Abstract: A method for constructing wooden framing for a structure is provided. The method includes locating a base on a horizontal surface, providing a wooden vertical framing support element on the base, installing a horizontal support member between the wooden vertical framing support element and one other wooden vertical framing support element, adjusting at least one of the base and the wooden vertical framing support element to have precise spacing between the wooden vertical framing support element and the one other wooden vertical framing support element, and securing the base to the horizontal surface and the wooden vertical framing support element to the base.

Abstract: A wooden structural joint is provided, including a wooden rectangular base member comprising, at one end, a removed center element, a plurality of removed center edge elements, and four intact corner elements, where the removed center element and the plurality of removed center edge elements are formed from vertical and horizontal cuts into the one end of the wooden rectangular base member, a plurality of horizontal members, each horizontal member having a height and further having a tab cut therein at one edge of the horizontal member, the tab cut at a percentage of the height such that all horizontal members fit securely together when assembled within the wooden rectangular base member, and a wooden rectangular top member having one end cut similar to the wooden rectangular base member.

Abstract: A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containing such compounds may be used to treat neoplasias or to inhibit the growth of certain cancer cells. Screening methods can be employed to identify other compounds for these uses.

Abstract: A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containing such compounds may be used to treat neoplasias or to inhibit the growth of certain cancer cells. Screening methods can be employed to identify other compounds for these uses.

Abstract: The invention provides pskG polypeptides and polynucleotides encoding pskG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pskG polypeptides to screen for antibacterial compounds.

Abstract: The invention provides topA polypeptides and polynucleotides encoding topA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing topA polypeptides to screen for antibacterial compounds.

Abstract: The invention provides mevalonate kinase (hereinafter “MVK”) polypeptides and polynucleotides from Streptococcus pneumoniae encoding mvk polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mvk polypeptides to screen for antibacterial compounds.

Abstract: The invention provides ispA polypeptides and polynucleotides encoding ispA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ispA polypeptides to screen for antibacterial compounds.

Abstract: The invention provides ispA polypeptides and polynucleotides encoding ispA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ispA polypeptides to screen for antibacterial compounds.