Patents by Inventor Michael Glen Orchard

Michael Glen Orchard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MACROCYCLIC COMPOUNDS
    Publication number: 20230365514
    Abstract: The present invention relates to macrocyclic compounds which are capable of selective binding to a target saccharide (e.g. glucose), making them particularly well suited for use in saccharide sensing applications. The present invention also relates to processes for the preparation of said compounds, to compositions and devices comprising them, and to their use in the detection of a target saccharide.
    Type: Application
    Filed: October 7, 2022
    Publication date: November 16, 2023
    Inventors: Anthony Peter Davis, Robert Tromans, Miriam Ruth Wilson, Michael Glen Orchard, Andrew Michael Chapman, Michael Roger Tomsett, Johnathan Vincent Matlock
  • MACROCYCLIC COMPOUNDS
    Publication number: 20200399232
    Abstract: The present invention relates to macrocyclic compounds which are capable of selective binding to a target saccharide (e.g. glucose), making them particularly well suited for use in saccharide sensing applications. The present invention also relates to processes for the preparation of said compounds, to compositions and devices comprising them, and to their use in the detection of a target saccharide.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 24, 2020
    Inventors: Anthony Davis, Robert Tromans, Miriam Ruth Wilson, Michael Glen Orchard, Andrew Michael Chapman, Michael Roger Tomsett, Johnathan Vincent Matlock
  • Macrocyclic compounds
    Patent number: 10800747
    Abstract: The present invention relates to macrocyclic compounds which are capable of selective binding to a target saccharide (e.g. glucose), making them particularly well suited for use in saccharide sensing applications. The present invention also relates to processes for the preparation of said compounds, to compositions and devices comprising them, and to their use in the detection of a target saccharide.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: October 13, 2020
    Assignee: ZIYLO LTD
    Inventors: Anthony Davis, Robert Tromans, Miriam Ruth Wilson, Michael Glen Orchard, Andrew Michael Chapman, Michael Roger Tomsett, Johnathan Vincent Matlock
  • MACROCYCLIC COMPOUNDS
    Publication number: 20200017454
    Abstract: The present invention relates to macrocyclic compounds which are capable of selective binding to a target saccharide (e.g. glucose), making them particularly well suited for use in saccharide sensing applications. The present invention also relates to processes for the preparation of said compounds, to compositions and devices comprising them, and to their use in the detection of a target saccharide.
    Type: Application
    Filed: March 15, 2018
    Publication date: January 16, 2020
    Inventors: Anthony Davis, Robert Tromans, Miriam Ruth Wilson, Michael Glen Orchard, Andrew Michael Chapman, Michael Roger Tomsett, Johnathan Vincent Matlock
  • Pharmaceutically active piperidine derivatives
    Patent number: 9199935
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: December 1, 2015
    Assignee: Acetelion Pharmaceuticals Ltd.
    Inventors: Terence D. Butters, Raymond A. Dwek, George W. J. Fleet, Michael Glen Orchard, Frances Mary Platt
  • PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES
    Publication number: 20140303208
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Application
    Filed: April 7, 2014
    Publication date: October 9, 2014
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Terence D. BUTTERS, Raymond A. DWEK, George W. J. FLEET, Michael Glen ORCHARD, Frances Mary PLATT
  • Pharmaceutically active piperidine derivatives
    Patent number: 8729099
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: May 20, 2014
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Terence D. Butters, Raymond A. Dwek, George W. J. Fleet, Michael Glen Orchard, Frances Mary Platt
  • Substituted aniline derivatives
    Patent number: 8624022
    Abstract: The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: January 7, 2014
    Assignee: UCB Pharma, S.A.
    Inventors: Andrew David Carr, Judi Charlotte Neuss, Michael Glen Orchard, David William Porter
  • Substituted Aniline Derivatives
    Publication number: 20120029188
    Abstract: The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.
    Type: Application
    Filed: October 7, 2011
    Publication date: February 2, 2012
    Applicant: UCB Pharma S.A.
    Inventors: Andrew David Carr, Judi Charlotte Neuss, Michael Glen Orchard, David William Porter
  • Substituted aniline derivatives
    Patent number: 8071582
    Abstract: The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: December 6, 2011
    Assignee: UCB Pharma S.A.
    Inventors: Andrew David Carr, Judi Charlotte Neuss, Michael Glen Orchard, David William Porter
  • 2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide
    Patent number: 8071780
    Abstract: The present invention provides novel piperidine derivatives of formula (I), wherein R represents a substituted benzyl group, which are useful as inhibitors of glucosylceramide synthase (GCS). The compounds of the Invention are useful for treating various glycolipid storage diseases, such as Gaucher's disease, Sandhoff's disease, Tay-Schs disease, Fabry disease, and GM1 gangliosidosis; glycolipid accumulation disorders, such as Niemann-Pick disease, mucopolysaccharidoses, mucolipidosis type IV and ?-mannosidosis; various cancers that involve abnormal glycolipid synthesis; and various infectious diseases that involve cell surface glycolipids as receptors for the infectious organisms or for their toxins; as well as a variety of other disorders involving glycolipid synthesis, including neuronal disorders, inflammatory diseases, obesity, and the like.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: December 6, 2011
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventor: Michael Glen Orchard
  • 2-hydroxymethy1-3,4,5-trihydroxy-1-(4-pentyloxybenzyl) piperidine as glucosylceramide synthase (Gcs) inhibitor
    Patent number: 8022219
    Abstract: The present invention relates to the compound 3,4,5-piperidinetriol, 2-(hydroxymethyl)-1-[(4-(pentyloxy)phenyl)methyl]-, (2S,3S,4R,5S), or a pharmaceutically acceptable salt or prodrug thereof, which is useful as an inhibitor of glucosylceramide synthase. The compounds of the Invention are useful for treating various glycolipid storage diseases, such as Gaucher's disease, Sandhoff's disease, Tay-Sacs disease, Fabry disease, and GM1 gangliosidosis; glycolipid accumulation disorders, such as Niemann-Pick disease, mucopolysaccharidoses, mucolipidosis type IV and ?-mannosidosis; various cancers that involve abnormal glycolipid synthesis; and various infectious diseases that involve cell surface glycolipids as receptors for the infectious organisms or for their toxins; as well as a variety of other disorders involving glycolipid synthesis, including neuronal disorders, inflammatory diseases, obesity, and the like.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: September 20, 2011
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Michael Glen Orchard, David Ian Carter Scopes
  • Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
    Patent number: 7994198
    Abstract: Compounds of formula (I); wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: August 9, 2011
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Mezher Hussein Ali, Michael Glen Orchard
  • Piperidinetriol derivatives as inhibitors of glycosyceramid synthase
    Patent number: 7985760
    Abstract: Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: July 26, 2011
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Mezher Hussein Ali, Michael Glen Orchard
  • Substituted Aniline Derivatives
    Publication number: 20110014271
    Abstract: The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.
    Type: Application
    Filed: January 13, 2010
    Publication date: January 20, 2011
    Applicant: UCB PHARMA S.A.
    Inventors: Andrew David CARR, Judi Charlotte NEUSS, Michael Glen ORCHARD, David William PORTER
  • Substituted aniline derivatives
    Patent number: 7678785
    Abstract: The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: March 16, 2010
    Assignee: UCB Pharma S.A.
    Inventors: Andrew David Carr, Judi Charlotte Neuss, Michael Glen Orchard, David William Porter
  • Piperidine Derivatives as Gcs Inhibitors
    Publication number: 20080234324
    Abstract: The present invention relates to novel piperidine derivatives that are useful as inhibitors of glucosylceramide synthase (GCS) for use in the treatment and prevention of diseases or disorders mediated by GCS, including cancer, infectious diseases, neuronal disorders or injury and inflammatory diseases. The invention further relates to the pharmaceutical composition comprising the novel piperidine derivatives and methods for preparing the same.
    Type: Application
    Filed: January 11, 2005
    Publication date: September 25, 2008
    Inventors: Michael Glen Orchard, David Ian Carter Scopes
  • Benzylidene thiazolidinediones and their use as antimycotic agents
    Patent number: 7105554
    Abstract: A compound of formula I or a salt thereof wherein, A is O or S, X and Y independently represent O, CH2 and may be the same or different, Q is (CH2)m—CH(R1)-(CH2)n, R is OR6, NHR8, R1 is hydrogen, or optionally substituted alkyl, R2 and R3 are independently hydrogen, or specific substituents, provided that R2 and R3 are not both H, and R4 and R5 are hydrogen or specific substituents, m is 0–3; n is 0–2; are useful in the treatment of fungal infections.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: September 12, 2006
    Assignee: Oxford Glycosciences (UK) Ltd.
    Inventors: Michael Glen Orchard, Judi Charlotte Neuss, Carl Maurice Swedler Galley
  • Thiazolidine derivatives and its use as antifungal agent
    Patent number: 6740670
    Abstract: Compounds of formula (I) or salts thereof are provided wherein X is O or S, A and B are OR2 or Y—NR3R4 wherein when A is OR2. B is Y—NR3R4 and vice versa, or when one of A or B is OR2. then the other can be CO2R7. Y is CH2 or C═Q. Q is (CH2)m—CH(R1)—(CH2)n, R is OR6 or NHR7 and with the other definitions as set out in claim 1, a process for its preparation and its use in the prophylaxis or treatment of fungal infections.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: May 25, 2004
    Assignee: Oxford Glycosciences (UK) Ltd.
    Inventors: Michael Glen Orchard, Judi Charlotte Neuss
  • Pharmaceutically active piperidine derivatives
    Publication number: 20040097551
    Abstract: Compounds of formula (I): 1
    Type: Application
    Filed: July 11, 2003
    Publication date: May 20, 2004
    Inventors: Terence D. Butters, Raymond A. Dwek, George WJ Fleet, Michael Glen Orchard, Frances Mary Platt