Patents by Inventor Michael H Block

Michael H Block has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of compounds for the elevation of pyruvate dehydrogenase activity
    Patent number: 6960688
    Abstract: The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon linked heteroaryl ring substituted as defined within; R1 is an ortho substituent as defined within; n is 1 or 2; A-B is a linking group as defined within; R2 and R3 are as defined within; R4 is hydroxy, hydrogen, halo, amino or methyl; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: November 1, 2005
    Assignee: AstraZeneca AB
    Inventors: Roger J Butlin, Thorsten Nowak, Jeremy N Burrows, Michael H Block
  • Use of compounds for the elevation of pyruvate dehydrogenase activity
    Publication number: 20040009979
    Abstract: The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon linked heteroaryl ring substituted as defined within; R1 is an ortho substituent as defined within; n is 1 or 2; A-B is a linking group as defined within; R2 and R3 are as defined within; R4 is hydroxy, hydrogen, halo, amino or methyl; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.
    Type: Application
    Filed: October 23, 2002
    Publication date: January 15, 2004
    Applicant: ZENECA LIMITED
    Inventors: Roger J. Butlin, Thorsten Nowak, Jeremy N. Burrows, Michael H. Block
  • Use of compounds for the elevation of pyruvate dehydrogenase activity
    Patent number: 6498275
    Abstract: The use of compounds of the formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs: wherein: Ring C is phenyl or a carbon linked heteroaryl ring substituted as defmed within; R1 is an ortho substituent as defined within; n is 1 or 2; A—B is a linking group as defined within; R2 and R3 are as defined within; R4 is hydroxy, hydrogen, halo, amino or methyl; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: December 24, 2002
    Assignee: AstraZeneca AB
    Inventors: Roger J Butlin, Thorsten Nowak, Jeremy N Burrows, Michael H Block
  • Furyl-substituted purines and adenosine antagonists
    Patent number: 5500428
    Abstract: Compounds of formula I, and pharmaceutically acceptable salts thereof, ##STR1## in which R1 is hydrogen (1-6C)alkyl or (1-4C)alkanoyl; A is --N.dbd.CQ--O--, N.dbd.CQ--NR.sup.8 --, --N.dbd.CQ--CH.dbd.N--or --N.dbd.CH--CQ.dbd.N--;Q is 2--furyl;R.sup.8 is hydrogen or C1-4C)alkyl;and R.sup.2 has any of the meanings given in the specification, processes for preparing the compounds and pharmaceutical compositions containing them. The compounds are useful as adenosine antagonists.
    Type: Grant
    Filed: January 13, 1994
    Date of Patent: March 19, 1996
    Assignee: Imperial Chemical Industries PLC
    Inventors: Michael H. Block, Alison Harrison, Rodney B. Hargreaves
  • 2-furyl-oxazolo[5,4-d]-pyrimidines
    Patent number: 5300509
    Abstract: Compounds of formula I, and pharmaceutically acceptable salts thereof, ##STR1## in which R1 is hydrogen (1-6C)alkyl or (1-4C)alkanoyl;A is --N.dbd.CQ--O--, N.dbd.CQ--NR.sup.8 --, --N.dbd.CQ--CH.dbd.N--or --N.dbd.CH--CQ.dbd.N--;Q is 2-furyl;R.sup.8 is hydrogen or C1-4C)alkyl;and R.sup.2 has any of the meanings given in the specification, processes for preparing the compounds and pharmaceutical compositions containing them. The compounds are useful as adenosine antagonists.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: April 5, 1994
    Assignee: Imperial Chemical Industries PLC
    Inventors: Michael H. Block, Alison Harrison, Rodney B. Hargreaves