Abstract: A method of assembling a trigger sprayer assembly includes providing an engine having a piston chamber and a fluid passage that is fluidly coupled to the piston chamber, the fluid passage extending from an input portion to an output portion. The method further includes inserting a piston component into the piston chamber, and coupling a trigger lever to the engine and the piston component. Pivoting the trigger lever relative to the engine pushes and pulls the piston component within the piston chamber to drive fluid from the input portion to the output portion of the fluid passage. The method further includes coupling a shroud to the engine, where the coupling comprises positioning a rail protrusion of the engine within a corresponding recess formed in the shroud, and inserting a shelf extending from an interior surface of the shroud into a pair of receiving clips extending from the engine.

Abstract: Provided are systems and methods for producing seamless woven materials that are variable in each of their 3 dimensions. The systems and methods generally operate by altering heddle positions independently to impart three dimensional structure to a woven fabric. Weft yarn is woven into a set of warp yarns that have been individually raised or lowered along a particular cross section, essentially locking the weave into an intended 3 dimensional form.

Abstract: Provided herein are methods of predicting a likelihood of survival following treatment with AA and prednisone in a patient having CRPC.

Abstract: Provided are methods of treating prostate cancer in a human male comprising administration of apalutamide and androgen deprivation therapy to a human male having prostate cancer (e.g., nmCRPC) if a biological sample obtained from the human male is determined to have a specific molecular subtype of prostate cancer, a specific classifier score, or increased or decreased expression of a signature class. The molecular subtypes include luminal-like or basal-like molecular subtype. Also provided are methods of using molecular signatures and genomic classifier scores, such as four co-regulated signature classes, metastasis risk based on a genomic classifier score, or a combination thereof, as prognostic indicators of apalutamide and androgen deprivation therapy in human males having prostate cancer, for improved treatment benefit.

Abstract: A positive air pressure attenuation device (1) comprising:—a housing (3) with an inner central portion (6) forming a channel (7); and an elastic flexible inflatable reservoir (8) associated to the inner central portion (6), whereby the inner central portion (6) has a wall portion (60) with a plurality of openings (61) forming passages between the channel (7) and the reservoir chamber (8A).

Abstract: Provided are methods of treating prostate cancer in a human male comprising administration of apalutamide and androgen deprivation therapy to a human male having prostate cancer (e.g., nmCRPC) if a biological sample obtained from the human male is determined to have a specific molecular subtype of prostate cancer, a specific classifier score, or increased or decreased expression of a signature class. The molecular subtypes include luminal-like or basal-like molecular subtype. Also provided are methods of using molecular signatures and genomic classifier scores, such as four co-regulated signature classes, metastasis risk based on a genomic classifier score, or a combination thereof, as prognostic indicators of apalutamide and androgen deprivation therapy in human males having prostate cancer, for improved treatment benefit.

Abstract: A positive air pressure attenuation device (1) comprising:—a housing (3) with an inner central portion (6) forming a channel (7); and an elastic flexible inflatable reservoir (8) associated to the inner central portion (6), whereby the inner central portion (6) has a wall portion (60) with a plurality of openings (61) forming passages between the channel (7) and the reservoir chamber (8A).

Abstract: Provided are whole blood based mRNA biomarkers for predicting prostate cancer and methods of detecting the same. The disclosed mRNA markers and methods enable the identification/diagnosis of a patient with prostate cancer, identification of a patient with/prediction of high-risk prostate cancer, and treatment of a patient with prostate cancer. Also provided are gene chips comprising the disclosed whole blood based mRNA biomarkers.

Abstract: A device for protecting a person, comprising a light source, sound source, and a network transceiver. The device is configured to, upon activation by a switch, to emit light and sound at respective frequencies and connect to a mobile device to cause the mobile device to send one or more messages to one or more other devices. The messages can comprise one or more of a location of the device, an identity of a user of the device and a status message.

Abstract: A portable device for storing a token for providing a product or service to a user is disclosed. The device comprises a memory for storing one or more tokens, means for detecting a tag associated with the product or service and for receiving data from the tag. In response to detecting the tag, the device receives data from the tag, determines a provider code of the product or service based on the received data, determines a location code associated with a region in which the device is located; and identifies a token stored within the storage means based on the determined provider code and location code.

Abstract: Provided herein are methods of predicting a likelihood of survival following treatment with AA and prednisone in a patient having CRPC.

Abstract: A recoiling tethered golf ball has a first hole extending through the ball center and a second hole extending at right angles to the first hole. A nail in the second hole extends beyond the first hole into the golf ball. An anchor has an elongated shaft tapering to a point for insertion into the ground. The upper end is formed into an eye. The anchor has optional threads for attachment to a board or tree. A surgical tubing tether extends from a first end to a second end. The first end is received in the golf ball first hole and is looped around the nail. The tether second end is looped around the anchor eye. A first retaining clip encircles the first end loop. A second retaining clip encircles the second end loop to secure the loop from releasing.

Abstract: A carbonating device for carbonating an opened vessel including an inlet valve for receiving pressurized gas, an exit valve for expelling gas into a vessel to be carbonated, a trigger for opening the inlet valve, a trigger pressure regulator arranged to close the inlet valve, a discharge assembly, and a cap assembly, the discharge assembly coupled to and de-coupled from the cap and including a port for discharging gas to the cap, the discharge port being opened and closed by a valve and a pressure regulator arranged to automatically close the discharge valve in response to a pressure level.

Abstract: A carbonating device for carbonating an opened vessel including an inlet valve for receiving pressurised gas, an exit valve for expelling gas into a vessel to be carbonated, a trigger for opening the inlet valve, a trigger pressure regulator arranged to close the inlet valve, a discharge assembly, and a cap assembly, the discharge assembly coupled to and de-coupled from the cap and including a port for discharging gas to the cap, the discharge port being opened and closed by a valve and a pressure regulator arranged to automatically close the discharge valve in response to a pressure level.

Abstract: The method includes the following steps—introducing a low amplitude air pressure transient into the drainage and vent system of a building in order to propagate a pressure wave from a fitting (6) into a stack (1) and the network of the drainage system;—recording the passage of the transient by use of an air pressure transducer (7) located near the fitting (6) or introduction area of the transient;—establishing a pressure versus time signature recorded by the pressure transducer (7) and sending those signals to a central data acquisition system;—the pressure transient is propagated throughout the network at an acoustic velocity and is reflected by each and every pipe termination of the network so as to establish a characteristic reflection coefficient for each pipe termination; —the characteristic reflection coefficient is compared with testing results performed initially in a perfect network with no dry trap defects or leakages and in case a different signature is of the pressure trace is recorded, the point

Abstract: A recoiling tethered golf ball has a first hole extending through the ball center and a second hole extending at right angles to the first hole. A nail in the second hole extends beyond the first hole into the golf ball. An anchor has an elongated shaft tapering to a point for insertion into the ground. The upper end is formed into an eye. The anchor has optional threads for attachment to a board or tree. A surgical tubing tether extends from a first end to a second end. The first end is received in the golf ball first hole and is looped around the nail. The tether second end is looped around the anchor eye. A first retaining clip encircles the first end loop. A second retaining clip encircles the second end loop to secure the loop from releasing.

Abstract: A carbonated drink container pressurizer adapter that is screwed onto a conventional drink container in place of the original bottle top, which includes a valve attachment point for the purpose of allowing entry of CO2, and a pressure release valve preset to open at a given pressure for the safe use of the adapter.

Abstract: The method includes the following steps—introducing a low amplitude air pressure transient into the drainage and vent system of a building in order to propagate a pressure wave from a fitting (6) into a stack (1) and the network of the drainage system; —recording the passage of the transient by use of an air pressure transducer (7) located near the fitting (6) or introduction area of the transient; —establishing a pressure versus time signature recorded by the pressure transducer (7) and sending those signals to a central data acquisition system; —the pressure transient is propagated throughout the network at an acoustic velocity and is reflected by each and every pipe termination of the network so as to establish a characteristic reflection coefficient for each pipe termination; —the characteristic reflection coefficient is compared with testing results performed initially in a perfect network with no dry trap defects or leakages and in case a different signature is of the pressure trace is recorded, the poi

Abstract: A computer system for creating and managing a database of communication recipients which processes queries and otherwise operates in accordance with user commands to perform telemarketing, mass mailing, direct mailing and other communication functions. The computer is programmed to create automatic salutations, to automatically generate lists of carbon copy recipients, and to export data from the database to word processing systems for merging with text. In addition, the computer is programmed to analyze new records to ensure they are not duplicates of existing records. A user is provided with options to keep one or both records, or to combine both records into a new record. The computer is programmed to retrieve records on the basis of queries using one or more defined codes which can be ANDed and ORed together in accordance with Boolean logic, among other functions.

Abstract: A computer system for creating and managing a database of communication recipients which processes queries and otherwise operates in accordance with user commands to perform telemarketing, mass mailing, direct mailing and other communication functions. The computer is programmed to create automatic salutations, to automatically generate lists of carbon copy recipients, and to export data from the database to word processing systems for merging with text. In addition, the computer is programmed to analyze new records to ensure they are not duplicates of existing records. A user is provided with options to keep one or both records, or to combine both records into a new record. The computer is programmed to retrieve records on the basis of queries using one or more defined codes which can be ANDed and ORed together in accordance with Boolean logic, among other functions.