Abstract: Disclosed are p53 modulators represented by the following structural formula I: The variables in structural formula I are described herein. Also disclosed are method of treating cancer in a subject with the disclosed p53 modulators, particularly cancers with dysfunctional p53.

Abstract: The present disclosure provides methods for assessing mucosal healing in a patient with Crohn's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

Abstract: An assay method for detecting the presence or amounts of VCAM-1 and A2M in a sample using fluorescence resonance energy transfer (FRET).

Abstract: An assay method for detecting the presence or amounts of VCAM-1 and A2M in a sample using fluorescence resonance energy transfer (FRET).

Abstract: Rule-based modeling for building control systems is described herein. One device includes a memory, a user, interface, and a processor configured to execute executable instructions stored in the memory to display, in a single view on the user interface, a listing of all components of a facility controlled by a building control system, display, in an additional view on the user interface, a number of rules for mapping the components of the facility to a common model of the building control system, map the components of the facility to the common model by applying the number of rules to the components of the facility, and display, in the additional view on the user interface, the components of the facility that have been mapped to the common model.

Abstract: The present disclosure provides methods for assessing mucosal healing in a patient with Crohn's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: An assay method for detecting the presence or amounts of VCAM-1 and A2M in a sample using fluorescence resonance energy transfer (FRET).

Abstract: The present disclosure provides solution based assays for detecting antibodies induced by SARS-CoV-2 (anti-SARS-CoV-2) in a biological sample.

Abstract: Methods and compositions are disclosed for preparing a predetermined standardized calibration curve, which can be stored on a label, barcode or tag. A lyophilized product containing assay reagents for use in a bioassay and a known amount of analyte. A predetermined calibration curve associated with the lyophilized product. A predetermined calibration curve makes the preparation of a new calibration curve unnecessary. The methods and compositions are useful in bioassays such as a FRET assay, a real-time reverse transcription polymerase (RT-PCR) assay, a chemiluminescence assay, or any other bioassay that elicits a detectable response based on a change in, or appearance of, color, fluorescence, or reflectance.

Abstract: A lamp platform assembly for emitting at least one light beam in various patterns, directions or orientations may include multi-positional support platform. At least one lamp unit may be carried by the support platform. Each lamp unit may be selectively positional to direct an emitted light beam in a selected direction or orientation. At least one electrical system may electrically interface with the at least one lamp unit. The at least one electrical system may be configured to provide electrical power to the at least one lamp unit.

Abstract: A cane includes an integral light in the handle, a leg attachment strap, and a foot attaching stirrup. The cane includes a rod assembly and a stirrup assembly. In one embodiment, the rod assembly includes a rod being a uniform cylindrical structure that is adapted to extend the length of a user's leg. The handle is disposed at a top most end of the rod and includes the light being embedded therein to provide illumination to the front and rear of a user. The stirrup provides a means for a user to nestle their foot to provide proper support.

Abstract: The present disclosure provides assay methods to detect and measure proteins in order to distinguish between a bacterial infection and a viral infection.

Abstract: Rule-based modeling for building control systems is described herein. One device includes a memory, a user, interface, and a processor configured to execute executable instructions stored in the memory to display, in a single view on the user interface, a listing of all components of a facility controlled by a building control system, display, in an additional view on the user interface, a number of rules for mapping the components of the facility to a common model of the building control system, map the components of the facility to the common model by applying the number of rules to the components of the facility, and display, in the additional view on the user interface, the components of the facility that have been mapped to the common model.

Abstract: Rule-based modeling for building control systems is described herein. One device includes a memory, a user, interface, and a processor configured to execute executable instructions stored in the memory to display, in a single view on the user interface, a listing of all components of a facility controlled by a building control system, display, in an additional view on the user interface, a number of rules for mapping the components of the facility to a common model of the building control system, map the components of the facility to the common model by applying the number of rules to the components of the facility, and display, in the additional view on the user interface, the components of the facility that have been mapped to the common model.

Abstract: Provided herein are methods for accommodating for sample matrix effects in light measurement assays. A selected amount of a light emitting material is added to a sample, and the light output from the sample is measured. By using an algorithm based on the known light emitting material amount and the measured light output, a correction factor for the assay of the sample is determined. The correction factor can be used to adjust subsequent light output measurements of other samples recorded using the assay.

Abstract: An assay method for detecting the presence or amount of human serum albumin vitamin D, C-reactive protein, or anti-transglutaminase autoantibody (ATA) immunoglobulin A (IgA) and/or ATA IgG in a sample using fluorescence resonance energy transfer (FRET).

Abstract: An assay method for detecting and measuring the presence or amount of glycated hemoglobin in a sample using fluorescence resonance energy transfer (FRET).

Abstract: The present disclosure provides methods for assessing mucosal healing in a patient with Crohn's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.