Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.

Abstract: A hierarchical network enables access for a stacked memory system including or more memory dies that each include multiple memory tiles. The processor die includes multiple processing tiles that are stacked with the one or more memory die. The memory tiles that are vertically aligned with a processing tile are directly coupled to the processing tile and comprise the local memory block for the processing tile. The hierarchical network provides access paths for each processing tile to access the processing tile's local memory block, the local memory block coupled to a different processing tile within the same processing die, memory tiles in a different die stack, and memory tiles in a different device. The ratio of memory bandwidth (byte) to floating-point operation (B:F) may improve 50× for accessing the local memory block compared with conventional memory. Additionally, the energy consumed to transfer each bit may be reduced by 10×.

Abstract: Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state.

Abstract: The invention describes transdermal vaccines which contain ultrasound responsive particles comprising a polypeptide shell. The surface of the particle has one or more indentations which are generally able to entrap a gas bubble. The particles are capable of generating inertial cavitation on exposure to ultrasound. The particles can be delivered transdermally, and can comprise antigen protein and/or adjuvant within the particle structure. The particles are therefore useful in methods of vaccination using transdermal delivery routes.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: The present disclosure relates generally to systems, methods, and computer-readable media for selectively identifying candidate keywords for a target domain, generating keyword clusters based on the candidate keywords, and implementing the candidate keywords within published online content. In particular, systems disclosed herein generate or otherwise obtain access to a collection of keywords and value metrics descriptive of a profile of the keywords with respect to a target domain. The systems can selectively identify candidate keywords having unique value to a domain and generate keyword clusters including the keywords and associated terms. The systems described herein can further implement the keyword clusters within a structure of published content items that are linked or otherwise associated with the target domain.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: A structural yielding link, particularly for use in an eccentrically braced frame arrangement or in a linked column frame arrangement having a first end having a means for connecting to a face of a first beam and a second end having a means for connecting to a face of a second beam; a first variable cross-section portion and a second variable cross-section portion extending from the first end and from the second end, respectively; and a constant cross-section portion joining the first variable cross-section portion and the second variable cross-section portion.

Abstract: A system and method for cybersecurity reconnaissance, analysis, and scoring that uses distributed, cloud-based computing services to provide sufficient scalability for analysis of enterprise IT networks using only publicly available characterizations. The system and method comprise an in-memory associative array which manages a queue of vulnerability search tasks through a public-facing proxy network. The public-facing proxy network has search nodes configurable to present the network to search tools in a desired manner to control certain aspects of the search to obtain the desired results. A distributed data processing engine and cloud-based storage are used to provide scalable computing power and storage. Each of the cloud-based computing services is containerized and orchestrated for management and efficient scaling purposes.

Abstract: A compact hydraulic particle separator apparatus is disclosed. The disclosed apparatus comprises an upper chamber and a lower chamber separated by a partition. A liquid fluid flow upwelling through the partition from the lower chamber is caused to mix with tangential jet of fluid flowing introduced above the partition in the upper chamber produces an upwardly-flowing cyclonic flow within the upper chamber. Particle mixtures containing low- and high-density particles and other solids are introduced into the upper chamber through a feed tube having a mouth that is offset from the center of the upper chamber. Low-density particles are immediately entrained in the cyclonic flow and swept upward and exit the apparatus.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: A method includes: accessing a set of hardware parameters characterizing an embedded device; identifying a set of supported container functions based on the set of hardware parameters; accessing a selection of container functions; identifying a set of selected container functions based on the selection of container functions and the set of supported container functions; generating a hardware abstraction layer (HAL) including a set of libraries supporting the set of selected container functions; generating a container runtime environment (CRE) configured to execute, at the embedded device, a containerized application via the HAL, the containerized application including the set of selected container functions; installing the HAL and the CRE onto the embedded device; installing the containerized application onto the embedded device via the CRE; and at the embedded device, executing the containerized application via the CRE and the HAL.

Abstract: A method includes: accessing a set of hardware parameters characterizing an embedded device; identifying a set of supported container functions based on the set of hardware parameters; accessing a selection of container functions; identifying a set of selected container functions based on the selection of container functions and the set of supported container functions; generating a hardware abstraction layer (HAL) including a set of libraries supporting the set of selected container functions; generating a container runtime environment (CRE) configured to execute, at the embedded device, a containerized application via the HAL, the containerized application including the set of selected container functions; installing the HAL and the CRE onto the embedded device; installing the containerized application onto the embedded device via the CRE; and at the embedded device, executing the containerized application via the CRE and the HAL.

Abstract: A pen apparatus with a pressure sensitive tip mechanism that internally generates pressure, tilt, and/or barrel rotation through the use of a multi-axis measurement scheme with simultaneous transmit, receive, and sensing driver capability operable in conjunction with a receiving system or in a relative stand-alone manner. Signaling schemes are provided for operating the pen apparatus to achieve improved function. Systems and methods are provided for operating a pen, and for operating a pen with a touch sensor system. Drive/receive circuitry and methods of driving and receiving sensor electrode signals are provided that allow digital I/O pins to be used to interface with touch sensor electrodes. This circuitry may be operated in modes to sense various combinations of signals coupled within a pen, or from outside of a pen.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration data sensed by a glucose concentration sensor. A host state change associated with the host glucose concentration data may be determined. A guidance message based at least in part on the host state change may also be determined. The guidance message may be delivered through a user interface.