Patents by Inventor Michael Grunstein

Michael Grunstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies Against Histone Modifications for Clinical Diagnosis and Prognosis of Cancer
    Publication number: 20080248039
    Abstract: The present invention provides methods of diagnosing and providing a prognosis for a cancer by identifying cancers with altered global histone modification patterns using immunohistochemical techniques.
    Type: Application
    Filed: May 1, 2006
    Publication date: October 9, 2008
    Applicant: The Regents of the University of California
    Inventors: Siavash K. Kurdistani, Michael Grunstein, David B. Seligson
  • Methods for producing ex vivo models for inflammatory disease and uses thereof
    Publication number: 20070275406
    Abstract: The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-?, TNF? or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
    Type: Application
    Filed: July 16, 2007
    Publication date: November 29, 2007
    Inventors: Hakon Hakonarson, Michael Grunstein
  • Methods employing agonists of P38 map kinase for the treatment of asthma
    Publication number: 20050277602
    Abstract: Methods for treating asthma using agonists of p38 are disclosed. Also provided are screening methods to identify test compounds which have efficacy for the treatment of asthma.
    Type: Application
    Filed: May 23, 2005
    Publication date: December 15, 2005
    Inventor: Michael Grunstein
  • Methods for producing Ex vivo models for inflammatory disease and uses thereof
    Publication number: 20050191272
    Abstract: The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-1?, TNF? or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
    Type: Application
    Filed: December 22, 2004
    Publication date: September 1, 2005
    Applicants: deCODE genetics ehf., The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Michael Grunstein
  • Composition and methods for treatment asthma
    Publication number: 20050079175
    Abstract: Methods of treating or preventing induction of asthma in a human patient are provided. The methods comprise administering to the human an anti-Fc?RII receptor protein ligand suspended in a pharmaceutically acceptable carrier in an amount sufficient to inhibit binding of IgE to an anti-Fc?RII receptor protein thereby treating or preventing induction of asthma in the human.
    Type: Application
    Filed: August 21, 2003
    Publication date: April 14, 2005
    Inventors: Michael Grunstein, Hakon Hakonarson