Patents by Inventor Michael Grisham

Michael Grisham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing therapeutically active cells using microfluidics
    Patent number: 12612597
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Grant
    Filed: September 6, 2021
    Date of Patent: April 28, 2026
    Assignees: ZEON CORPORATION, UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony Ward, Roberto Campos-Gonzalez, Alison Skelley, Khushroo Gandhi, Curt Civin, James C. Sturm, Michael Grisham
  • Methods and systems for processing particles
    Patent number: 12590955
    Abstract: Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: March 31, 2026
    Assignees: ZEON CORPORATION, THE TRUSTEES OF PRINCETON UNIVERSITY, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Michael Grisham, Curt I. Civin, James C. Sturm, Robert H. Austin, Joseph D'Silva, Yu Chen
  • IMPLEMENTATION OF A DUAL FABRY-PEROT PHOTONIC PRESSURE SENSOR
    Publication number: 20260016355
    Abstract: In an aspect, a pressure sensor for determining pressure in an environment comprises: a source for emitting a coherent reference light characterized by a reference light frequency; a first lock-in mechanism configured to send an electrical signal to the source based on a reference resonance frequency; a reference cavity; wherein the reference cavity is characterized by the reference resonance frequency; a modulator configured a reference light to generate at least a first sideband frequency such that an output of said modulator is a measurement light characterized by at least the first sideband frequency; a frequency synthesizer configured to drive the modulator; a second lock-in mechanism configured to send an electrical signal to the frequency synthesizer based on a measurement resonance frequency; and a measurement cavity configured to receive at least a portion of the measurement light; wherein the measurement cavity is characterized by the measurement resonance frequency; and wherein the pressure of the
    Type: Application
    Filed: February 13, 2025
    Publication date: January 15, 2026
    Applicant: Stable Laser Systems, Inc.
    Inventors: Josue DAVILA-RODRIGUEZ, David LEE, Mark NOTCUTT, Michael GRISHAM, Nathaniel PHILLIPS
  • Methods and devices for multi-step cell purification and concentration
    Patent number: 12436081
    Abstract: Described herein are microfluidic devices and methods that can separate and concentrate particles in a sample.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: October 7, 2025
    Assignees: ZEON CORPORTION, UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony Ward, Khushroo Gandhi, Alison Skelley, Curt Civin, James C. Sturm, Lee Aurich, Michael Grisham, Joseph D'Silva, Robert H. Austin
  • Implementation of a dual Fabry-Perot photonic pressure sensor
    Patent number: 12276557
    Abstract: In an aspect, a pressure sensor for determining pressure in an environment comprises: a source for emitting a coherent reference light characterized by a reference light frequency; a first lock-in mechanism configured to send an electrical signal to the source based on a reference resonance frequency; a reference cavity; wherein the reference cavity is characterized by the reference resonance frequency; a modulator configured a reference light to generate at least a first sideband frequency such that an output of said modulator is a measurement light characterized by at least the first sideband frequency; a frequency synthesizer configured to drive the modulator; a second lock-in mechanism configured to send an electrical signal to the frequency synthesizer based on a measurement resonance frequency; and a measurement cavity configured to receive at least a portion of the measurement light; wherein the measurement cavity is characterized by the measurement resonance frequency; and wherein the pressure of the
    Type: Grant
    Filed: September 28, 2023
    Date of Patent: April 15, 2025
    Assignee: STABLE LASER SYSTEMS, INC.
    Inventors: Josue Davila-Rodriguez, David Lee, Mark Notcutt, Michael Grisham, Nathaniel Phillips
  • IMPLEMENTATION OF A DUAL FABRY-PEROT PHOTONIC PRESSURE SENSOR
    Publication number: 20240019327
    Abstract: In an aspect, a pressure sensor for determining pressure in an environment comprises: a source for emitting a coherent reference light characterized by a reference light frequency; a first lock-in mechanism configured to send an electrical signal to the source based on a reference resonance frequency; a reference cavity; wherein the reference cavity is characterized by the reference resonance frequency; a modulator configured a reference light to generate at least a first sideband frequency such that an output of said modulator is a measurement light characterized by at least the first sideband frequency; a frequency synthesizer configured to drive the modulator; a second lock-in mechanism configured to send an electrical signal to the frequency synthesizer based on a measurement resonance frequency; and a measurement cavity configured to receive at least a portion of the measurement light; wherein the measurement cavity is characterized by the measurement resonance frequency; and wherein the pressure of the
    Type: Application
    Filed: September 28, 2023
    Publication date: January 18, 2024
    Applicant: Stable Laser Systems, Inc.
    Inventors: Josue DAVILA-RODRIGUEZ, David LEE, Mark NOTCUTT, Michael GRISHAM, Nathaniel PHILLIPS
  • Implementation of a dual Fabry-Perot photonic pressure sensor
    Patent number: 11821801
    Abstract: In an aspect, a pressure sensor for determining pressure in an environment comprises: a source for emitting a coherent reference light characterized by a reference light frequency; a first lock-in mechanism configured to send an electrical signal to the source based on a reference resonance frequency; a reference cavity; wherein the reference cavity is characterized by the reference resonance frequency; a modulator configured a reference light to generate at least a first sideband frequency such that an output of said modulator is a measurement light characterized by at least the first sideband frequency; a frequency synthesizer configured to drive the modulator; a second lock-in mechanism configured to send an electrical signal to the frequency synthesizer based on a measurement resonance frequency; and a measurement cavity configured to receive at least a portion of the measurement light; wherein the measurement cavity is characterized by the measurement resonance frequency; and wherein the pressure of the
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: November 21, 2023
    Assignee: Stable Laser Systems, Inc.
    Inventors: Josue Davila-Rodriguez, David Lee, Mark Notcutt, Michael Grisham, Nathaniel Phillips
  • ON-CHIP MICROFLUIDIC PROCESSING OF PARTICLES
    Publication number: 20230280261
    Abstract: Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.
    Type: Application
    Filed: September 26, 2022
    Publication date: September 7, 2023
    Inventors: Michael GRISHAM, Curt I. CIVIN, James C. STURM, Robert H. AUSTIN, Joseph D'SILVA, Yu CHEN
  • On-chip microfluidic processing of particles
    Patent number: 11493428
    Abstract: Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 8, 2022
    Assignees: GPB SCIENTIFIC, INC., UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Michael Grisham, Curt I Civin, James C. Sturm, Robert H. Austin, Joseph D'Silva, Yu Chen
  • Methods for preparing therapeutically active cells using microfluidics
    Patent number: 11306288
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: April 19, 2022
    Assignees: GPB SCIENTIFIC, INC., UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony Ward, Roberto Campos-Gonzalez, Alison Skelley, Khushroo Gandhi, Curt Civin, James C. Sturm, Michael Grisham
  • Methods for Preparing Therapeutically Active Cells Using Microfluidics
    Publication number: 20220041985
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Application
    Filed: September 6, 2021
    Publication date: February 10, 2022
    Applicants: GPB SCIENTIFIC, INC., UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony WARD, Roberto CAMPOS-GONZALEZ, Alison SKELLEY, Khushroo GANDHI, Curt CIVIN, James C. STURM, Michael GRISHAM
  • Methods for preparing therapeutically active cells using microfluidics
    Patent number: 11149251
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: October 19, 2021
    Assignees: GPB Scientific, Inc., The Trustees of Princeton University, University of Maryland, Baltimore
    Inventors: Anthony Ward, Roberto Campos-Gonzalez, Alison Skelley, Khushroo Gandhi, Curt Civin, James C. Sturm, Michael Grisham
  • MICROFLUIDIC METHODS FOR THE PREPARATION OF CELLS
    Publication number: 20210290675
    Abstract: The present invention is directed to the use of microfluidics in the preparation of genetically transformed cells and compositions for therapeutic uses.
    Type: Application
    Filed: July 11, 2019
    Publication date: September 23, 2021
    Applicants: GPB SCIENTIFIC, INC., THE TRUSTEES OF PRINCETON UNIVERSITY, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Anthony WARD, Roberto CAMPOS-GONZALEZ, Alison SKELLEY, Khushroo GANDHI, Michael GRISHAM, Curt CIVIN, James C. STURM
  • Methods for Preparing Therapeutically Active Cells Using Microfluidics
    Publication number: 20210207094
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Application
    Filed: March 4, 2021
    Publication date: July 8, 2021
    Applicants: GPB SCIENTIFIC, INC., UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony WARD, Roberto CAMPOS-GONZALEZ, Alison SKELLEY, Khushroo GANDHI, Curt CIVIN, James C. STURM, Michael GRISHAM
  • METHODS AND DEVICES FOR MULTI-STEP CELL PURIFICATION AND CONCENTRATION
    Publication number: 20210156787
    Abstract: Described herein are microfluidic devices and methods that can separate and concentrate particles in a sample.
    Type: Application
    Filed: February 4, 2021
    Publication date: May 27, 2021
    Applicants: GPB SCIENTIFIC, INC., UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony WARD, Khushroo GANDHI, Alison SKELLEY, Curt CIVIN, James C. STURM, Lee AURICH, Michael GRISHAM, Joseph D'SILVA, Robert H. Austin
  • Methods for preparing therapeutically active cells using microfluidics
    Patent number: 10988734
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: April 27, 2021
    Assignees: GPB Scientific, Inc., The Trustees of Princeton University, University of Maryland, Baltimore
    Inventors: Anthony Ward, Roberto Campos-Gonzalez, Alison Skelley, Khushroo Gandhi, Curt Civin, James C. Sturm, Michael Grisham
  • Methods and devices for multi-step cell purification and concentration
    Patent number: 10976232
    Abstract: Described herein are microfluidic devices and methods that can separate and concentrate particles in a sample.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: April 13, 2021
    Assignees: GPB Scientific, Inc., The Trustees of Princeton University, University of Maryland, Baltimore
    Inventors: Anthony Ward, Khushroo Gandhi, Alison Skelley, Curt Civin, James C. Sturm, Lee Aurich, Michael Grisham, Joseph D'Silva, Robert H. Austin
  • Interactive electronically presented map
    Patent number: 10908782
    Abstract: The present invention provides computerized systems and methods for providing electronically presented interactive area representation, such as a map, and information associated therewith. A user can select text, imagery, or other information presented on the map and associated with one or more items or locations, causing presentation of information relating to the associated one or more items or locations, such as appropriate contact information or a hyperlink to an appropriate Web site. Additionally or alternatively, a user can input or select, based on a query or otherwise, information relating to one or more items or locations associated with text, imagery, or other information presented on the map, causing presentation of an indication of one or more locations of the associated text, imagery, or other information on the map. A magnifier feature allowing internal navigation within the map can be provided. Additionally, animated images can appear to move over the map.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: February 2, 2021
    Assignee: ACTIVEMAP LLC
    Inventors: Michael Abramson, Erika Jakubassa, Michael Grisham, Geoffrey Atkin
  • Methods for Preparing Therapeutically Active Cells Using Microfluidics
    Publication number: 20200399600
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Application
    Filed: September 2, 2020
    Publication date: December 24, 2020
    Applicants: GPB SCIENTIFIC, INC., UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Anthony WARD, Roberto CAMPOS-GONZALEZ, Alison SKELLEY, Khushroo GANDHI, Curt CIVIN, James C. STURM, Michael GRISHAM
  • Methods for preparing therapeutically active cells using microfluidics
    Patent number: 10844353
    Abstract: The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: November 24, 2020
    Assignees: GPB Scientific, Inc., The Trustees of Princeton University, University of Maryland, Baltimore
    Inventors: Anthony Ward, Roberto Campos-Gonzalez, Alison Skelley, Khushroo Gandhi, Curt Civin, James C. Sturm, Michael Grisham