Abstract: The present disclosure generally relates to fluorescent light energy system and to methods of using such systems in the modulation of inflammatory response, in particular in inflammatory response associated with healing, and for modulation of a treatment regimen for promoting healing of a wound or a condition of the skin and/or soft tissue.

Abstract: A method is provided for controlling a device configured for treating a disorder of a subject. The method comprises providing power to an implantable device configured to be located within a submucosa of a nasal cavity of the subject to cause the implantable device to emit near-infrared light and red light directed to at least one of regions of an ocular structure, regions of a cerebrum, cerebral nerves, and cerebrospinal fluid, regions of a vascular system, and regions of a lymphatic system of the subject. The device is configured to be implanted in a position to deliver the near-infrared light and the red light to the at least one of the regions of the ocular structure, the regions of the cerebrum, cerebral nerves, and cerebrospinal fluid, regions of the vascular system, and the regions of the lymphatic system in a dosimetry and duration sufficient to treat the disorder.

Abstract: Compositions and methods for the use of photoactivatable antimicrobial chalcogen analogs of benzophenoxazinium dyes in the treatment of infections are provided.

Abstract: The present invention relates to devices for detection and therapy of active atheromatous plaque and/or thin-capped fibro-atheroma (“vulnerable plaque”), using selectively targeted fluorescent, radiolabeled, or fluorescent and radiolabeled compositions. The present invention further relates to methods and devices for detection and therapy of active atheromatous plaques and/or vulnerable plaques, using selectively targeted beta-emitting compositions, optionally comprising fluorescent compositions.

Abstract: The present invention relates the use photosensitizers to inactivate bacterial spores of bacterial species including Bacillus anthracis. Methods of the present invention are useful in the decontamination and treatment of living animals and in the decontamination of inanimate objects and substances.

Abstract: The present invention relates to methods for selectively targeting Photodynamic Therapy (“PDT”) to inflammatory components of vulnerable plaques. As such, the present invention provides methods for the identification of vulnerable plaques, using fluorescent compositions, which include photosensitizer compoisitions, and/or radiolabeled compounds, as well as methods to treat vulnerable plaques by selectively targeting and/or eliminating the inflammatory components of vulnerable plaques.