Abstract: The present disclosure provides a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: A gap blocking system includes a loading platform having a gap separating a first portion of the loading platform from a second portion of the loading platform. A ride vehicle is coupled to a transport extending through the gap. The gap blocking system also includes a panel assembly coupled to the loading platform and comprising a plurality of panels, wherein each panel of the plurality of panels is coupled to a respective biasing mechanism coupled to the first portion of the loading platform and configured to bias each panel towards a closed configuration in which each panel extends radially away from the first portion of the loading platform.

Abstract: One aspect of the present disclosure discloses a probe, including a probe body having a center axis defining a proximal end and a distal end and including an aperture in the distal end; a window affixed in the aperture, wherein the window is substantially optically transparent; and a flange adjoining the proximal end of the probe body, the flange including a sealing surface and a sealing edge, wherein the flange separates an in-process portion of the probe from an ex-process portion of the probe, the in-process portion including at least the probe body, the sealing surface and the sealing edge, where at least the in-process portion of the probe consists essentially of an austenitic stainless steel material. Further aspects include a computer product configured to execute a method employing the probe.

Abstract: A vehicle tailgate assembly primarily for pick-up trucks comprises a frame with a transverse base and support arms extending perpendicularly therefrom adjacent distal ends of the base. A tailgate door is rotationally mounted to the frame between the support arms. The door comprises a transverse upper section rotationally joined to a transverse lower section at a rotational joint, preferably a hinge. A releasable locking mechanism, typically a latch or multiple latches, is located adjacent the rotational joint to releasably hold the upper section in relation to the lower section at selected orientations. An additional locking mechanism, also typically a latch or multiple latches, may selectively hold the lower section or both the lower section and the upper section to the support arms. The tailgate may also be provided with an extendible tailgate which may be rotated interiorly and exteriorly of the plane of the upper section.

Abstract: A system and method for customized scheduling of sources, including breaking down a source of content into at least two categories, including posts and engagements, and gathering content related to a specific source. A scheduler handles scheduling of posts and engagement for a single source and entities that are due to be crawled are sent to a scheduling queue, in which each content type for a source can have its own queue. A process points to the correct scheduler queue in order to request content to be crawled, attaches to the proper queue, processes requests, queries the social network for content, parses the response and sends any new data to be saved to the system.

Abstract: A vehicle tailgate with an integrated collapsible door comprises a tailgate having an outer wall, an inner wall and a cavity there between, a door section located in an upper portion of the tailgate having an inboard wall and an outboard wall and being moveable between a closed position and an open position substantially within an envelope of the tailgate, the door section comprising means to vary the spacing between the inboard wall and the outboard wall, the means to vary the spacing between the inboard wall and the outboard wall comprising at least one rotatable cam element located within the door section, such that when the door section is in the closed position the inboard wall is flush with the inner wall and the outboard wall is flush with the outer wall and when the door section is in the open position the spacing between the inboard wall and the outboard wall is reduced to allow a portion of the door section to be received in the cavity.

Abstract: Methods, systems, and devices are described for configuration of multiple power distribution units (PDUs) in an efficient manner. Power distribution units may be discovered on a network, and automatically configured according to a configuration defined for a particular location. A location may be, for example, a geographical region, a data center, a zone within a data center, a cabinet, or an individual PDU. All PDUs associated with a particular location may be provided with a common configuration file that defines operating parameters for the PDUs. In such a manner, a user may simply connect the PDU to the network, with the appropriate configuration provided without additional involvement of the user.

Abstract: High-voltage insulators are disclosed that are capable of handling diverse requirements, such as providing high standoff voltages, high temperature cycling, and the ability to withstand flexural stress. One high-voltage insulator includes a first piece formed from a first material, a second piece formed from a second material, and an interface section where the first piece contacts with and forms a seal with the second piece. The interface includes a first groove located that accommodates a first gasket, sets of matching threads on the first and second pieces. The interface section further accommodates a second gasket. In this multi-piece high-voltage insulator, the first material can have a first set of flexural, heat resistance, and electrical standoff characteristics suitable for a first environment, and the second material can have a second set of flexural, heat resistance and electrical standoff characteristics suitable for a second environment.

Abstract: A system for sequential circumferential deposition of thermoplastic composite prepreg material to layer plies of prepreg tape, allowing the continuous processing of tubular shapes and rods, comprising a floating mandrel; a first heatable folding shoe configured to heat and wrap a first prepreg tape onto the floating mandrel; a first forming tube configured to heat and pultrude the first prepreg tape so as to form a first layer ply of prepreg tape on the floating mandrel; a second heatable folding shoe configured to heat and wrap a second prepreg tape onto the first layer ply of prepreg tape on the floating mandrel; a second forming tube configured to heat and pultrude the second prepreg tape so as to form a second layer ply of prepreg tape over the first layer ply of prepreg tape on the floating mandrel.

Abstract: Apparatuses, systems, and methods for a wireless device and a cellular base station to support common analog beam steering for band groups. The wireless device may provide an indication of analog beam steering capability of the wireless device to the cellular base station. For example, the wireless device may support a limited number of analog beams for each of one or more band groups. The cellular base station may select beam configuration information for the wireless device based at least in part on the indication of analog beam steering capability of the wireless device. This may include selecting a common beam for multiple component carriers for the wireless device based on the wireless device’s analog beam steering capability. The cellular base station may provide the beam configuration information to the wireless device.

Abstract: A gap blocking system includes a loading platform having a gap separating a first portion of the loading platform from a second portion of the loading platform. A ride vehicle is coupled to a transport extending through the gap. The gap blocking system also includes a panel assembly coupled to the loading platform and comprising a plurality of panels, wherein each panel of the plurality of panels is coupled to a respective biasing mechanism coupled to the first portion of the loading platform and configured to bias each panel towards a closed configuration in which each panel extends radially away from the first portion of the loading platform.

Abstract: This patent relates to hinged devices, such as computing devices. One example includes a first portion and a second portion. A dynamic fulcrum hinge includes a flexible material extending between the first portion and the second portion and configured to begin rotation proximate to the first portion and finish rotation proximate to the second portion when the first portion is rotated toward the second portion.

Abstract: An electronic device includes a first portion, a second portion, and a third portion. A torque-optional hinge connects the third portion to the second portion, and a support hinge connects the third portion to the first portion. The torque-optional hinge has a hinge axis and a means for selectively generating a torque around the hinge axis. The means for selectively generating the torque has a high-torque state and a low-torque state. The high-torque state provides a greater rotational resistance around the hinge axis than the low-torque state. The support hinge rotatably connects the first portion and the third portion and provides a torque around a support axis.

Abstract: A vehicle tailgate with an integrated collapsible door comprises a tailgate having an outer wall, an inner wall and a cavity there between, a door section located in an upper portion of the tailgate having an inboard wall and an outboard wall and being moveable between a closed position and an open position substantially within an envelope of the tailgate, the door section comprising means to vary the spacing between the inboard wall and the outboard wall, the means to vary the spacing between the inboard wall and the outboard wall comprising at least one rotatable cam element located within the door section, such that when the door section is in the closed position the inboard wall is flush with the inner wall and the outboard wall is flush with the outer wall and when the door section is in the open position the spacing between the inboard wall and the outboard wall is reduced to allow a portion of the door section to be received in the cavity.

Abstract: A journey through a waterway along which a sea-faring vessel manually piloted is identified and stored. A second vessel is later autonomously navigated along the same journey based on the stored data.

Abstract: The description relates to hinged devices, such as hinged computing devices. One example can include first and second portions that rotate around a hinge shaft that is fixedly secured to the first portion and rotationally secured to the second portion. The second portion defining a first contact surface spaced apart from a second contact surface. Multiple friction clips friction fit around the hinge shaft and rotating with the hinge shaft between the first contact surface and the second contact surface.

Abstract: Antiviral drugs targeting the N-terminal domain (NTD) of the spike receptor binding domain (RBD) and methods of treating a subject suffering from coronavirus.

Abstract: Inhibitors against SARS-COV-1, SARS-CoV-2 (Covid-19), MERS-CoV, and variants within each, including methods of treating a subject suffering from such respiratory disease.

Abstract: Methods, systems, and devices are described for configuration of multiple power distribution units (PDUs) in an efficient manner. Power distribution units may be discovered on a network, and automatically configured according to a configuration defined for a particular location. A location may be, for example, a geographical region, a data center, a zone within a data center, a cabinet, or an individual PDU. All PDUs associated with a particular location may be provided with a common configuration file that defines operating parameters for the PDUs. In such a manner, a user may simply connect the PDU to the network, with the appropriate configuration provided without additional involvement of the user.