Patents by Inventor Michael Grabarnick

Michael Grabarnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION OF 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID
    Publication number: 20240217915
    Abstract: The present invention relates to a novel nitration process of 2-chloro-4-fluorobenzoic acid to 2-chloro-4-fluoro-5-ni-trobenzoic acid, 2-chloro-4-f luoro-3-nitrobenzoic acid and 3,5-dinitro-2-chloro-4-fluorobenzoic acid; purifying the crude reaction product; and recovering 2-chloro-4-fluoro-5-nitrobenzoic acid in an essentially pure form, which can be used in the synthesis of the herbicide saflufenacil.
    Type: Application
    Filed: March 22, 2022
    Publication date: July 4, 2024
    Applicant: ADAMA AGAN LTD.
    Inventors: Michael GRABARNICK, Ashok Kumar JHA, Revanappa Vasantrao GALGE
  • SOLID FORMS OF SAFLUFENACIL-SODIUM AND SAFLUFENACIL-POTASSIUM, PROCESS OF PREPARATION AND USE THEREOF
    Publication number: 20240174620
    Abstract: The present invention relates to novel solid forms of saflufenacil-sodium or saflufenacil-potassium. The present invention further relates to a process of making said novel solid forms of saflufenacil-sodium or saflufenacil-potassium. Still further, the present invention relates to the use of the novel solid forms of saflufenacil-sodium or saflufenacil-potassium.
    Type: Application
    Filed: March 4, 2022
    Publication date: May 30, 2024
    Inventors: Michael GRABARNICK, Sergio NAHMOUD, Daniel MELIKER, Lior ZISERMAN, Ashok Kumar JHA, Revanappa Vasantrao GALGE
  • Polymorphs of 5-fluoro-4-imino-3-methyl-1 -tosyl-3,4-dihydropyrimidin-2-one
    Patent number: 11632954
    Abstract: The present subject matter provides a crystalline form of the compound having the following structure: wherein the crystalline form is a polymorph, hydrate or solvate.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: April 25, 2023
    Assignee: ADAMA MAKHTESHIM LTD.
    Inventors: Michael Grabarnick, Gal Suez, Zoltán Német, Samaa Alasibi
  • POLYMORPHS OF 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2-ONE
    Publication number: 20200229437
    Abstract: The present subject matter provides a crystalline form of the compound having the following structure: wherein the crystalline form is a polymorph, hydrate or solvate.
    Type: Application
    Filed: July 16, 2018
    Publication date: July 23, 2020
    Applicant: ADAMA MAKHTESHIM LTD.
    Inventors: Michael Grabarnick, Gal Suez, Zoltán Német, Samaa Alasibi
  • Process for preparing a hydroxylamine pyrazole compound
    Patent number: 10377720
    Abstract: A process for preparing, 2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]-N-hydroxy-benzenamine of formula (I) comprising: mixing 1-(4-chlorophenyl)-3-[(2 -nitrophenyl)methoxy]-1H-pyrazole of formula (II) with a nitrogen-containing base, a sulfur compound, a solvent and a platinum-based catalyst in the presence of hydrogen.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: August 13, 2019
    Assignee: Adama Makhteshim Ltd.
    Inventors: Gal Suez, Michael Grabarnick, Alexander Frenklah, Heinz Steiner
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20190152921
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: January 25, 2019
    Publication date: May 23, 2019
    Applicant: ADAMA MAKHTESHIM LTD.
    Inventors: Anat Levin, Michael Grabarnick
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20180282286
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: May 29, 2018
    Publication date: October 4, 2018
    Applicant: ADAMA MAKHTESHIM LTD.
    Inventors: Anat Levin, Michael Grabarnick
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20180155294
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 7, 2018
    Applicant: ADAMA MAKHTESHIM LTD.
    Inventors: Anat Levin, Michael Grabarnick
  • Process for preparing isoxaflutole
    Patent number: 9868709
    Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: January 16, 2018
    Inventors: Omer Tzor, Michael Grabarnick
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20170320832
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: July 25, 2017
    Publication date: November 9, 2017
    Applicant: ADAMA MAKHTESHIM LTD.
    Inventors: Anat Levin, Michael Grabarnick
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20170121290
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: January 17, 2017
    Publication date: May 4, 2017
    Applicant: ADAMA MAKHTESHIM LTD.
    Inventors: Anat Levin, Michael Grabarnick
  • PROCESS FOR PREPARING ISOXAFLUTOLE
    Publication number: 20170081299
    Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 23, 2017
    Inventors: Omer TZOR, Michael GRABARNICK
  • Process for preparing isoxaflutole
    Patent number: 9546142
    Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid, acetic anhydride and hydrogen peroxide in the presence of a strong acid.
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: January 17, 2017
    Inventors: Omer Tzor, Michael Grabarnick
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20160304467
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: June 29, 2016
    Publication date: October 20, 2016
    Applicant: ADAMA MAKHTESHIM LTD.
    Inventors: Anat Levin, Michael Grabarnick
  • PROCESS FOR PREPARING ISOXAFLUTOLE
    Publication number: 20160251323
    Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid, acetic anhydride and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: October 13, 2014
    Publication date: September 1, 2016
    Inventors: Omer TZOR, Michael GRABARNICK
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20150099892
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-9-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: September 12, 2014
    Publication date: April 9, 2015
    Applicant: ADAMA MAKHTESHIM LTD.
    Inventors: Anat Levin, Michael Grabarnick
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20140155620
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: February 6, 2014
    Publication date: June 5, 2014
    Applicant: IRVITA PLANT PROTECTION, A BRANCH OF CELSIUS PROPERTY B.V.
    Inventors: Anat LEVIN, Michael GRABARNICK
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20130289283
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: June 25, 2013
    Publication date: October 31, 2013
    Inventors: Anat Levin, Michael Grabarnick
  • FIPRONIL PRODUCTION PROCESS
    Publication number: 20130197238
    Abstract: An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.
    Type: Application
    Filed: July 10, 2011
    Publication date: August 1, 2013
    Inventors: Anat Levin, Michael Grabarnick
  • Process to bromomethylate aromatic compounds
    Patent number: 7078465
    Abstract: The present invention provides a process for bromomethylation of organic compounds, wherein said process is a two stage process comprising of the following stages: a) reacting paraformaldehyde with hydrogen bromide and separating bis-bromomethyl ether (BBME) from the reaction mixture, and, b) reacting BBME obtained in stage (a) with an organic compound in the presence of a Lewis acid, to obtain the bromomethylated organic compound. Further provided by the present invention is a process for the preparation of 4,4?-bis-(diethylphosphonomethyl)-biphenyl (BPMB).
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: July 18, 2006
    Assignee: Makhteshim Chemical Works, Ltd.
    Inventors: Michael Grabarnick, Yoel Sasson