Patents by Inventor Michael Grunze

Michael Grunze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9080146
    Abstract: This disclosure relates to substrates containing at least one polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The disclosure also relates to a method for producing such substrates and substrates containing polyphosphazene with a micro-structured surface.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: July 14, 2015
    Assignee: CELONOVA BIOSCIENCES, INC.
    Inventors: Michael Grunze, Ulf Fritz
  • Patent number: 8313841
    Abstract: The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: November 20, 2012
    Assignee: CeloNova BioSciences Germany GmbH
    Inventors: Andreas Schuessler, Michael Grunze, Roman Denk
  • Publication number: 20120118436
    Abstract: The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.
    Type: Application
    Filed: January 23, 2012
    Publication date: May 17, 2012
    Inventors: Andreas Schüssler, Michael Grunze, Roman Denk
  • Patent number: 8101275
    Abstract: The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: January 24, 2012
    Assignee: Celonova Biosciences, Inc.
    Inventors: Andreas Schüssler, Michael Grunze, Roman Denk
  • Patent number: 8007821
    Abstract: The invention relates to substrates containing polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The invention also relates to a method for producing said substrates and substrates containing polyphosphazene with a microstructured surface.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: August 30, 2011
    Assignee: CeloNova BioSciences Germany GmbH
    Inventor: Michael Grunze
  • Publication number: 20090117637
    Abstract: This disclosure relates to substrates containing at least one polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The disclosure also relates to a method for producing such substrates and substrates containing polyphosphazene with a micro-structured surface.
    Type: Application
    Filed: September 25, 2008
    Publication date: May 7, 2009
    Applicant: CELONOVA BIOSCIENCES, INC.
    Inventors: Michael Grunze, Ulf Fritz
  • Patent number: 7265199
    Abstract: The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing excessive cell proliferation. Furthermore, it relates to films made from the polymer as well as wrappings for medical devices such as stents. It also relates to medical devices that are enclosed by a film or wrapping according to the invention.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: September 4, 2007
    Assignee: Celonova BioSciences Germany GmbH
    Inventors: Michael Grunze, Claudia Gries
  • Publication number: 20070184277
    Abstract: The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.
    Type: Application
    Filed: March 19, 2007
    Publication date: August 9, 2007
    Applicant: CeloNova BioSciences Germany GmbH
    Inventors: Andreas Schussler, Michael Grunze, Roman Denk
  • Publication number: 20040253467
    Abstract: The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.
    Type: Application
    Filed: April 12, 2004
    Publication date: December 16, 2004
    Inventors: Andreas Schssler, Michael Grunze, Roman Denk
  • Patent number: 6764758
    Abstract: The invention relates to a surface-modified layer systems, a method for the production and use thereof. The invention in particular relates to surface-modified layer systems, comprising a substrate and a mono-layer at least partially arranged on said substrate. Said mono-layer is cross-linked in the lateral direction and covalently bonded by anchor groups to at least one surface of said substrate. Said mono-layer is also composed of low molecular weight aromatic and/or heteroaromatic compounds. The mono-layer which is cross-linked in the lateral direction is composed of low molecular weight aromatic and/or heteroaromatic compounds and is integral with the surface-modified layer system, and exhibiting the characteristics of a cross-linked solid. Said mono-layer protects the surfaces of the corresponding substrate from damage caused by friction and corrosion in a particularly advantageous manner.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: July 20, 2004
    Assignee: Universitat Heidelberg
    Inventors: Michael Grunze, Wolfgang Eck, Armin Gölzhäuser, Michel Zharnikov, Volker Stadler, Wolfgang Geyer
  • Publication number: 20040096969
    Abstract: The invention relates to substrates containing polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The invention also relates to a method for producing said substrates and substrates containing polyphosphazene with a microstructured surface.
    Type: Application
    Filed: August 8, 2003
    Publication date: May 20, 2004
    Inventor: Michael Grunze
  • Publication number: 20040014936
    Abstract: The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing excessive cell proliferation. Furthermore, it relates to films made from the polymer as well as wrappings for medical devices such as stents. It also relates to medical devices that are enclosed by a film or wrapping according to the invention.
    Type: Application
    Filed: January 23, 2003
    Publication date: January 22, 2004
    Inventors: Michael Grunze, Claudia Gries
  • Publication number: 20030099683
    Abstract: The present invention relates to polyphosphazene derivatives and their use, having excellent biocompatible properties and imparting bacterial resistance to a coating of an article such as a medical device. In particular, the coating is applied on at least part of a surface of e.g. said medical device and can be used for preventing and/or reducing an inflammatory response upon application of said medical device to a patient.
    Type: Application
    Filed: October 25, 2002
    Publication date: May 29, 2003
    Inventor: Michael Grunze
  • Publication number: 20020054851
    Abstract: The invention concerns a radio-labeled antithrombogenic polymer and its use as part of therapeutic means to prevent excessive cell proliferation or scarring, and means which comprise the radiolabeled antithrombogenic polymer, such as emplastrum or artificial implants with a biocompatible coating.
    Type: Application
    Filed: March 30, 2000
    Publication date: May 9, 2002
    Inventors: Michael Grunze, Alexander Welle
  • Patent number: 5922550
    Abstract: The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of a analyte-specific receptors. Upon attachment of a target analyte to select areas of the plastic film upon which the receptor is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: July 13, 1999
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Dennis S. Everhart, Michael Grunze, Rosann Marie Kaylor, Friderike Karolin Deseree Morhard
  • Patent number: 5288697
    Abstract: Thin protective polyimide layers are produced on ceramic or high temperature superconductors by applying polyimide solutions, polyamic acids or starting substances therefor to the superconductor surface and imidating or drying in an oxygen atmosphere.
    Type: Grant
    Filed: May 6, 1992
    Date of Patent: February 22, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Schrepp, Hans-Joachim Haehnle, Michael Grunze