Abstract: Vasculature modeling systems and methods are disclosed that generate an enhanced 3D model based on a combination of two dimensional, 2D, imaging data of a region of interest and 3D imaging data of the region of interest. A hemodynamic simulation is performed using the enhanced 3D model to derive at least one hemodynamic parameter based on the hemodynamic simulation.

Abstract: An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface (40) and a processing unit (50). The input interface is configured to obtain image data (30) representing a two-dimensional representation of a vessel (6). The processing unit (50) is configured to determine a course of the vessel (6) and a width (w1, w2) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.

Abstract: Systems and related methods to estimate, for a liquid dynamic system, flow or resistance based on a model of an object and pressure measurements collected in-situ at said object. Alternatively, pressure flow measurements are collected and pressure or resistance is being estimated.

Abstract: An apparatus for assessing a patient-s vasculature is provided which is adapted to derive a physiological model of the vasculature including a geometric model and a fluid dynamics model of a vessel of interest and a dynamics measure indicative of a contrast agent dynamics through the vasculature from a plurality of diagnostic images and to analyze the at least one dynamics measure as the function of time such as to adjust at least one boundary condition of the fluid dynamics model.

Abstract: A medical imaging system (200) includes a masking unit (234), an image registration unit (238), a motion estimator (240) and a motion compensating reconstructor (244). The masking unit constructs a mask for each reconstructed volumetric phase image of a plurality of reconstructed volumetric phase images that masks portions of a corresponding image external to an anatomical model fitted to a segmented at least one anatomical structure, 5 wherein the plurality of reconstructed volumetric phase images include a target phase and a plurality of temporal neighboring phases reconstructed from projection data. The image registration unit registers the masked reconstructed volumetric phase images. The motion estimator estimates motion between the target phase and the plurality of temporal neighboring phases according to the model based on the registered masked reconstructed 10 volumetric phase images.

Abstract: A three-dimensional morphological vessel model (20) can be obtained by assigning diameters (14,15) along the vessel derived from a two-dimensional morphological projection (10) at locations in the three-dimensional model defined by the temporal locations (21,22) of a trackable instrument (5). An apparatus (7), a system (1) and a method (100) for use of the system (1) in characterizing the vessel of a living being (2) by rendering a three-5 dimensional morphological vessel model (20) are presented.

Abstract: A process prepares dialkyl 1,4-cyclohexanedicarboxylates by ring hydrogenation of the corresponding dialkyl terephthalate having a CO value of less than 0.3 mg KOH/g. The dialkyl 1,4-cyclohexanedicarboxylates thus produced can be used as plasticizers or as a component of a plasticizer composition for plastics, in particular PVC.

Abstract: A method and apparatus for selecting one or more diagnostic images to generate a physiological model are provided in which a set of candidate images is determined for review by a user, in particular by a physician. The candidate images are hereby determined using one or more target measures, such as a density measure, a motion measure, a deviation measure or the like, that have been derived for each diagnostic image of an X-ray angiography series and by analyzing said target measure. Subsequently, a suitability score that is based on the requirements of the physiological model that shall be generated from the selected candidate images is assigned to each candidate image.

Abstract: The invention relates to an apparatus configured to display an aortic valve image and an indicator when the aortic valve is in its open-state and/or when the valve is in its closed-state. The indicator is supposed to be in an overlay to the image of the aortic valve, such that a physician can see on the same display image the information needed to advance a guide wire or catheter through the aortic valve of a heart. This may prevent damaging ensures not to damage the aortic valve. The physician receives the relevant information, when the aortic valve is in its open-state and thus being in a state to be passed by the catheter. The information, whether the aortic valve is in its open-state or in its closed-state, corresponds to the systolic phase and the distal phase of the heart, respectively. The information, when the heart is in its systolic phase and when it is in the diastolic phase may be extracted from an ECG measurement.

Abstract: The invention relates to an active marker device (100) for being introduced into a human tissue and for tracking a region of interest of a human body. The active marker device comprises a light source (101) for emitting light such that the emitted light can be detected by an optical sensor. In this way, the active marker device and/or the region of interest can be tracked by a tracking system comprising the optical sensor. The active marker device (100) further comprises a switch (102) for turning the light source on and off and for operating the light source in a pulsed mode.

Abstract: The present invention relates to an apparatus (10) for designing or configuring a guide for a bronchoscope or guiding sheath. It is described to providing (310) a processing unit with at least one diagnostic image of a patient, wherein the at least one diagnostic image comprises image data of a region of interest and image data of the bronchial tree or vascular system in the vicinity of the region of interest. The processing unit determines (320) a position of the region of interest. The processing unit determines (330) a position in the bronchial tree or vascular system from which an intervention is to be carried out via a bronchoscope or guiding sheath. The intervention will comprise movement of a part of an intervention device towards the region of interest, wherein the bronchoscope or guiding sheath is configured such that the part of the intervention device can exit an end of the bronchoscope or guiding sheath.

Abstract: The present invention relates to a device (1) for providing image data during an extraction procedure for extracting a lead from the body of a subject using an extraction device (7). The device comprises an input (2) for receiving live x-ray projection image data of the lead during the extraction procedure and for receiving three-dimensional image data as acquired before the extraction procedure. A processing unit (3) determines a position of the extraction device (7) in the three-dimensional image data by detecting the position in the live projection image data during the procedure and correlates this position in the live projection image data with the position in the three-dimensional image data. An output (4) generates an image of a cross-sectional view of the lead and/or its surrounding body structure at the determined position based on the three-dimensional image data.

Abstract: An apparatus for assessing a vessel of interest and a corresponding method are provided in which the modeling of the hemodynamic parameters using a fluid dynamics model can be verified by deriving feature values from the segmented vessel of interest and inputting these feature values into a classifier. The classifier may then determine, based on the feature values whether the segmentation has been performed from proximal to distal, from distal to proximal or cannot be determined from the provided data. An incorrect segmentation order can thus be identified and potentially be corrected, thereby avoiding inaccurate simulation results.

Abstract: An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface (40) and a processing unit (50). The input interface is configured to obtain image data (30) representing a two-dimensional representation of a vessel (6). The processing unit (50) is configured to determine a course of the vessel (6) and a width (w1, w2) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.

Abstract: The present invention is directed towards a system and method for transarterial chemoembolization using differently sized drug-eluting microsphere beads filled with drugs and determining a delivered drug concentration using an imaging system.

Abstract: Systems and related methods to estimate, for a liquid dynamic system, flow or resistance based on a model of an object and pressure measurements collected in-situ at said object. Alternatively, pressure flow measurements are collected and pressure or resistance is being estimated.

Abstract: An image processing system (IPS), comprising an input interface (IN) for receiving a projection image from a plurality of projection images of a movable object (PAT) acquired along different directions by an imaging apparatus (XA), the projection images defined in a projection domain spanned by a radiation sensitive surface of the detector (D). The system includes a motion checker (MC) configured to operate in the projection domain to decide whether the projection image is corrupted by motion of the object during acquisition.

Abstract: The invention refers to a system for providing a spectral image using a conventional CT system. The system comprises a data providing unit (11) for providing first projection data and second projection data, wherein the first and second projection data have been acquired using different acquisition spectra, wherein the first projection data has been acquired during a scout scan and the second projection data has been acquired during a diagnostic scan, or wherein the first and second projection data have been acquired by a first and second part of the detector, respectively. The first and second part of the detector acquire projection data with different acquisition spectra. A spectral image generation unit (12) generates a spectral image based on the projection data. With this system a spectral image can be provided using a conventional CT system with a decreased acquisition time.

Abstract: The present invention relates to a device (1) for fractional flow reserve determination. The device (1) comprises a model generator (10) configured to generate a three-dimensional model (3DM) of a portion of an imaged vascular vessel tree (VVT) surrounding a stenosed vessel segment (SVS), based on a partial segmentation of the imaged vascular vessel tree (VVT). Further, the device comprises an image processor (20) configured to calculate a blood flow (Q) through the stenosed vessel segment (SVS) based on an analysis of a time-series of X-ray images of the vascular vessel tree (VVT). Still further, the device comprises a fractional-flow-reserve determiner (30) configured to determine a fractional flow reserve (FFR) based on the three-dimensional model (3DM) and the calculated blood flow.

Abstract: The present invention relates to an intra cardiac echo imaging device, an intra cardiac echo imaging system and method for assessing coronary circulation using an intra cardiac echo probe. An image of a cardiac region is received, wherein the image provides at least one or more coronary vessels and/or at least one heart chamber; at least one region of interest within the image is defined; imaging parameters of an intra cardiac echo probe are received; and at least one of a location, an orientation and access path of the intra cardiac echo probe relative to the region of interest is calculated based on: anatomical content in the region of interest and/or in the cardiac region and the imaging parameters of the intra cardiac echo probe; a roadmap and the at least one of the calculated location, orientation and access path of the intra cardiac echo probe is output to a display.