Patents by Inventor Michael GOTTSCHALDT

Michael GOTTSCHALDT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11530296
    Abstract: The invention relates to new cationic polymers conjugated with D-fructose, as a result of which they can selectively interact with specific structure elements on cell surfaces. The problem was that of creating novel, biocompatible, easy-to-produce, D-fructose-conjugated cationic polymers that have a higher selectivity with respect to certain cell types. To solve this problem, the invention proposes cationic polymers with covalently bonded D-fructose of general formula (I) with the following components: a) cationic polymer: macromolecular compounds of n repeat units with one or more positive charges; b) linker: a unit that links the cationic polymer with D-fructose or derivatives of D-fructose by means of any alkyl or aryl group, any alkenyl or alkinyl group, an ether, thioether or amine, an ester, amide or other carboxylic acid derivative, a heterocycle (e.g.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: December 20, 2022
    Assignee: FRIEDRICH-SCHILLER-UNIVERSITAET JENA
    Inventors: Michael Gottschaldt, Michael Proehl, Christoph Englert, Ulrich Sigmar Schubert
  • Publication number: 20200407502
    Abstract: The invention relates to new cationic polymers conjugated with D-fructose, as a result of which they can selectively interact with specific structure elements on cell surfaces. The problem was that of creating novel, biocompatible, easy-to-produce, D-fructose-conjugated cationic polymers that have a higher selectivity with respect to certain cell types. To solve this problem, the invention proposes cationic polymers with covalently bonded D-fructose of general formula (I) with the following components: a) cationic polymer: macromolecular compounds of n repeat units with one or more positive charges; b) linker: a unit that links the cationic polymer with D-fructose or derivatives of D-fructose by means of any alkyl or aryl group, any alkenyl or alkinyl group, an ether, thioether or amine, an ester, amide or other carboxylic acid derivative, a heterocycle (e.g.
    Type: Application
    Filed: March 23, 2018
    Publication date: December 31, 2020
    Inventors: Michael GOTTSCHALDT, Michael PROEHL, Christoph ENGLERT, Ulrich Sigmar SCHUBERT
  • Patent number: 9795688
    Abstract: The invention relates to a nanostructured delivery system comprising at least one polymer and/or at least one lipid and at least one polymethine dye, wherein the at least one polymethine dye acting as a targeting unit brings about the targeted transport of the nanostructured delivery system into a target issue. The invention also relates to a pharmaceutical composition and the uses of the nanostructured delivery system for transporting said system and, optionally, a pharmaceutical active ingredient into the target tissue, as well for treating liver and/or kidney diseases.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: October 24, 2017
    Assignee: SMARTDYELIVERY GMBH
    Inventors: Michael Bauer, Ulrich Schubert, Michael Gottschaldt, Anja Trager, Christian Pietsch, Falk Gonnert, Peter Recknagel, Adrian Press
  • Publication number: 20170166697
    Abstract: Poly(ethylene imine)-based copolymers especially suited for bonding to the releasing genetic material, in particular DNA/RNA are of the general Formula I and are produced through a synthesis of the general Formula III:
    Type: Application
    Filed: October 2, 2014
    Publication date: June 15, 2017
    Inventors: Christoph ENGLERT, Lutz TAUHARDT, Michael GOTTSCHALDT, Ulrich S. SCHUBERT
  • Publication number: 20160220697
    Abstract: The invention relates to a nanostructured delivery system comprising at least one polymer and/or at least one lipid and at least one polymethine dye, wherein the at least one polymethine dye acting as a targeting unit brings about the targeted transport of the nanostructured delivery system into a target issue. The invention also relates to a pharmaceutical composition and the uses of the nanostructured delivery system for transporting said system and, optionally, a pharmaceutical active ingredient into the target tissue, as well for treating liver and/or kidney diseases.
    Type: Application
    Filed: September 11, 2014
    Publication date: August 4, 2016
    Inventors: Michael BAUER, Ulrich SCHUBERT, Michael GOTTSCHALDT, Anja TRAGER, Christian PIETSCH, Falk GONNERT, Peter RECKNAGEL, Adrian PRESS