Patents by Inventor Michael-Harold Rock

Michael-Harold Rock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of citalopram
    Patent number: 6420574
    Abstract: The present invention relates to a method for the preparation of citalopram comprising reaction a compound of formula (I) with a compound having the formula wherein X is a suitable leaving group and R is —CH2—O—Pg, —CH2—NPg1Pg2, —CO—N(CH3)2, —CH(OR1)(OR2), —C(OR4)(OR5)(OR6), —COOR3, —CH2—CO—NH2, —CH═CHR7 and —CONHR8, wherein Pg is a protection group for an alcohol group, Pg1 and Pg2 are protection groups for an amino group, R1 and R2 are independently selected from alkyl, alkenyl, alkynyl and optionally alkyl substituted aryl or aralkyl groups or R1 and R2 together form a chain of 2 to 4 carbon atoms, each of R3, R4, R5, R6 and R7 are independently selected from alkyl, alkenyl, alkynyl and optionally alkyl substituted aryl or aralkyl and R8 is hydrogen or methyl; to form a compound of the formula wherein R is as defined above; followed by conversion of the R gro
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: July 16, 2002
    Assignee: H. Lundbeck A/S
    Inventors: Hans Petersen, Michael Harold Rock, Haleh Ahmadian
  • Method for the preparation of citalopram
    Publication number: 20020077353
    Abstract: Method for the preparation of citalopram comprising reaction of a compound of Formula (IV) 1
    Type: Application
    Filed: November 6, 2001
    Publication date: June 20, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Hans Petersen, Michael Harold Rock, Henrik Svane
  • Method for the preparation of citalopram
    Patent number: 6407267
    Abstract: A method for the preparation of citalopram comprising reaction of a compound of Formula (IV), wherein R is C1-6 alkyl, acyl, C1-6 alkylsulfonyl or arylsulfonyl, with 3-(N,N-dimethylamino)-propyl magnesium halide, to prepare citalopram.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: June 18, 2002
    Assignee: H. Lundbeck A/S
    Inventors: Michael Harold Rock, Hans Petersen, Peter Ellegaard
  • Arylsulfonamides and analogues
    Publication number: 20020072529
    Abstract: The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy and craniocerebral trauma.
    Type: Application
    Filed: June 11, 2001
    Publication date: June 13, 2002
    Inventors: Joachim Mittendorf, Jurgen Dressel, Michael Matzke, Jorg Keldenich, Klaus-Helmut Mohrs, Siegfried Raddatz, Jurgen Franz, Peter Spreyer, Verena Vohringer, Joachim Schuhmacher, Michael-Harold Rock, Ervin Horvath, Arno Friedl, Frank Mauler, Jean Marie Viktor de Vry, Reinhard Jork
  • Method for the preparation of citalopram
    Publication number: 20020061925
    Abstract: Method for the preparation of citalopram comprising reaction of a compound of Formula (IV) 1
    Type: Application
    Filed: November 6, 2001
    Publication date: May 23, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Hans Petersen, Michael Harold Rock
  • Method for the preparation of citalopram
    Publication number: 20020035277
    Abstract: A method for the preparation of citalopram comprising reaction of a compound of Formula (IV), 1
    Type: Application
    Filed: June 25, 2001
    Publication date: March 21, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Michael Harold Rock, Hans Petersen, Peter Ellegaard
  • Method for the preparation of citalopram
    Publication number: 20020004604
    Abstract: A method for the preparation of citalopram wherein the aldehyde of formula 1
    Type: Application
    Filed: February 26, 2001
    Publication date: January 10, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Hans Petersen, Michael Harold Rock
  • Method for the preparation of citalopram
    Publication number: 20010027256
    Abstract: The present invention relates to a method for the preparation of citalopram comprising reaction a compound of formula (I) 1
    Type: Application
    Filed: February 26, 2001
    Publication date: October 4, 2001
    Applicant: H. Lundbeck A/S
    Inventors: Hans Petersen, Michael Harold Rock, Haleh Ahmadian
  • Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases
    Patent number: 6262112
    Abstract: The present invention relates to new aryl ether sulphonamides and analogs, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy and craniocerebral trauma.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: July 17, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Mittendorf, Jürgen Dressel, Michael Matzke, Jörg Keldenich, Klaus-Helmut Mohrs, Siegfried Raddatz, Jürgen Franz, Peter Spreyer, Verena Vöhringer, Joachim Schuhmacher, Michael-Harold Rock, Ervin Horváth, Arno Friedl, Frank Mauler, Jean Marie Viktor de Vry, Reinhard Jork
  • Method for producing aromatic nitriles
    Patent number: 6162942
    Abstract: A process for preparing aromatic nitriles from corresponding chloroaromatics by reaction with cyanides.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: December 19, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael-Harold Rock, Albrecht Marhold
  • Process for preparing pentafluoropentanol
    Patent number: 6002053
    Abstract: 4,4,5,5,5-Pentafluoro-1-pentanol is prepared in a particularly advantageous manner from perfluoroethyl iodide by initially adding perfluoroethyl iodide in the presence of a radical initiator which does not carry any acyl groups to allyl alcohol and then hydrogenolytically dehalogenating the resulting 4,4,5,5,5-pentafluoro-2-iodo-1-pentanol in the presence of a catalyst, an acid binder and a diluent.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: December 14, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael-Harold Rock, Albrecht Marhold
  • Process for preparing o-alkylfluorobenzenes
    Patent number: 5874656
    Abstract: o-Alkylfluorobenzenes are advantageously prepared by heating the corresponding chloroformates to from 70.degree. to 200.degree. C. in the liquid phase in the presence of hydrogen fluoride and in the presence of an inert diluent other than a halogenated alkane.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: February 23, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Norbert Lui, Michael-Harold Rock