Patents by Inventor Michael Graupe

Michael Graupe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALPHA KETOAMIDE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
    Publication number: 20090170909
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: December 17, 2008
    Publication date: July 2, 2009
    Applicant: Virobay, Inc.
    Inventors: Michael Graupe, John O. Link, Michael G. Roepel
  • Alpha ketoamide compounds as cysteine protease inhibitors
    Patent number: 7488848
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: February 10, 2009
    Assignee: Virobay, Inc.
    Inventors: Michael Graupe, John O. Link, Michael G. Roepel
  • IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS
    Publication number: 20090005374
    Abstract: A compound of general Formula (I) having histone deacetylase (HDAC) and/or CDK inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
    Type: Application
    Filed: June 26, 2008
    Publication date: January 1, 2009
    Inventors: Lawrence S. Melvin, JR., Michael Graupe, Chandrasekar Venkataramani
  • Modulators of toll-like receptor 7
    Publication number: 20080008682
    Abstract: The present application provides for a compound of Formula I or II: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.
    Type: Application
    Filed: July 6, 2007
    Publication date: January 10, 2008
    Inventors: Lee Chong, Manoj Desai, Brian Gallagher, Michael Graupe, Randall Halcomb, Hong Yang, Jennifer Zhang
  • Novel Compounds and Compositions as Cathepsin Inhibitors
    Publication number: 20070135386
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: January 22, 2007
    Publication date: June 14, 2007
    Applicants: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals Inc.
    Inventors: Michael Graupe, James Palmer, David Aldous, Sukanthini Thurairatnam
  • Amidino compounds as cysteine protease inhibitors
    Publication number: 20070105892
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: December 22, 2004
    Publication date: May 10, 2007
    Applicant: AXYS Pharmaceuticals, Inc.
    Inventors: Michael Graupe, Agnes Lau, Jiayao Li, John Link, Craig Mossman, Soon H. Woo, Sheila M. Zipfel
  • Silinane compounds as cysteine protease inhibitors
    Publication number: 20070088001
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them. The present invention is also directed to the use of these inhibitors in combination with a therapy that causes a deleterious immune response in patients receiving the therapy.
    Type: Application
    Filed: January 31, 2005
    Publication date: April 19, 2007
    Inventors: John Link, Michael Graupe
  • Compounds and compositions as cathepsin inhibitors
    Patent number: 7196099
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: March 27, 2007
    Assignees: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals Inc.
    Inventors: Michael Graupe, James T. Palmer, David John Aldous, Sukanthini Thurairatnam
  • HCV Inhibitors
    Publication number: 20070054864
    Abstract: The present invention is directed to compounds that are antiviral agents. Specifically the compounds of the present invention inhibit replication of HCV and are therefore useful in treating hepatitis C infections. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: June 28, 2006
    Publication date: March 8, 2007
    Inventors: Michael Graupe, John Link, Chandrasekar Venkataramani
  • Novel compounds and compositions as cathepsin inhibitors
    Publication number: 20070049594
    Abstract: The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: December 7, 2005
    Publication date: March 1, 2007
    Applicants: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, John Patterson, David Aldous, Sukanthini Thurairatnam, Andreas Timm, John Link, Jiayao Li, Stephen Pickett, Frank Halley, Justine Lai
  • Alpha ketoamide compounds as cysteine protease inhibitors
    Publication number: 20070021353
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: March 17, 2006
    Publication date: January 25, 2007
    Applicant: Applera Corporation
    Inventors: Michael Graupe, John Link, Michael Roepel
  • Peptidic compounds as cysteine protease inhibitors
    Patent number: 7101880
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: September 5, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Michael Graupe, John O. Link
  • Compounds and compositions as cathepsin inhibitors
    Patent number: 7064123
    Abstract: The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: December 24, 2001
    Date of Patent: June 20, 2006
    Assignees: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, John W. Patterson, Stephen D. Pickett, John O. Link, Jiayao Li, David Aldous, Sukanthini Thurairatnam, Andreas P. Timm, Frank Halley, Justine Lai Yeun Quai
  • Cyanomethyl derivatives as cysteine protease inhibitors
    Publication number: 20060122184
    Abstract: The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsin B, K, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 8, 2006
    Applicant: AXYS Pharmaceuticals, Inc.
    Inventors: Michael Graupe, Agnes Lau, John Link, Yang Liu, Craig Mossman, John Patterson, Sheila Zipfel
  • Novel compounds and compositions as cathepsin inhibitors
    Publication number: 20060089357
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: December 7, 2005
    Publication date: April 27, 2006
    Applicants: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, James Palmer, John Patterson, Stephen Pickett, David Aldous, Sukanthini Thurairatnam, Andreas Timm, Frank Halley, Justine Lai, John Link, Jiayao Li
  • Compounds and compositions as cathepsin inhibitors
    Patent number: 7030116
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: April 18, 2006
    Assignees: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, James T. Palmer, John W. Patterson, David J. Aldous, Sukanthini Thurairatnam, Andreas P. Timm, John Link, Jiayao Li
  • Cysteine protease inhibitors
    Publication number: 20050288336
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine protease, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: May 14, 2003
    Publication date: December 29, 2005
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Michael Graupe, Agnes Lau, John Link, Yang Liu, Craig Mossman, John Patterson, Sheila Zipfel
  • Novel compounds and compositions as cathepsin inhibitors
    Publication number: 20040192742
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: February 26, 2004
    Publication date: September 30, 2004
    Applicants: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, James T. Palmer, David John Aldous, Sukanthini Thurairatnam
  • Novel compounds and compositions as cathepsin inhibitors
    Publication number: 20040142999
    Abstract: The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: November 21, 2003
    Publication date: July 22, 2004
    Applicants: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, Jiayao Li, John Link, Sheila Zipfel, Andreas Paul Timm, David John Aldous, Sukathini Thurairatnam
  • Peptidic compounds as cysteine protease inhibitors
    Publication number: 20040127426
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: June 24, 2003
    Publication date: July 1, 2004
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Michael Graupe, John O. Link