Patents by Inventor Michael Givskov

Michael Givskov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210127677
    Abstract: Disclosed is a method for controlling a biofilm, for removing a formed biofilm and/or for controlling a growth of microorganisms, preferably bacteria, in an aqueous environment of an industrial manufacturing process including cellulosic fibre material. In the method, a composition including a compound selected from a group consisting of 3-[(4-methylphenyl)sulphonyl]-2-propenenitrile and 4-amino-N-2-thiazolyl-benzenesulphonamide is administered to the aqueous environment of the process.
    Type: Application
    Filed: August 28, 2018
    Publication date: May 6, 2021
    Applicants: Kemira Oyj, University of Copenhagen
    Inventors: Jaakko Simell, Marko Kolari, Michael Givskov, Tim Tolker-Nielsen, Morten Levin Rybtke, Jens Bo Andersen
  • Patent number: 10603289
    Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: March 31, 2020
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
  • Publication number: 20180360773
    Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
    Type: Application
    Filed: May 15, 2018
    Publication date: December 20, 2018
    Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
  • Patent number: 9988380
    Abstract: The invention relates to compounds for use as quorum sensing inhibitors, and in particular, to quorum sensing inhibitors of Pseudomonas aeruginosa.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: June 5, 2018
    Assignees: Nanyang Technological University, National University of Singapore
    Inventors: Michael Givskov, Liang Yang, Yang Yi Sean Tan
  • Publication number: 20160220736
    Abstract: The present invention relates to modified polymer surfaces capable of releasing bioactive agents and a method for preventing cell growth on a surface. Thus, one aspect of the invention relates to a medical device comprising a device substrate having a surface, a polymer coating attached to said surface, and a bioactive agent covalently attached to said polymer coating, and wherein said bioactive agent is covalently attached to said polymer coating via at least one ester or carboxylic acid anhydride moiety sensitive to cleavage by an enzyme. Another aspect of the present invention relates to a method of inhibiting or preventing cell growth on a surface comprising modifying said surface with a polymer coating comprising a bioactive agent covalently attached to said polymer coating.
    Type: Application
    Filed: September 3, 2014
    Publication date: August 4, 2016
    Inventors: Thomas Eiland Nielsen, Vitaly V. Komnatnyy, Michael Givskov, Tim Tolker-Nielsen
  • Publication number: 20150353545
    Abstract: The invention relates to compounds for use as quorum sensing inhibitors, and in particular, to quorum sensing inhibitors of Pseudomonas aeruginosa.
    Type: Application
    Filed: March 10, 2014
    Publication date: December 10, 2015
    Inventors: Michael Givskov, Liang Yang, Yang Yi Sean Tan
  • Publication number: 20140303070
    Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
    Type: Application
    Filed: December 7, 2011
    Publication date: October 9, 2014
    Applicant: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
  • Publication number: 20040147595
    Abstract: The present invention relates to a method for the regulation and control of biofilm layers. In particular, the present invention is concerned with methods for degrading or causing sloughing of biofilms from surfaces. The invention is also related to compositions suitable for use in carrying out these methods.
    Type: Application
    Filed: March 31, 2004
    Publication date: July 29, 2004
    Inventors: Steffan Kjelleberg, Michael Givskov, Mortan Hentzer
  • Patent number: 6555356
    Abstract: A method and microbial culture medium for inhibiting homoserine lactone and/or acylated homoserine lactone regulated processes in microorganisms using furanone compounds.
    Type: Grant
    Filed: March 4, 1998
    Date of Patent: April 29, 2003
    Assignee: Unisearch Limited
    Inventors: Staffan Kjelleberg, Peter David Steinberg, Peter Canisius De Nys, Ria Maximilien, Michael Manefield, Michael Givskov, Lone Gram
  • Publication number: 20020037578
    Abstract: The present invention relates to receptor/reporter fusion protein based assays for detecting an effect test compounds have on a particular membrane receptor, as well as to receptor/reporter fusion proteins for use in such assays and compounds identified by the assays as having interesting/useful effects. Suitable membrane receptors are growth factor receptors, cytokine receptors, ion channels and integrins including any subtypes, mutants, homologs and chimeric forms of such receptors. The assay is particularly suited to studying G-protein coupled receptors (GPCRs).
    Type: Application
    Filed: March 4, 1998
    Publication date: March 28, 2002
    Inventors: STAFFAN KJELLEBERG, PETER DAVID STEINBERG, PETER CANISIUS DE NYS, RIA MAXIMILIEN, MICHAEL MANEFIELD, MICHAEL GIVSKOV, LONE GRAM
  • Patent number: 6017730
    Abstract: The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations of cells containing, in addition to such a regulatably expressible gene, a DNA coding for an immunologically active, pesticidally active or environmental pollutant-degrading gene product, may be useful in immunologically active compositions, pesticidally active compositions and environmental pollutant-degrading compositions, respectively.
    Type: Grant
    Filed: May 4, 1998
    Date of Patent: January 25, 2000
    Assignee: GX BioSystems A/S
    Inventors: Soren Molin, Michael Givskov, Claus Sternberg Kristensen, Asim K. Bej, Leo Eberl
  • Patent number: 5834233
    Abstract: The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations of cells containing, in addition to such a regulatably expressible gene, a DNA coding for a pesticidally active or environmental pollutant-degrading gene product, may be useful in pesticidally active compositions and environmental pollutant-degrading compositions, respectively.
    Type: Grant
    Filed: October 18, 1995
    Date of Patent: November 10, 1998
    Assignee: GX BioSystems A/S
    Inventors: Soren Molin, Michael Givskov, Claus Sternberg Kristensen, Asim K. Bej, Leo Eberl
  • Patent number: 5173418
    Abstract: Extracellular Serratia spp. enzymes have been found to be excreted by another gram-negative organism harbouring a plasmid carrying DNA from Serratia spp. encoding the enzymes. This organism, e.g. E. coli, is therefore employed to produce the enzymes, specific examples of Serratia spp. enzymes produced are a nuclease, a lipase and a phosopholipase. The nuclease may be employed to remove nucleic acids from a biological material.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: December 22, 1992
    Assignee: Benzon Pharma, A/S
    Inventors: Soren Molin, Michael Givskov, Erik Riise