Abstract: In an embodiment, one general aspect includes a method of cryptographically proving a time of signature. The method includes receiving an electronically signed digital document. The method also includes generating a cryptographic hash using at least a portion of the electronically signed digital document. The method also includes storing the cryptographic hash on a blockchain in a blockchain transaction. The method also includes storing, in association with the electronically signed digital document, a certification of an existence of the electronically signed digital document at a time associated with the blockchain transaction.

Abstract: A power converter (for example, an unregulated isolated DC-DC converter) and method that may account for low-Q resonant operation rather than conventional high-Q approximations. The converter may include primary and secondary half-bridge circuits coupled through a high-frequency transformer, with a resonant tank formed by transformer leakage inductance, parasitic resistance, and output capacitance. Time-domain analysis may model parasitic resistance effects, enabling accurate calculation of component values for achieving zero-voltage and zero-current switching. The methodology may minimize yearly average power loss (for example, rather than peak efficiency), making it particularly suitable for applications with intermittent loading such as line-frequency transformer replacements.

Abstract: In an embodiment, a method of blockchain-enhanced proof of identity (POI) includes receiving identity information of a user in connection with a POI request. The method also includes generating a first cryptographic hash using at least a portion of the identity information and storing the first cryptographic hash on a public blockchain in a first blockchain transaction. The method also includes establishing a request identifier based on the first blockchain transaction. The method also includes receiving a digital image that depicts the user together with a POI document, the digital image including the request identifier. The method also includes creating a POI digital document comprising at least a portion of the digital image. The method also includes generating a second cryptographic hash using at least a portion of the POI digital document and storing the second cryptographic hash on the public blockchain in a second blockchain transaction.

Abstract: A system and a method are disclosed for forming an anastomosis between a first layer of tissue and a second layer of tissue of a patient's body. The system includes a first anastomosis device component and a second anastomosis device component configured to interact with the first anastomosis device component. The first anastomosis device component is configured to be delivered to a first lumen inside the patient's body. The second anastomosis device component is configured to be delivered to a second lumen inside the patient's body. The second anastomosis device includes one or more sensors configured to capture sensor data for determining an alignment of the second anastomosis device component relative to the first anastomosis device component, or for characterizing the position or orientation of the second anastomosis device component in three-dimensional space.

Abstract: Disclosed are devices, systems, methods, and computer program products for orchestrating personalized therapy order management, including managing treatment workflows.

Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.

Abstract: Tissue force displacement data can be used to evaluate the suitability of a subject for an apnea therapy, such as therapy with an implanted magnet. A method of evaluating a suitability of a subject for an apnea therapy comprises placing an engagement structure on a tissue of the subject to engage the tissue of the subject. The engagement structure is moved toward the tissue to a location to move the tissue. One or more of the location or a force to the engagement structure at the location is measured. The suitability of the of the subject for the apnea therapy is determined in response to the force at the location.

Abstract: A system and a method are disclosed for forming an anastomosis between a first layer of tissue and a second layer of tissue of a patient's body. The system includes a first anastomosis device component and a second anastomosis device component configured to interact with the first anastomosis device component. The first anastomosis device component is configured to be delivered to a first lumen inside the patient's body. The second anastomosis device component is configured to be delivered to a second lumen inside the patient's body. The second anastomosis device includes one or more sensors configured to capture sensor data for determining an alignment of the second anastomosis device component relative to the first anastomosis device component, or for characterizing the position or orientation of the second anastomosis device component in three-dimensional space.

Abstract: In an embodiment, a method of blockchain-enhanced proof of identity (POI) includes receiving identity information of a user in connection with a POI request. The method also includes generating a first cryptographic hash using at least a portion of the identity information and storing the first cryptographic hash on a public blockchain in a first blockchain transaction. The method also includes establishing a request identifier based on the first blockchain transaction. The method also includes receiving a digital image that depicts the user together with a POI document, the digital image including the request identifier. The method also includes creating a POI digital document comprising at least a portion of the digital image. The method also includes generating a second cryptographic hash using at least a portion of the POI digital document and storing the second cryptographic hash on the public blockchain in a second blockchain transaction.

Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.

Abstract: In an embodiment, a method of blockchain-enhanced proof of identity (POI) includes receiving identity information of a user in connection with a POI request. The method also includes generating a first cryptographic hash using at least a portion of the identity information and storing the first cryptographic hash on a public blockchain in a first blockchain transaction. The method also includes establishing a request identifier based on the first blockchain transaction. The method also includes receiving a digital image that depicts the user together with a POI document, the digital image including the request identifier. The method also includes creating a POI digital document comprising at least a portion of the digital image. The method also includes generating a second cryptographic hash using at least a portion of the POI digital document and storing the second cryptographic hash on the public blockchain in a second blockchain transaction.

Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.

Abstract: A system and a method are disclosed for forming an anastomosis between a first layer of tissue and a second layer of tissue of a patient's body. The system includes a first anastomosis device component and a second anastomosis device component configured to interact with the first anastomosis device component. The first anastomosis device component is configured to be delivered to a first lumen inside the patient's body. The second anastomosis device component is configured to be delivered to a second lumen inside the patient's body. The second anastomosis device includes one or more sensors configured to capture sensor data for determining an alignment of the second anastomosis device component relative to the first anastomosis device component, or for characterizing the position or orientation of the second anastomosis device component in three-dimensional space.

Abstract: A system and a method are disclosed for forming an anastomosis between a first layer of tissue and a second layer of tissue of a patient's body. The system includes a first anastomosis device component and a second anastomosis device component configured to interact with the first anastomosis device component. The first anastomosis device component is configured to be delivered to a first lumen inside the patient's body. The second anastomosis device component is configured to be delivered to a second lumen inside the patient's body. The second anastomosis device includes one or more sensors configured to capture sensor data for determining an alignment of the second anastomosis device component relative to the first anastomosis device component, or for characterizing the position or orientation of the second anastomosis device component in three-dimensional space.

Abstract: A system and a method are disclosed for forming an anastomosis between a first layer of tissue and a second layer of tissue of a patient's body. The system includes a first anastomosis device component and a second anastomosis device component configured to interact with the first anastomosis device component. The first anastomosis device component is configured to be delivered to a first lumen inside the patient's body. The second anastomosis device component is configured to be delivered to a second lumen inside the patient's body. The second anastomosis device includes one or more sensors configured to capture sensor data for determining an alignment of the second anastomosis device component relative to the first anastomosis device component, or for characterizing the position or orientation of the second anastomosis device component in three-dimensional space.

Abstract: A method and apparatus for voltage clamping including: measuring a DC voltage across the PV module at an input of a power converter, comparing the measured DC voltage to the overvoltage threshold, determining the measured DC voltage exceeds the overvoltage threshold, and operating a clamping circuit to clamp at least a portion of the DC voltage prior to input to the power converter.

Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.

Abstract: Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.

Abstract: An embodiment of the present invention is directed to an integrated electromagnetic compatibility (EMC) filter and power line communication (PLC) interface. The EMC filter and PLC interface comprises a first filter winding and a second filter winding configured as a common mode choke; and a two-part winding on the common mode choke, wherein the two-part winding comprises (i) a first winding coupled proximate the first filter winding and (ii) a second winding coupled proximate the second filter winding, wherein the first winding and the second winding have an equal number of turns, and wherein phasing of the first winding is reversed with respect to the second winding.