Abstract: The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione (“thienouracil”) derivatives having cyclic substituents in the 3 position, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of pulmonary and cardiovascular disorders and of cancer.

Abstract: The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione (“thienouracil”) derivatives bearing a particular type of (azaheterocyclyl)methyl substituent, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of pulmonary and cardiovascular disorders and of cancer.

Abstract: A method and system for safely switching off an electrical load in a system comprising a multi-channel control unit, a single-channel data transmission path and an output unit having a first processing unit, a second processing unit and safe outputs. The method comprises receiving and evaluating an input signal by the multi-channel control unit and generating an enable signal based on the evaluation; transmitting the enable signal to the output unit via the single-channel data transmission path; receiving the enable signal by the first processing unit and generating an output signal based on the enable signal; providing at least one part of the enable signal from the first processing unit to the second processing unit for evaluation therewith; generating a dynamic clock signal by the second processing unit based on the enable signal; and controlling the safe outputs based on the output signal and the dynamic clock signal.

Abstract: The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione (“thienouracil”) derivatives bearing a particular type of (azaheterocyclyl)methyl substituent, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of pulmonary and cardiovascular disorders and of cancer.

Abstract: A compact control device for failsafely controlling an electrical actuator capable of moving a movable machine part into a defined end position, has an input connection for receiving an external control signal representing a desired position of the machine part. The compact control device further has an input part for detecting a position signal, which signals an actual position of the machine part at the defined end position. A power section comprises a power switching element for switching on and failsafely switching off a control current for the actuator that is supplied to the electrical actuator via a first output connection. The compact control device has a second output connection for providing an external status signal and an evaluation unit which actuates the power switching element depending on the external control signal and generates the external status signal at the second output connection depending on the position signal.

Abstract: The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives (“thienouracil”-carboxamides), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for the preparation of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiovascular disorders.

Abstract: The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives (“thienouracil”-carboxamides), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for the preparation of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiovascular disorders.

Abstract: A method and system for safely switching off an electrical load in a system comprising a multi-channel control unit, a single-channel data transmission path and an output unit having a first processing unit, a second processing unit and safe outputs. The method comprises receiving and evaluating an input signal by the multi-channel control unit and generating an enable signal based on the evaluation; transmitting the enable signal to the output unit via the single-channel data transmission path; receiving the enable signal by the first processing unit and generating an output signal based on the enable signal; providing at least one part of the enable signal from the first processing unit to the second processing unit for evaluation therewith; generating a dynamic clock signal by the second processing unit based on the enable signal; and controlling the safe outputs based on the output signal and the dynamic clock signal.

Abstract: The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives (“thienouracil”-carboxamides), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for the preparation of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiovascular disorders.

Abstract: The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumor disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: A bus-based control system comprises a plurality of bus subscribers which are connected to one another by means of a communication medium. The bus subscribers are assigned logical subscriber addresses. Next, the assigned subscriber addresses are verified. For this purpose, the bus subscribers use a defined mathematical operation to calculate a common first check value which is compared with a second check value. The mathematical operation begins with a defined starting value and comprises a number of operation steps which use a number of defined operands. Each of the subscriber addresses to be verified forms a different operand, and each bus subscriber executes at least one operation step.

Abstract: A compact control device for failsafely controlling an electrical actuator capable of moving a movable machine part into a defined end position, has an input connection for receiving an external control signal representing a desired position of the machine part. The compact control device further has an input part for detecting a position signal, which signals an actual position of the machine part at the defined end position. A power section comprises a power switching element for switching on and failsafely switching off a control current for the actuator that is supplied to the electrical actuator via a first output connection. The compact control device has a second output connection for providing an external status signal and an evaluation unit which actuates the power switching element depending on the external control signal and generates the external status signal at the second output connection depending on the position signal.

Abstract: The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumour disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: The present application relates to novel substituted 5-(1,2,4-oxadiazol-5-yl)pyridin-2-ones and 6-(1,2,4-oxadiazol-5-yl)pyridazin-3-ones, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for producing medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.

Abstract: The present application relates to novel aryl compounds with heterocyclic substituents, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.

Abstract: The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: The present application relates to novel 3-(fluorovinyl)pyrazole derivatives, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.

Abstract: The invention relates to aryl-substituted heterocycles, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.