Patents by Inventor Michael H. Malim

Michael H. Malim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA deamination mediates innate immunity to (retro)viral infection
    Publication number: 20040009951
    Abstract: Provided is a method of establishing an innate cellular immune defense mechanism against infectious (non-cellular) nucleic acid in a vertebrate or in vertebrate cells, comprising deaminating deoxycytidine (dC) to deoxyuridine (dU) in an infecting viral or retroviral nucleic acid in a dose-dependent manner by introducing a cellular nucleic acid deaminase. Also provided are such nucleic acid deaminases and the gene(s) encoding same, and uses therefore including thereapuetic formulations, methods of treatment, assays and methods of mutagenesis. Included are nucleic acid deaminases from the APOBEC family, in which CEM15 (also known as APOBEC3G) is one such nucleic acid deaminase.
    Type: Application
    Filed: June 13, 2003
    Publication date: January 15, 2004
    Inventors: Michael H. Malim, Ann M. Sheehy, Reuben S. Harris, Kate N. Bishop, Michael S. Neuberger, Nathan C. Gaddis, James H.M. Simon
  • Fusion proteins and particles
    Patent number: 5463024
    Abstract: Fusion proteins comprise a first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles; an example is the product of the TYA gene of the yeast retrotransposon Ty. The second amino acid sequence is biologically active; for example it may be antigenic. So particles formed of the fusion proteins may be useful in vaccines or in diagnostic or purification applications.
    Type: Grant
    Filed: September 1, 1993
    Date of Patent: October 31, 1995
    Assignee: British Biotech Pharmaceuticals Limited
    Inventors: Alan J. Kingsman, Susan M. Kingsman, Sally E. Adams, Elizabeth J. C. Mellor, Michael H. Malim
  • Vector expressing fusion proteins and particles
    Patent number: 5041385
    Abstract: Fusion proteins comprising a first amino acid sequence and a second amino acid sequence are disclosed. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles. The TYA gene of the yeast retrotransposon Ty codes for the first amino acid sequence. The second amino acid sequence is a biologically active antigen. The particles formed by the fusion proteins are useful in vaccines or in diagnostic or purification applications.
    Type: Grant
    Filed: April 10, 1987
    Date of Patent: August 20, 1991
    Assignee: Oxford Gene Systems Limited
    Inventors: Alan J. Kingsman, Susan M. Kingsman, Sally E. Adams, Michael H. Malim, Elizabeth-Jane C. Mellor
  • Fusion proteins and particles
    Patent number: 5008373
    Abstract: Fusion proteins comprise a first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability of assemble into particles; an example is the product of the TYA gene of the yeast retrotransposon Ty. The second amino acid sequence is biologically active; for example, it may be antigenic.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: April 16, 1991
    Assignee: Oxford Gene Systems Limited
    Inventors: Alan J. Kingsman, Susan M. Kingsman, Sally E. Adams, Elizabeth J. C. Mellor, Michael H. Malim