Patents by Inventor Michael Grabarnick
Michael Grabarnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11632954Abstract: The present subject matter provides a crystalline form of the compound having the following structure: wherein the crystalline form is a polymorph, hydrate or solvate.Type: GrantFiled: July 16, 2018Date of Patent: April 25, 2023Assignee: ADAMA MAKHTESHIM LTD.Inventors: Michael Grabarnick, Gal Suez, Zoltán Német, Samaa Alasibi
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Publication number: 20200229437Abstract: The present subject matter provides a crystalline form of the compound having the following structure: wherein the crystalline form is a polymorph, hydrate or solvate.Type: ApplicationFiled: July 16, 2018Publication date: July 23, 2020Applicant: ADAMA MAKHTESHIM LTD.Inventors: Michael Grabarnick, Gal Suez, Zoltán Német, Samaa Alasibi
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Patent number: 10377720Abstract: A process for preparing, 2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]-N-hydroxy-benzenamine of formula (I) comprising: mixing 1-(4-chlorophenyl)-3-[(2 -nitrophenyl)methoxy]-1H-pyrazole of formula (II) with a nitrogen-containing base, a sulfur compound, a solvent and a platinum-based catalyst in the presence of hydrogen.Type: GrantFiled: May 9, 2016Date of Patent: August 13, 2019Assignee: Adama Makhteshim Ltd.Inventors: Gal Suez, Michael Grabarnick, Alexander Frenklah, Heinz Steiner
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Publication number: 20190152921Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: January 25, 2019Publication date: May 23, 2019Applicant: ADAMA MAKHTESHIM LTD.Inventors: Anat Levin, Michael Grabarnick
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Publication number: 20180282286Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: May 29, 2018Publication date: October 4, 2018Applicant: ADAMA MAKHTESHIM LTD.Inventors: Anat Levin, Michael Grabarnick
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Publication number: 20180155294Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: February 2, 2018Publication date: June 7, 2018Applicant: ADAMA MAKHTESHIM LTD.Inventors: Anat Levin, Michael Grabarnick
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Patent number: 9868709Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid and hydrogen peroxide in the presence of a strong acid.Type: GrantFiled: November 30, 2016Date of Patent: January 16, 2018Inventors: Omer Tzor, Michael Grabarnick
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Publication number: 20170320832Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: July 25, 2017Publication date: November 9, 2017Applicant: ADAMA MAKHTESHIM LTD.Inventors: Anat Levin, Michael Grabarnick
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Publication number: 20170121290Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: January 17, 2017Publication date: May 4, 2017Applicant: ADAMA MAKHTESHIM LTD.Inventors: Anat Levin, Michael Grabarnick
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Publication number: 20170081299Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: November 30, 2016Publication date: March 23, 2017Inventors: Omer TZOR, Michael GRABARNICK
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Patent number: 9546142Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid, acetic anhydride and hydrogen peroxide in the presence of a strong acid.Type: GrantFiled: October 13, 2014Date of Patent: January 17, 2017Inventors: Omer Tzor, Michael Grabarnick
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Publication number: 20160304467Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: June 29, 2016Publication date: October 20, 2016Applicant: ADAMA MAKHTESHIM LTD.Inventors: Anat Levin, Michael Grabarnick
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Publication number: 20160251323Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid, acetic anhydride and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: October 13, 2014Publication date: September 1, 2016Inventors: Omer TZOR, Michael GRABARNICK
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Publication number: 20150099892Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-9-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: September 12, 2014Publication date: April 9, 2015Applicant: ADAMA MAKHTESHIM LTD.Inventors: Anat Levin, Michael Grabarnick
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Publication number: 20140155620Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: February 6, 2014Publication date: June 5, 2014Applicant: IRVITA PLANT PROTECTION, A BRANCH OF CELSIUS PROPERTY B.V.Inventors: Anat LEVIN, Michael GRABARNICK
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Publication number: 20130289283Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: June 25, 2013Publication date: October 31, 2013Inventors: Anat Levin, Michael Grabarnick
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Publication number: 20130197238Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.Type: ApplicationFiled: July 10, 2011Publication date: August 1, 2013Inventors: Anat Levin, Michael Grabarnick
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Patent number: 7078465Abstract: The present invention provides a process for bromomethylation of organic compounds, wherein said process is a two stage process comprising of the following stages: a) reacting paraformaldehyde with hydrogen bromide and separating bis-bromomethyl ether (BBME) from the reaction mixture, and, b) reacting BBME obtained in stage (a) with an organic compound in the presence of a Lewis acid, to obtain the bromomethylated organic compound. Further provided by the present invention is a process for the preparation of 4,4?-bis-(diethylphosphonomethyl)-biphenyl (BPMB).Type: GrantFiled: August 29, 2001Date of Patent: July 18, 2006Assignee: Makhteshim Chemical Works, Ltd.Inventors: Michael Grabarnick, Yoel Sasson
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Publication number: 20040242799Abstract: The present invention provides a process for bromomethylation of organic compounds, wherein said process is a two stage process comprising of the following stages: a) reacting paraformaldehyde with hydrogen bromide and separating bis-bromomethyl ether (BBME) from the reaction mixture, and, b) reacting BBME obtained in stage (a) with an organic compound in the presence of a Lewis acid, to obtain the bromomethylated organic compound. Further provided by the present invention is a process for the preparation of 4,4′-bis-(diethylphosphonomethyl)-biphenyl (BPMB).Type: ApplicationFiled: July 27, 2004Publication date: December 2, 2004Inventors: Michael Grabarnick, Yoel Sasson