Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

Abstract: Coated shaped articles contain at least one shaped article with foamed beads containing at least one polyurethane (A) and at least one coating containing at least one polyurethane (B), wherein polyurethane (A) and polyurethane (B) are each constructed from at least one polyol and at least one polyisocyanate and wherein not less than 50 wt % of the polyol component used for constructing polyurethane (A) and polyurethane (B) is identical and not less than 50 wt % of the at least one polyisocyanate component used for constructing polyurethane (A) and polyurethane (B) is identical. Processes for producing the coated shaped articles and the method of using the coated shaped articles for various applications can be utilized.

Abstract: The present disclosure relates to a cap for an injection device. The injection device comprises a body for holding a syringe having a needle extending from an end thereof. The cap is removably attachable to the body. The cap comprises an actuator and a needle shield to cover said needle. The cap further comprises a coupling between the actuator and the needle shield. The coupling is configured such that when the cap is attached to the body of the injection device axial movement of the actuator away from the body causes rotation of the needle shield relative to the body.

Abstract: An auto-injector device comprises a stopper for expelling a medicament out of a medicament reservoir; a driving element which has a first configuration and a second configuration and is configured to change shape from the first configuration to the second configuration when the temperature of the driving element is raised above a shape change temperature, so as to drive the stopper of the syringe mechanism through the medicament reservoir; and a heating mechanism configured to actively heat the driving element. The heating mechanism is a chemical heating element configured to generate heat through an exothermic process or comprises a fluid reservoir for retaining a fluid; a heater configured to heat the fluid in the fluid reservoir; a pump configured to expel the fluid out of the fluid reservoir; and a connecting conduit arranged to carry the fluid from the fluid reservoir to the driving element.

Abstract: A composite material contains a nonwoven layer (i) which contains fibers formed from a first thermoplastic elastomer having meshes with a mesh size in the range from 10 to 100 ?m, and a membrane layer (ii) which contains a second thermoplastic elastomer and having a layer thickness of less than 30 ?m. The membrane is either pore-free (ii.1) or is porous and has pores with an average pore diameter of less than 2000 nm (ii.2). The membrane (ii) is at least partially in direct contact with the fibers of the nonwoven layer (i) and covers the mesh openings in the nonwoven layer (i) at least partially. The fibers of the first nonwoven layer (i) and the membrane (ii) in the contact area are at least partly joined to one another in an interlocking manner.

Abstract: A system for supporting on the use of an injection device includes a display and a processor configured to determine the injection device, to obtain data on use of the determined injection device and to add at least one overlay on the display, wherein the at least one overlay is generated depending on the obtained data on use of the determined injection device. The processor is configured to adapt the at least one overlay depending on a context of application of the injection device, the context of application of the injection device including at least one of the following: ambient light; time; date; temperature; use history of the injection device; drug; injection site; dosage.

Abstract: A medication delivery device and/or dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having a dose setting system and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge.

Abstract: A system for supporting on the use of an injection device includes a display and a processor configured to determine the injection device, to obtain data on use of the determined injection device and to add at least one overlay on the display, wherein the at least one overlay is generated depending on the obtained data on use of the determined injection device. The processor is configured to adapt the at least one overlay depending on a context of application of the injection device, the context of application of the injection device including at least one of the following: ambient light; time; date; temperature; use history of the injection device; drug; injection site; dosage.

Abstract: A supporting wing structure for an aircraft, in particular for a load-carrying and/or passenger-carrying aircraft, preferably an aircraft in the form of a vertical take-off and landing multicopter having a plurality of electrically driven rotors which are disposed in a distributed manner. The supporting wing structure has a plurality of struts. A first number of the struts are at least largely disposed in a first direction, while a second number of the struts are at least largely disposed in a second direction, the second direction being oriented orthogonal to the first direction. At least the struts of the second number have an aerodynamic profile in cross section, and/or in the struts are connected to one another at least in pairs between neighboring struts by a connecting structure, preferably from individual connecting segments, and the connecting structure or the connecting segments have an aerodynamic profiling. Furthermore an aircraft is provided equipped with such a supporting wing structure.

Abstract: A composite material contains a nonwoven layer (i) which contains fibers formed from a first thermoplastic elastomer having meshes with a mesh size in the range from 10 to 100 ?m, and a membrane layer (ii) which contains a second thermoplastic elastomer and having a layer thickness of less than 30 ?m. The membrane is either pore-free (ii.1) or is porous and has pores with an average pore diameter of less than 2000 nm (ii.2). The membrane (ii) is at least partially in direct contact with the fibers of the nonwoven layer (i) and covers the mesh openings in the nonwoven layer (i) at least partially. The fibers of the first nonwoven layer (i) and the membrane (ii) in the contact area are at least partly joined to one another in an interlocking manner.

Abstract: An aircraft with folding mechanism, the aircraft including a fuselage, optionally a payload and/or landing gear attached to the fuselage, at least two longitudinal beams attached to the fuselage that preferably extend parallel to each other and parallel to a first aircraft axis, with lifting units attached to each of the longitudinal beams. At least one crossbeam is attached to the fuselage, and preferably extending parallel to a second aircraft axis and at right angles with respect to the longitudinal beams, with lifting units attached to the crossbeam. The longitudinal beams are rotatably attached to the fuselage by at least one respective first pivot joint configured for pivoting the longitudinal beams around a respective first pivot axis to a pivoted position. The crossbeam is rotatably attached to the fuselage, preferably by at least one second pivot joint, for pivoting the crossbeam around a second pivot axis to a pivoted position.

Abstract: The present disclosure relates to an injection device. The injection device comprises a body for holding a syringe having a needle extending from one end thereof and a cap that is removably attached to the body. The cap has a needle shield to cover said needle. The injection device further comprises a biasing member and a lock. The biasing member is configured to urge at least a part of the cap away from the body. The lock is moveable between a locked state, wherein the lock holds the cap and body together, and an unlocked state, wherein the cap and body are able to move apart.

Abstract: An injection device comprising: a housing arranged to contain a syringe with a piston for sealing the syringe and displacing the medicament, the housing having a proximal end and a distal end, wherein the distal end is intended to be applied against an injection site; a driving mechanism arranged between the piston and the proximal end of the housing; and a locking mechanism comprising a plate member arranged between the driving mechanism and the piston to retain the driving mechanism to retain the driving mechanism in an initial inactive state in which the driving mechanism cannot be actuated; wherein when the locking mechanism is released, the driving mechanism can be actuated to push the piston towards the distal end of the housing to displace the medicament.

Abstract: The present disclosure relates to a drug delivery device that has a housing and a cap. The drug delivery device also has a lock that prevents the cap being fully replaced on the housing after the cap has been removed.

Abstract: A method for changing the shape of a sheet-like workpiece, which has a mould recess formed by reducing the thickness of the material, includes arranging the workpiece on at least two spaced-apart supporting elements of a machine bed, and forming the workpiece into a final shape by step-by-step free bending. The steps of bending a part of the workpiece by lowering an upper die between the supporting elements from a waiting position into a forming position, raising the upper die into the waiting position and moving the position of the workpiece relative to the machine bed in at least one infeed direction are performed repetitively. Before the workpiece is formed into the final shape, a filling element, which is adapted to the mould recess and designed to make up the material thickness, is produced and is arranged in the region of the mould recess. An arrangement is also provided.

Abstract: The present disclosure relates to an injection device. The injection device comprises a body for holding a syringe that has a needle at one end and a cap that is removably attached to the body. The cap has a needle shield to cover said needle. The injection device further comprises a gear assembly comprising a first rotary gear and a first linear gear to engage with the first rotary gear. The gear assembly is configured such that rotation of the first rotary gear drives the first linear gear to urge the needle shield away from the body. An actuator is provided that is configured to rotate the first rotary gear.

Abstract: The present disclosure relates to a drug delivery device that has a housing and a cap. The drug delivery device also has a lock that prevents the cap being fully replaced on the housing after the cap has been removed.

Abstract: A computer-implemented method for performing data integration, the method comprising establishing a connection between a first application and a first remote database, wherein the connection is established using a connection file containing metadata required to establish the connection, requesting, by the first application, data from the first remote database that stores the data in a first format, wherein the metadata is used to determine whether the first application is authorized to access the data in the first remote database, importing the data in the first format from the first remote database, converting, by the first application, the data in the first format to data in a native format that is specific to the first application, and providing the data in the native format to a user of the first application.

Abstract: A method for producing bead foams from foam beads based on thermoplastic elastomers, especially thermoplastic polyurethane, comprises foam beads being wetted with a polar liquid and joined together thermally in a mold via high-frequency electromagnetic radiation, especially microwave radiation, and also the bead foams obtainable therefrom.

Abstract: A storage device for storing a plurality of auto-injectors, the device configured to activate an auto-injector upon removal of the auto-injector from the device.