Abstract: The present invention is related to a structural protein of a parvovirus with an amino acid insertion at the insertion site I-453, a library comprising the protein, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a vector, virus or cell comprising the nucleic acid, a process for the preparation of the protein, a medicament comprising the protein, nucleic acid or multimeric structure as well as methods and uses involving the protein, nucleic acid or multimeric structure.

Abstract: The invention relates to a method for detecting at least one object (9a, 9b, 9c) in a surrounding area (7) of a motor vehicle (1) by means of a driver assistance system (2), in which a transmission signal is transmitted in each of chronologically consecutive measurement cycles via a distance sensor (4), and a first and a second echo of the transmission signal reflected by the at least one object (9a, 9b, 9c) are received; and, by means of a control device (3), a first distance value (a1) is determined based on the first echo, a second distance value (a2) is determined based on the second echo, and a height of the at least one object (9a, 9b, 9c) is determined based on the first and the second distance value (a1, a2); wherein the measurement cycles are carried out during a relative movement of the motor vehicle (1) with respect to the at least one object (9a, 9b, 9c); in at least two of the measurement cycles, a difference value is determined in each case, which describes a difference between the second distan

Abstract: The invention relates to a method for operating a motor vehicle, in which by at least one ultrasonic sensor, operated in the active operation mode, of an ultrasonic sensor device of the motor vehicle ultrasonic waves are emitted into an environmental region of the motor vehicle, wherein the motor vehicle as hybrid vehicle is equipped with an internal combustion engine (and an electric drive machine and in the active operation mode of the ultrasonic sensor arranged on a rear part of the motor vehicle the motor vehicle at least temporarily is operated by means of the electric drive machine. The invention also relates to a motor vehicle.

Abstract: The invention relates to a method for operating at least one ultrasonic sensor (4, 6) of a driver assistance system (2) in a motor vehicle (1), wherein an output sound signal (SA) of the ultrasonic sensor (4, 6) is modulated in accordance with a type of modulation and by means of this modulation, a specific codeword is impressed on the output sound signal (SA). For at least two mutually different functionalities (8 to 12) of the driver assistance system (2), different types of modulation are in each case used for the modulation of the output sound signal (SA) and/or in each case different lengths of the codeword.

Abstract: The present invention is related to a structural protein of a parvovirus with an amino acid insertion at the insertion site I-453, a library comprising the protein, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a vector, virus, or cell comprising the nucleic acid, a process for the preparation of the protein, a medicament comprising the protein, nucleic acid, or multimeric structure as well as methods and uses involving the protein, nucleic acid, or multimeric structure.

Abstract: The invention relates to a method for operating an ultrasonic sensor apparatus (2) of a motor vehicle (1), in which method ultrasound waves are emitted into a surrounding region (9) of the motor vehicle (1) by at least one ultrasonic sensor (3) of the ultrasonic sensor apparatus (2) in order to carry out a distance measurement, wherein an exhaust gas cloud (22) which is emitted into the surrounding region (9) by an exhaust system (11) of the motor vehicle (1) and at which the ultrasound waves are reflected is detected by the ultrasonic sensor apparatus (2) on the basis of sensor data from at least one sensor (18, 19, 20, 21) of the motor vehicle (1), which at least one sensor is different from the ultrasonic sensor (3), and the ultrasonic sensor apparatus (2) is operated depending on the detection of the exhaust gas cloud (22).

Abstract: The invention relates to a method for detecting a blocked state of an ultrasonic sensor (3) of a motor vehicle (1), in which at least one oscillation parameter of the ultrasonic sensor (3) is recorded and an evaluation device (4) of the motor vehicle (1) carries out a detection algorithm which is used to evaluate the at least one oscillation parameter for the purpose of detecting the blocked state. An object (9) in an area surrounding the motor vehicle (1) is detected by the evaluation device (4) on the basis of sensor data from at least one sensor (3, 8) of the motor vehicle (1), in which case, when a distance (D) between the object (9) and the ultrasonic sensor (3) falls below a predefined threshold value (G), the detection algorithm is not carried out by the evaluation device (4) or a blocked state of the ultrasonic sensor (3), as detected using the detection algorithm, is ignored by the evaluation device (4).

Abstract: The invention relates to a method for detecting target echoes (11) in a reception signal (ES) of an ultrasonic sensor of a motor vehicle by providing a reference signal (RS) for decoding the reception signal (ES), wherein with respect to a multiplicity of predetermined frequency shift values in each case a correlation input signal (RS) is provided by shifting the reference signal (RS) in terms of its frequency by the respective frequency shift value; correlating the reception signal (ES) separately with each of the correlation input signals (RS) and thereby providing respective correlation output signals (KS1 to KS7), as the result of the respective correlation; and by providing a summation signal (SS) as the sum of the correlation output signals (KS1 to KS7), wherein on the basis of the summation signal (SS) one of the correlation output signals (KS1 to KS7) is selected and detecting the target echoes (11) is carried out by evaluating the selected correlation output signal (KS1 to KS7).

Abstract: The invention relates to a driver assistance device (2) having a plurality of ultrasound sensors, wherein at least one first ultrasound sensor (8 to 11, 17, 18, 21 to 24) has a normal mode as an operating mode in which transmitted ultrasound signals are unencoded and/or in which the first ultrasound sensor (8 to 11, 17, 18, 21 to 24) is designed for receiving unencoded ultrasound signals, and at least one second ultrasound sensor (6, 7, 13 to 16, 19, 20) can be operated in two different operating modes and has the normal mode as a first operating mode and has a special mode as a second operating mode, in which transmitted ultrasound signals are encoded and/or in which the second ultrasound sensor (6, 7, 13 to 16, 19, 20) is designed for receiving encoded ultrasound signals. The invention also relates to a vehicle (1) having a driver assistance device (2) and a method for operating a driver assistance device (2).

Abstract: The invention relates to an ultrasonic sensor device for a motor vehicle, comprising a membrane (11) for transmitting and receiving ultrasonic waves, comprising an excitation element (12) designed for providing an electrical reception signal upon reception of the ultrasonic waves and also for exciting the membrane (11) for transmitting the ultrasonic waves, comprising a transmitter (13) for emitting electrical pulses to the excitation element (12) and comprising a receiver (16) for receiving and conditioning the electrical reception signal, wherein the ultrasonic sensor device (2) comprises a diagnosis unit (22), which is designed to carry out a diagnosis of the receiver (16) and in the process to check the receiver (16) with regard to its functionality.

Abstract: The invention relates to a method for determining the signal-to-noise ratio (20) of a target echo (11) from a received signal (UE) received from an ultrasonic sensor (3) of a motor vehicle (1), in which: a transmission signal is transmitted in encoded form, the received signal (UE) is decoded and decoding involves the received signal (UE) being correlated with a reference signal and the correlation provides a correlation signal (UK), and the target echo (11) is detected in the correlation signal (UK), wherein the signal-to-noise ratio (20) is determined by determining a value (21) of the noise in the received signal (UE) on the basis of the correlation signal (UK) and, in so doing, dividing the correlation signal (UK) into a multiplicity of signal segments (17a to 17e) and determining the value (21) of the noise solely on the basis of signal values for that one of the signal segments (17a to 17e) that contains the target echo (11).

Abstract: The invention relates to an ultrasonic sensor arrangement (8) for a motor vehicle (14), with a panel part (9) of the motor vehicle (14) and an ultrasonic sensor (2) which has a front side (3) and is designed for transmitting and/or receiving ultrasonic signals via the front side (3), wherein the ultrasonic sensor (2) is arranged within a continuous recess (10) in the panel part (9) and the recess (10) is covered by a covering (11) which does not impair the transmission and/or reception of the ultrasonic signals, wherein the panel part (9) has a material (M) and/or a material thickness (d2), by means of which the transmission and/or the reception of the ultrasonic signals is blocked at least in a region of the panel part (9) surrounding the recess (10). The invention also relates to a motor vehicle (14) and to a method for installing an ultrasonic sensor (2) in a panel part (9) of a motor vehicle (14).

Abstract: The invention relates to a method for detecting a blocked state of an ultrasonic sensor (3) of a motor vehicle (1), wherein an actual value of at least one oscillation parameter (fR) of the ultrasonic sensor (3) is sensed and is compared with a reference value by means of an evaluation unit (4) in order to detect a blocked state, wherein a current temperature (T) to which the ultrasonic sensor (3) is exposed is detected by means of a temperature detecting device (8), and the reference value is determined as a function of the current temperature (T) by means of the evaluation unit (4).

Abstract: The present invention is related to a method for identifying a parvovirus mutated structural protein capable of specifically binding to a binder for an antigen, a parvovirus mutated structural protein which comprises at least one B-cell epitope heterologous to the parvovirus, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a virus or cell comprising the protein, a method of preparing the protein, a medicament comprising the protein, nucleic acid or multimeric structure and its use.

Abstract: The invention relates to a driver assistance device (2) having a plurality of ultrasound sensors, wherein at least one first ultrasound sensor (8 to 11, 17, 18, 21 to 24) has a normal mode as an operating mode in which transmitted ultrasound signals are unencoded and/or in which the first ultrasound sensor (8 to 11, 17, 18, 21 to 24) is designed for receiving unencoded ultrasound signals, and at least one second ultrasound sensor (6, 7, 13 to 16, 19, 20) can be operated in two different operating modes and has the normal mode as a first operating mode and has a special mode as a second operating mode, in which transmitted ultrasound signals are encoded and/or in which the second ultrasound sensor (6, 7, 13 to 16, 19, 20) is designed for receiving encoded ultrasound signals. The invention also relates to a vehicle (1) having a driver assistance device (2) and a method for operating a driver assistance device (2).

Abstract: The present invention is related to a method for identifying a parvovirus mutated structural protein capable of specifically binding to a binder for an antigen, a parvovirus mutated structural protein which comprises at least one B-cell epitope heterologous to the parvovirus, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a virus or cell comprising the protein, a method of preparing the protein, a medicament comprising the protein, nucleic acid or multimeric structure and its use.

Abstract: The invention relates to a method for operating at least one ultrasonic sensor (4, 6) of a driver assistance system (2) in a motor vehicle (1), wherein an output sound signal (SA) of the ultrasonic sensor (4, 6) is modulated in accordance with a type of modulation and by means of this modulation, a specific codeword is impressed on the output sound signal (SA). For at least two mutually different functionalities (8 to 12) of the driver assistance system (2), different types of modulation are in each case used for the modulation of the output sound signal (SA) and/or in each case different lengths of the codeword.

Abstract: The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.

Abstract: The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.

Abstract: The present invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one modification which brings about a reduction in the antigenicity, its production and use.