Patents by Inventor Michael Graner

Michael Graner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIAGNOSING MULTIPLE SCLEROSIS (MS)
    Publication number: 20250012795
    Abstract: Compositions and methods for diagnosing and treating multiple sclerosis (MS) and other health conditions involve collecting serum samples from a subject and exposing the serum samples to a protein capture composition, collecting the unbound eluent or flow-through, and measuring the levels of at least one immunoglobulin therein. Methods for differentiating between different types of MS also involve exposing serum samples to a protein capture composition and detecting immunoglobulin levels in the flow-through. Based on the detected immunoglobulin levels, an MS subtype is diagnosed in a subject and a treatment regimen can be adjusted or ceased according to the diagnosis.
    Type: Application
    Filed: September 29, 2022
    Publication date: January 9, 2025
    Inventors: Xiaoli Yu, Michael Graner, Wenbo Zhou, Timothy Vollmer, Enrique Alvarez
  • FUNCTIONALIZED NANOPARTICLE FORMULATIONS FOR ORAL DRUG DELIVERY
    Publication number: 20210369860
    Abstract: Drug delivery systems comprising binding partners conjugated to a nanoparticle encapsulating a therapeutic agent formulated for oral administration, and methods of delivering therapeutic agents across the gastrointestinal epithelium.
    Type: Application
    Filed: October 24, 2019
    Publication date: December 2, 2021
    Inventors: Thomas ANCHORDOQUY, Michael GRANER, Jamie BETKER, Brittany ANGLE
  • Methods of recovering chaperone proteins and complexes thereof
    Patent number: 6875849
    Abstract: The present invention provides methods for efficient and concomitant recovery of multiple chaperone proteins and/or chaperone protein complexes from a limited sample source. Disclosed are methods involving the use of Free Solution Iso-Electric Focusing (FS-IEF) which can enrich samples containing chaperone proteins and/or chaperone protein complexes from a given sample. The chaperone proteins can be, but are not restricted to calreticulin, gp96, hsp86, hsp84, hsp70, hsp60 and hsp40. The invention also provides methods of recovering chaperone protein complexes for the preparation of vaccines containing chaperone complexes.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: April 5, 2005
    Assignee: Arizona Board of Regents of behalf of The University of Arizona
    Inventors: Michael Graner, Emmanuel Katsanis
  • Methods of recovering chaperone proteins and complexes thereof
    Publication number: 20030031661
    Abstract: The present invention provides methods for efficient and concomitant recovery of multiple chaperone proteins and/or chaperone protein complexes from a limited sample source. Disclosed are methods involving the use of Free Solution Iso-Electric Focusing (FS-IEF) which can enrich samples containing chaperone proteins and/or chaperone protein complexes from a given sample. The chaperone proteins can be, but are not restricted to calreticulin, gp96, hsp86, hsp84, hsp70, hsp60 and hsp40. The invention also provides methods of recovering chaperone protein complexes for the preparation of vaccines containing chaperone complexes.
    Type: Application
    Filed: March 5, 2002
    Publication date: February 13, 2003
    Inventors: Michael Graner, Emmanuel Katsanis