Patents by Inventor Michael H. LAM

Michael H. LAM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric nanoparticles and methods of making and using same
    Patent number: 10022360
    Abstract: Described herein are polymeric nanoparticles that comprise 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]-triazolo-[3,4-fJ[1,6]-naphthyridin-3-one (Compound A), or a pharmaceutically acceptable salt thereof, and methods of making and using such nanoparticles. The nanoparticle comprises about 50 to about 99.8 weight percent of a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic acid-co-glycolic acid)-poly(ethylene)glycol copolymer, wherein the total amount of poly(ethylene)glycol in the nanoparticle is about 10 to about 30 weight percent poly(ethylene)glycol and about 0.2 to about 30 weight percent of Compound A.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: July 17, 2018
    Assignees: Merck Sharp & Dohme Corp., Pfizer Inc.
    Inventors: Young Ho Song, Greg Troiano, Hong Wang, Maria Figueiredo, Michael H. Lam, Caroline McGregor
  • POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME
    Publication number: 20170087135
    Abstract: Described herein are polymeric nanoparticles that comprise 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]-triazolo-[3,4-fJ[1,6]-naphthyridin-3-one (Compound A), or a pharmaceutically acceptable salt thereof, and methods of making and using such nanoparticles. The nanoparticle comprises about 50 to about 99.8 weight percent of a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic acid-co-glycolic acid)-poly(ethylene)glycol copolymer, wherein the total amount of poly(ethylene)glycol in the nanoparticle is about 10 to about 30 weight percent poly(ethylene)glycol and about 0.2 to about 30 weight percent of Compound A.
    Type: Application
    Filed: March 12, 2015
    Publication date: March 30, 2017
    Applicants: MERCK SHARP & DOHME CORP., BIND THERAPEUTICS, INC.
    Inventors: Young Ho SUNG, Greg TROIANO, Hong WANG, Maria FIGUEIREDO, Michael H. LAM, Caroline MCGREGOR