Abstract: The invention relates to methods of treating colorectal cancer in a subject in need thereof. The methods comprising co-administering to the subject: a) a DKK1 antibody, or antigen binding-fragment thereof; b) a VEGF or VEGFR inhibitor; and c) optionally one or more chemotherapeutic agents or a pharmaceutically acceptable salt of any of the foregoing, in an effective amount. The present invention also provides a pharmaceutical composition and a kit comprising a combination of a DKK1 antibody, and a VEGF or VEGFR inhibitor and optionally one or more chemotherapeutic agents.

Abstract: A powershiftable transmission has first, second, and third spur gear stages and first, second, and third shifting elements. A first spur gear is mounted rotatably on an input shaft and can be connected rotationally fixed to the input shaft by the first shifting element. The first spur gear meshes with a second spur gear on an output shaft coupled to a third spur gear. Fourth and fifth spur gears mesh together in the third spur gear stage. The fourth spur gear is on the input shaft and the fifth spur gear is on the output shaft. Actuating the second shifting element couples the input shaft to the output shaft. The third spur gear is rotationally fixed on a second input shaft and the second spur gear is mounted rotatably on the output shaft and can be connected to the output shaft by actuating the third shifting element.

Abstract: Systems and apparatuses include an a system including an engine out sensor, an exhaust sensor, and one or more processing circuits comprising one or more memory devices coupled to one or more processors. The one or more memory devices are configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to receive the engine out sensor information from the engine out sensor, receive the exhaust information from the exhaust sensor, determine the aftertreatment system characteristic based on the exhaust information, compare the aftertreatment system characteristic to an exhaust condition, determine an acceptable input value when the aftertreatment system characteristic meets the exhaust condition, and control at least one of a fuel system actuator and an air handling actuator to achieve the acceptable input value.

Abstract: A system for determining a degree of contamination of production units of a production line for the printing, equipping and reflow soldering of printed circuit boards, and evaluation unit.

Abstract: A method for treating limestone comprising raw meal in a cement clinker plant can be improved by first reacting the raw meal with a carboxylic acid (ROOH), thereby producing at least Ca(RCOO)2, wherein the symbol “R” represents an organic group and subsequently converting the such obtained Ca(ROO)2 into calcined raw meal by thermally decomposing the produced Ca(RCOO)2 and/or Ca(RSO2O)2 to thereby obtain at least CaO, CO2 and RCOH and/or RCOR.

Abstract: CO2 is produced in a cement clinker line by (i) converting a CaCO3 comprising raw meal into calcined raw meal and at least CO2 and/or sintering calcined raw meal in a kiln, there-by obtaining at least cement clinker and optionally CO2. The CO2 emission of the cement clinker line can be significantly reduced by, dissolving at least a portion of the CO2 in a first carboxylic acid and/or a first sulfonic acid and reducing the dissolved CO2 electrolytically at a cathode of an electrolytic cell to a second carboxylic acid and/or a second sulfonic acid, wherein the first carboxylic acid and/or first sulfonic acid is used as a protonic aqueous electrolyte.

Abstract: Representative embodiments of the present technology include a bat having a barrel shell and a frame structure. The barrel shell may include a barrel region of the bat and part of a tapered region of the bat. The frame structure may include a first portion positioned outside the barrel shell and a second portion positioned inside the barrel shell. In some embodiments, a distal end of the frame structure is in the barrel region but is longitudinally spaced from a distal end of the barrel shell. In some embodiments, the distal end of the frame structure is longitudinally spaced from an end cap of the bat. The barrel shell may flex or pivot relative to the second portion of the frame structure. In some embodiments, the only connection between the frame structure and the barrel shell within the barrel shell may be within the tapered region.

Abstract: A method of calibrating a control system based on a parametric value of a component. The method includes receiving a current from a component of the control system. The component is communicatively coupled to a controller and has a parametric resistor with a parametric resistance value correlating to a parametric value associated with the component. The method further includes determining the resistance value of the parametric resistor by measuring a parametric voltage rating from the current. The method further includes mapping the resistance value to the parametric value associated with the component. The method further includes generating a calibration data set. The calibration data set is based on calibrating the control system to calibrate for the parametric value. The method further includes transmitting a signal to the component. The signal is based on the calibration data set and is configured to calibrate operation of the component.

Abstract: A system is configured to store a relationship data set of a plurality of diagnostic estimators and a plurality of failure modes, each failure mode represents a type of failure that can occur with a sensor or a vehicle component of a vehicle system, each diagnostic estimator is associated with a respective subset of the failure modes, each subset defines a control space within the vehicle system that contains at least one of (i) one or more sensors or (ii) one or more vehicle components. The system is configured to store a healthy diagnostic vector regarding nominal operational parameters of the vehicle system; acquire diagnostic information regarding current operational parameters of the vehicle system to generate an error diagnostic vector; apply the error diagnostic vector to the healthy diagnostic vector to generate a ratio diagnostic vector; and apply the ratio diagnostic vector to generate a value for each failure mode.

Abstract: Representative embodiments of the present technology include a bat having a barrel shell and a frame structure. The barrel shell may include a barrel region of the bat and part of a tapered region of the bat. The frame structure may include a first portion positioned outside the barrel shell and a second portion positioned inside the barrel shell. In some embodiments, a distal end of the frame structure is in the barrel region but is longitudinally spaced from a distal end of the barrel shell. In some embodiments, the distal end of the frame structure is longitudinally spaced from an end cap of the bat. The barrel shell may flex or pivot relative to the second portion of the frame structure. In some embodiments, the only connection between the frame structure and the barrel shell within the barrel shell may be within the tapered region.

Abstract: A system includes an aftertreatment system and a controller coupled to the aftertreatment system. The controller is configured to generate a spatially resolved model of a catalyst of the aftertreatment system. The controller is further configured to adjust the spatially resolved model based on one or more sensed values from at least one sensor upstream of the one or more portions and at least one sensor downstream of the one or more portions.

Abstract: A system can include one or more processors coupled with memory in communication with a vehicle system comprising a plurality of field-replaceable units (FRUs). The one or more processors can be configured to: generate, for each FRU of the plurality of FRUs of the vehicle system, a computer-based simulation; determine a degradation level for each FRU of the plurality of FRUs based on the computer-based simulation and operating data of each FRU of the plurality of FRUs; identify, from the plurality of FRUs, an FRU corresponding to a failure in the vehicle system based on the degradation level for the FRU; and provide an electronic notification identifying the failure in the vehicle system as corresponding to the FRU.

Abstract: A system is configured to store a relationship data set of a plurality of diagnostic estimators and a plurality of failure modes, each failure mode represents a type of failure that can occur with a sensor or a vehicle component of a vehicle system, each diagnostic estimator is associated with a respective subset of the failure modes, each subset defines a control space within the vehicle system that contains at least one of (i) one or more sensors or (ii) one or more vehicle components. The system is configured to store a healthy diagnostic vector regarding nominal operational parameters of the vehicle system; acquire diagnostic information regarding current operational parameters of the vehicle system to generate an error diagnostic vector; apply the error diagnostic vector to the healthy diagnostic vector to generate a ratio diagnostic vector; and apply the ratio diagnostic vector to generate a value for each failure mode.

Abstract: A computing system is structured to receive operating data provided by a telematics circuit associated with a remote engine. The operating data comprises information provided by at least one sensor and/or at least one actuation command. The computing system is structured to determine, based on the operating data, a plurality of field-replaceable units (FRUs) associated with the operating data. The computing system is structured to generate a computer-based simulation corresponding to at least one degradation level for an FRU from the plurality of FRUs, identify a most probable failure, and rank the computer-based simulations across the plurality of FRUs. The computing system is structured to generate an electronic notification comprising data associated with the most probable failure and transmit the electronic notification to a computing device.

Abstract: A controller to diagnose a selective catalytic reduction (SCR) system of an aftertreatment system executes computer-readable instructions to determine a first NOx value at an outlet of the SCR system, determine an ammonia (NH3) slip value based at least in part on the first NOx value, determine a second NOx value of a healthy SCR model, determine a third NOx value of a degraded SCR model, compute at least one degradation factor based on the ammonia slip, the first NOx value, the second NOx value, and the third NOx value, and diagnose a normal operation or an abnormal operation of the SCR system based on the at least one degradation factor.

Abstract: A method of manufacturing a core for a production process and to a core manufactured in accordance with the method are provided. The method includes providing a mold containing a soluble substance and one or more fibers and causing the soluble substance to solidify around the one or more fibers.

Abstract: The invention relates to a conveyor belt for transporting food products having a packaging composed of a magnetizable material, in particular cans, along a transport direction, wherein the conveyor belt comprises a belt body and a transport belt that runs around the belt body in the operation of the conveyor belt and that has an upper run and a lower run. The belt body is provided with a magnet arrangement that generates a magnetic field that acts in the direction of the upper run of the transport belt and that has a higher value at the belt entry side than at the belt exit side.

Abstract: A system for determining a degree of contamination of production units of a production line for the printing, equipping and reflow soldering of printed circuit boards, and evaluation unit.

Abstract: An agricultural machine transmission has a powershiftable main group arranged upstream or downstream of a powershiftable split group in the direction of force transfer. The split group has an input shaft, an output shaft, and powershift elements, which when selectively actuated permit configurations of at least six different forward gears and at least three different reverse gears between the input shaft and the output shaft of the split group. A driveshaft of the main group is connectable by a first powershift clutch to a first input shaft and is connectable by a second powershift clutch to a second input shaft of the main group. Spur gear stages of the main group can be integrated into the force transfer path by actuating an associated shift element, coupling an associated input shaft to the drive shaft of the main group by configuring a respective gear of the main group.

Abstract: The present disclosure relates to a method for detecting a defect (16) in a pipeline wall (14) and a pipeline inspection device for being inserted into a pipeline. The method comprises the steps of arranging a first ultrasonic transducer (10) inside a pipeline at a finite stand-off distance (d-i) from the pipeline wall (14); emitting, by the first ultrasonic transducer (10), a first ultrasonic signal towards the pipeline wall (14) at a finite angle (a) relative to a normal of the pipeline wall (14), wherein the first ultrasonic signal excites at least one fundamental Lamb mode in the pipeline wall (14); and receiving, by the first ultrasonic transducer (10), a second ultrasonic signal from the surface of the pipeline wall (14), wherein the second ultrasonic signal is an echo signal generated by the at least one fundamental Lamb mode excited by the first ultrasonic signal and reflected from a defect (16) in the pipeline wall (14).