Abstract: Provided herein are methods and compositions related to the treatment of sepsis using anti-ANGPTL3 antibodies.

Abstract: A computerized system and method of modeling myocardial tissue perfusion can include acquiring a plurality of original frames of magnetic resonance imaging (MRI) data representing images of a heart of a subject and developing a manually segmented set of ground truth frames from the original frames. Applying training augmentation techniques to a training set of the originals frame of MRI data can prepare the data for training at least one convolutional neural network (CNN). The CNN can segment the training set of frames according to the ground truth frames. Applying the respective input test frames to a trained CNN can allow for segmenting an endocardium layer and an epicardium layer within the respective images of the input test frames. The segmented images can be used in calculating myocardial blood flow into the myocardium from segmented images of the input test frames.

Abstract: A faucet for dispensing beverages includes a valve element that is selectively moved from its seated position to its unseated position by manual linear movement of a handle in a first direction from a retracted position toward an extended position. Movement of the handle in the first direction induces movement of the valve element in the first direction. A shaft projects through the handle and an outer end of the shaft provides a reaction structure or button that is engaged by a thumb of a user during movement of the handle from its retracted position toward its extended position. When in its extended position, the handle can be rotated to a lock-open position where interference between the handle and the faucet body prevents movement of the handle from its extended position to its retracted position whereby the faucet is maintained in an opened condition for continuous dispensing of liquid.

Abstract: A faucet for dispensing liquid with pulp or other suspended solids includes a valve chamber and a valve seat is located in the valve chamber. A valve element for controlling flow of liquid through the valve chamber from the inlet of the body to the outlet of the body includes a valve stem. The valve stem includes (i) a first portion that is closely slidably received in the outlet portion of the liquid flow passage adjacent the valve seat between the valve seat and the outlet; (ii) a second portion connected to the first portion and extending outwardly through the stem aperture of the bonnet such that an outer end of the second portion is located external to the valve chamber; and (iii) a seal located between the first portion and the second portion of the stem. The first portion of the stem cleans the valve seat when the stem moves from the second stem position to the first stem position.

Abstract: A faucet for dispensing beverages includes a valve element that is selectively moved from its seated position to its unseated position by manual linear movement of a handle in a first direction from a retracted position toward an extended position. Movement of the handle in the first direction induces movement of the valve element in the first direction. A shaft projects through the handle and an outer end of the shaft provides a reaction structure or button that is engaged by a thumb of a user during movement of the handle from its retracted position toward its extended position. When in its extended position, the handle can be rotated to a lock-open position where interference between the handle and the faucet body prevents movement of the handle from its extended position to its retracted position whereby the faucet is maintained in an opened condition for continuous dispensing of liquid.

Abstract: A liquid dispensing faucet includes first and second inlet flow passages that are isolated from each other, and first and second valve chambers respectively in fluid communication with the first and second inlet flow passages. First and second valve elements are located respectively in the first and second valve chambers and respectively control flow of liquid from the first and second inlet passages through the first and second valve chambers. First and second outlet passages are respectively in fluid communication with the first and second valve chambers for respectively receiving and dispensing liquid from the first and second valve chambers. A handle is operatively connected to both the first and second valve elements for selectively opening the first and second valve elements to allow flow of liquid through the first and second valve chambers when the handle is moved from a first position to a second position.

Abstract: A faucet for dispensing liquid with pulp or other suspended solids includes a valve chamber and a valve seat is located in the valve chamber. A valve element for controlling flow of liquid through the valve chamber from the inlet of the body to the outlet of the body includes a valve stem. The valve stem includes (i) a first portion that is closely slidably received in the outlet portion of the liquid flow passage adjacent the valve seat between the valve seat and the outlet; (ii) a second portion connected to the first portion and extending outwardly through the stem aperture of the bonnet such that an outer end of the second portion is located external to the valve chamber; and (iii) a seal located between the first portion and the second portion of the stem. The first portion of the stem cleans the valve seat when the stem moves from the second stem position to the first stem position.

Abstract: A faucet handle includes a safety lock. The safety lock includes a latch that is manually movable between an engaged position and a disengaged position. The latch is adapted to engage an associated catch when the latch is in its engaged position. The safety lock also includes a primary lock element that moves between a locked position and an unlocked position. The primary lock element prevents movement of the latch from its engaged position to its disengaged position when the primary lock element is in its locked position. The primary lock element allows movement of the latch from its engaged position to its disengaged position when the primary lock element is in its unlocked position. A faucet including the handle requires three steps to dispense liquid: (i) movement of the primary lock to its unlocked position; (ii) movement of the latch to its disengaged position; and (iii) movement of the handle to its liquid dispensing position.

Abstract: A cup dispenser includes a body defining a storage region adapted for receiving for an associated stack of cup-shaped articles. The body includes an open end that provides access to the storage region. Multiple fingers are connected to the body for restricting the open end of the body. An adjustment ring is connected to the body and is movable relative to the body. Movement of the adjustment ring relative to the body alters a position of each of the fingers relative to the body. The adjustment ring includes a plurality of adjustment slots and the fingers each include an adjustment stud located in one of the adjustment slots. When the adjustment ring is rotated, the adjustment slots act as cams and the adjustment studs act as cam followers such that the fingers are simultaneously and uniformly adjusted in terms of their radial position relative to the body wall.

Abstract: A faucet for controlling the dispensing of liquids includes a valve body having a valve chamber with an inlet and an outlet. A valve element is located in the valve chamber and is movable from a first position for blocking flow between the inlet and outlet to a second position for permitting flow between the inlet and the outlet. An operating stem has an inner end operatively connected to the valve element and an outer end located external to the body. A bonnet is included, and an insert member is rotatably connected to the bonnet and defines an opening through which the stem extends. The bonnet and insert member are secured to the body and enclose the valve element in the valve chamber. The insert is located such that no portion of the insert member is clamped between the bonnet and the body.

Abstract: A liquid dispensing faucet includes first and second inlet flow passages that are isolated from each other, and first and second valve chambers respectively in fluid communication with the first and second inlet flow passages. First and second valve elements are located respectively in the first and second valve chambers and respectively control flow of liquid from the first and second inlet passages through the first and second valve chambers. First and second outlet passages are respectively in fluid communication with the first and second valve chambers for respectively receiving and dispensing liquid from the first and second valve chambers. A handle is operatively connected to both the first and second valve elements for selectively opening the first and second valve elements to allow flow of liquid through the first and second valve chambers when the handle is moved from a first position to a second position.

Abstract: A cup dispenser includes a body defining a storage region adapted for receiving for an associated stack of cup-shaped articles. The body includes an open end that provides access to the storage region. Multiple fingers are connected to the body for restricting the open end of the body. An adjustment ring is connected to the body and is movable relative to the body. Movement of the adjustment ring relative to the body alters a position of each of the fingers relative to the body. The adjustment ring includes a plurality of adjustment slots and the fingers each include an adjustment stud located in one of the adjustment slots. When the adjustment ring is rotated, the adjustment slots act as cams and the adjustment studs act as cam followers such that the fingers are simultaneously and uniformly adjusted in terms of their radial position relative to the body wall.

Abstract: A cup dispenser includes a body defining a storage region adapted for receiving for an associated stack of cup-shaped articles. The body includes an open end that provides access to the storage region. Multiple fingers are connected to the body for restricting the open end of the body. An adjustment ring is connected to the body and is movable relative to the body. Movement of the adjustment ring relative to the body alters a position of each of the fingers relative to the body. The adjustment ring includes a plurality of adjustment slots and the fingers each include an adjustment stud located in one of the adjustment slots. When the adjustment ring is rotated, the adjustment slots act as cams and the adjustment studs act as cam followers such that the fingers are simultaneously and uniformly adjusted in terms of their radial position relative to the body wall.

Abstract: A faucet for controlling the dispensing of liquids includes a valve body having a valve chamber with an inlet and an outlet. A valve element is located in the valve chamber and is movable from a first position for blocking flow between the inlet and outlet to a second position for permitting flow between the inlet and the outlet. An operating stem has an inner end operatively connected to the valve element and an outer end located external to the body. A bonnet is included, and an insert member is rotatably connected to the bonnet and defines an opening through which the stem extends. The bonnet and insert member are secured to the body and enclose the valve element in the valve chamber. The insert is located such that no portion of the insert member is clamped between the bonnet and the body.

Abstract: A faucet handle includes a safety lock. The safety lock includes a latch that is manually movable between an engaged position and a disengaged position. The latch is adapted to engage an associated catch when the latch is in its engaged position. The safety lock also includes a primary lock element that moves between a locked position and an unlocked position. The primary lock element prevents movement of the latch from its engaged position to its disengaged position when the primary lock element is in its locked position. The primary lock element allows movement of the latch from its engaged position to its disengaged position when the primary lock element is in its unlocked position. A faucet including the handle requires three steps to dispense liquid: (i) movement of the primary lock to its unlocked position; (ii) movement of the latch to its disengaged position; and (iii) movement of the handle to its liquid dispensing position.

Abstract: A faucet for controlling the dispensing of liquids including a valve element movable from a first position for blocking flow between an inlet and outlet to a second position for permitting flow between the inlet and the outlet. An insert member is rotatably connected to a bonnet and defines an opening through which a stem extends. The insert member is located with no portion being clamped between the bonnet and a valve body. An actuator handle assembly includes a lever pivotally connected to an end of the stem and a cam actuator connected to the lever. The cam actuator moves between an engaged position in which movement of the lever is effective to move the valve element from its first position to its second position and a disengaged position in which movement of the lever is ineffective to move the valve element from its first position to its second position.

Abstract: A faucet handle includes a safety lock. The safety lock includes a latch that is manually movable between an engaged position and a disengaged position. The latch is adapted to engage an associated catch when the latch is in its engaged position. The safety lock also includes a primary lock element that moves between a locked position and an unlocked position. The primary lock element prevents movement of the latch from its engaged position to its disengaged position when the primary lock element is in its locked position. The primary lock element allows movement of the latch from its engaged position to its disengaged position when the primary lock element is in its unlocked position. A faucet including the handle requires three steps to dispense liquid: (i) movement of the primary lock to its unlocked position; (ii) movement of the latch to its disengaged position; and (iii) movement of the handle to its liquid dispensing position.

Abstract: A cup dispenser includes a body defining a storage region adapted for receiving for an associated stack of cup-shaped articles. The body includes an open end that provides access to the storage region. Multiple fingers are connected to the body for restricting the open end of the body. An adjustment ring is connected to the body and is movable relative to the body. Movement of the adjustment ring relative to the body alters a position of each of the fingers relative to the body. The adjustment ring includes a plurality of adjustment slots and the fingers each include an adjustment stud located in one of the adjustment slots. When the adjustment ring is rotated, the adjustment slots act as cams and the adjustment studs act as cam followers such that the fingers are simultaneously and uniformly adjusted in terms of their radial position relative to the body wall.