Abstract: Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Provided herein are automated apparatus for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by sequencing.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

Abstract: Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

Abstract: Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

Abstract: Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

Abstract: A system, method and apparatus for network security monitoring, information sharing and collective intelligence between and among at least a first central processing unit and at least a second central processing unit connected together by a network. The system includes a network interface device with hardware-based logic for recognizing and cataloging individual sessions, wherein the network interface card is in communication with the network. The network interface device includes onboard cryptographic key management components with symmetric key algorithms, an onboard packet encryption software module using derived keys to encrypt network packets, and software for storing encrypted copies of network packets as blocks. Third party analyst hardware and software derive keys necessary to retrieve encrypted network packets.

Abstract: A method and apparatus for waveguide-based and free space based optical interconnection in integrated circuits that includes an input optical waveguide with etched end-facets, an output optical waveguide with an end-facets and modulators and detectors.

Abstract: A method and apparatus for achieving high-density and misalignment tolerant short-reach free-space optical interconnects between arbitrary locations in a field, using microlenses, steering elements and a curved reflecting surface.

Abstract: A ceiling tile dust guard is provided wherein the dust guard includes in combination a room having wall and the wall comprising a ceilimg, a ventilation duct vent, and rails in the ceiling. The duct vent defines a plane parallel to the ceiling and provides a direction of air flow out of the vent into the room; the dust guard adjacent the duct vent provides a peripheral wall substantially perpendicular to and projecting away from the duct vent into the room diverting air flowing through the vent away from the ceiling adjacent the vent so that static electricity doesn't attract particles in the air flow onto the ceiling. The duct vent comprises a vent housing and the supporting means comprises rails in the ceiling supporting the vent housing.