ApplicationFiled: September 3, 2014Publication date: August 4, 2016Inventors: Thomas Eiland Nielsen, Vitaly V. Komnatnyy, Michael Givskov, Tim Tolker-Nielsen
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Publication number: 20150353545Abstract: The invention relates to compounds for use as quorum sensing inhibitors, and in particular, to quorum sensing inhibitors of Pseudomonas aeruginosa.Type: ApplicationFiled: March 10, 2014Publication date: December 10, 2015Inventors: Michael Givskov, Liang Yang, Yang Yi Sean Tan
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Publication number: 20140303070Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.Type: ApplicationFiled: December 7, 2011Publication date: October 9, 2014Applicant: DANMARKS TEKNISKE UNIVERSITETInventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
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Publication number: 20040147595Abstract: The present invention relates to a method for the regulation and control of biofilm layers. In particular, the present invention is concerned with methods for degrading or causing sloughing of biofilms from surfaces. The invention is also related to compositions suitable for use in carrying out these methods.Type: ApplicationFiled: March 31, 2004Publication date: July 29, 2004Inventors: Steffan Kjelleberg, Michael Givskov, Mortan Hentzer
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Patent number: 6555356Abstract: A method and microbial culture medium for inhibiting homoserine lactone and/or acylated homoserine lactone regulated processes in microorganisms using furanone compounds.Type: GrantFiled: March 4, 1998Date of Patent: April 29, 2003Assignee: Unisearch LimitedInventors: Staffan Kjelleberg, Peter David Steinberg, Peter Canisius De Nys, Ria Maximilien, Michael Manefield, Michael Givskov, Lone Gram
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Publication number: 20020037578Abstract: The present invention relates to receptor/reporter fusion protein based assays for detecting an effect test compounds have on a particular membrane receptor, as well as to receptor/reporter fusion proteins for use in such assays and compounds identified by the assays as having interesting/useful effects. Suitable membrane receptors are growth factor receptors, cytokine receptors, ion channels and integrins including any subtypes, mutants, homologs and chimeric forms of such receptors. The assay is particularly suited to studying G-protein coupled receptors (GPCRs).Type: ApplicationFiled: March 4, 1998Publication date: March 28, 2002Inventors: STAFFAN KJELLEBERG, PETER DAVID STEINBERG, PETER CANISIUS DE NYS, RIA MAXIMILIEN, MICHAEL MANEFIELD, MICHAEL GIVSKOV, LONE GRAM
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Patent number: 6017730Abstract: The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations of cells containing, in addition to such a regulatably expressible gene, a DNA coding for an immunologically active, pesticidally active or environmental pollutant-degrading gene product, may be useful in immunologically active compositions, pesticidally active compositions and environmental pollutant-degrading compositions, respectively.Type: GrantFiled: May 4, 1998Date of Patent: January 25, 2000Assignee: GX BioSystems A/SInventors: Soren Molin, Michael Givskov, Claus Sternberg Kristensen, Asim K. Bej, Leo Eberl
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Patent number: 5834233Abstract: The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations of cells containing, in addition to such a regulatably expressible gene, a DNA coding for a pesticidally active or environmental pollutant-degrading gene product, may be useful in pesticidally active compositions and environmental pollutant-degrading compositions, respectively.Type: GrantFiled: October 18, 1995Date of Patent: November 10, 1998Assignee: GX BioSystems A/SInventors: Soren Molin, Michael Givskov, Claus Sternberg Kristensen, Asim K. Bej, Leo Eberl
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Patent number: 5173418Abstract: Extracellular Serratia spp. enzymes have been found to be excreted by another gram-negative organism harbouring a plasmid carrying DNA from Serratia spp. encoding the enzymes. This organism, e.g. E. coli, is therefore employed to produce the enzymes, specific examples of Serratia spp. enzymes produced are a nuclease, a lipase and a phosopholipase. The nuclease may be employed to remove nucleic acids from a biological material.Type: GrantFiled: February 7, 1990Date of Patent: December 22, 1992Assignee: Benzon Pharma, A/SInventors: Soren Molin, Michael Givskov, Erik Riise