Abstract: A system for irradiation of a vascular space and its contents is presented. An adapter device having a vascular access end and an optical interface end can include a waveguide affixed within a waveguide lumen and extending outwardly through the vascular access end. The optical interface end includes a tapered terminus configured to engage with a cavity of an optical connector adapter, creating an optical interface between the waveguide of the adapter device and a waveguide of a light or radiation source. The adapter device enables the simultaneous administration of radiation and exogenous fluids to a patient while maintaining the optical interface isolated from any fluids.

Abstract: An optical device for illuminating the vasculature of a mammal using ultraviolet, visible, and/or infrared light is described. The optical device includes an optical fiber encased in a biocompatible sheath, and is dimensioned to lie within an intravascular catheter. When placed within a vascular space and coupled with a suitable light source the optical device illuminates the vascular space and its contents. The faces of the optical fiber are configured to optimize the capture of ultraviolet, visible, and/or infrared light from a light source without the use of active optics.

Abstract: A system for irradiation of a vascular space and its contents is presented. An adapter device having a vascular access end and an optical interface end can include a waveguide affixed within a waveguide lumen and extending outwardly through the vascular access end. The optical interface end includes a tapered terminus configured to engage with a cavity of an optical connector adapter, creating an optical interface between the waveguide of the adapter device and a waveguide of a light or radiation source. The adapter device enables the simultaneous administration of radiation and exogenous fluids to a patient while maintaining the optical interface isolated from any fluids.

Abstract: The present invention provides for a fuel piping arrangement in common rail type fuel supply systems, the supply system comprising at least one common rail and at least one respective injector, wherein the common rail is connected with the at least one injector directly, by means of only one joint.

Abstract: An optical device for illuminating the vasculature of a mammal using ultraviolet, visible, and/or infrared light is described. The optical device includes an optical fiber encased in a biocompatible sheath, and is dimensioned to lie within an intravascular catheter. When placed within a vascular space and coupled with a suitable light source the optical device illuminates the vascular space and its contents. The faces of the optical fiber are configured to optimize the capture of ultraviolet, visible, and/or infrared light from a light source without the use of active optics.

Abstract: A system for irradiation of a vascular space and its contents is presented. An adapter device having a vascular access end and an optical interface end can include a waveguide affixed within a waveguide lumen and extending outwardly through the vascular access end. The optical interface end includes a tapered terminus configured to engage with a cavity of an optical connector adapter, creating an optical interface between the waveguide of the adapter device and a waveguide of a light or radiation source. The adapter device enables the simultaneous administration of radiation and exogenous fluids to a patient while maintaining the optical interface isolated from any fluids.

Abstract: A system for irradiation of a vascular space and its contents is presented. An adapter device having a vascular access end and an optical interface end can include a waveguide affixed within a waveguide lumen and extending outwardly through the vascular access end. The optical interface end includes a tapered terminus configured to engage with a cavity of an optical connector adapter, creating an optical interface between the waveguide of the adapter device and a waveguide of a light or radiation source. The adapter device enables the simultaneous administration of radiation and exogenous fluids to a patient while maintaining the optical interface isolated from any fluids.

Abstract: Systems and methods for illumination of a vascular space and its contents using an electromagnetic energy source that supplies a plurality of wavelengths ranging from ultraviolet to infrared are shown. Illumination can be performed using multiple wavelengths, simultaneously or sequentially, and can be performed in accordance with a protocol where an initial illumination produces an effect that is at least partially reversed by a subsequent illumination. Illumination protocols can be stored on a database and accessed via a user interface displayed on the electromagnetic energy source. The database can be used to store data related to performance of system components, and such data can be used to override or modify an illumination protocol.

Abstract: A fluid friction clutch includes a drivable housing having a working chamber and a reservoir, at least one opening between the reservoir and the working chamber configured to provide fluid communication between the reservoir and the working chamber, a driven disk supported for rotation in the working chamber, and a rotor mounted in the reservoir and rotatably coupled to the driven disk for rotation about an axis of rotation, the rotor having a plurality of arms, separated by a plurality of gaps, projecting away from its axis of rotation.

Abstract: The present invention provides for a fuel piping arrangement in common rail type fuel supply systems, the supply system comprising at least one common rail and at least one respective injector, wherein the common rail is connected with the at least one injector directly, by means of only one joint.

Abstract: Systems and methods for illumination of a vascular space and its contents using an electromagnetic energy source that supplies a plurality of wavelengths ranging from ultraviolet to infrared are shown. Illumination can be performed using multiple wavelengths, simultaneously or sequentially, and can be performed in accordance with a protocol where an initial illumination produces an effect that is at least partially reversed by a subsequent illumination. Illumination protocols can be stored on a database and accessed via a user interface displayed on the electromagnetic energy source. The database can be used to store data related to performance of system components, and such data can be used to override or modify an illumination protocol.

Abstract: An optical device for illuminating the vasculature of a mammal using ultraviolet, visible, and/or infrared light is described. The optical device includes an optical fiber encased in a biocompatible sheath, and is dimensioned to lie within an intravascular catheter. When placed within a vascular space and coupled with a suitable light source the optical device illuminates the vascular space and its contents. The faces of the optical fiber are configured to optimize the capture of ultraviolet, visible, and/or infrared light from a light source without the use of active optics.

Abstract: A system for irradiation of a vascular space and its contents is presented. An adapter device having a vascular access end and an optical interface end can include a waveguide affixed within a waveguide lumen and extending outwardly through the vascular access end. The optical interface end includes a tapered terminus configured to engage with a cavity of an optical connector adapter, creating an optical interface between the waveguide of the adapter device and a waveguide of a light or radiation source. The adapter device enables the simultaneous administration of radiation and exogenous fluids to a patient while maintaining the optical interface isolated from any fluids.

Abstract: A fluid friction clutch includes a drivable housing having a working chamber and a reservoir, at least one opening between the reservoir and the working chamber configured to provide fluid communication between the reservoir and the working chamber, a driven disk supported for rotation in the working chamber, and a rotor mounted in the reservoir and rotatably coupled to the driven disk for rotation about an axis of rotation, the rotor having a plurality of arms, separated by a plurality of gaps, projecting away from its axis of rotation.

Abstract: The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the treatment of cardiovascular and other diseases. Such compounds, processes for preparing them, compositions containing them, and methods of using them are claimed.

Abstract: The present invention relates to phenylacetamides, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, especially of cardiovascular disorders.

Abstract: This invention relates to methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis, comprising administering an effective amount of a compound of formula (I) in which the several variables are as defined in the specification and claims.

Abstract: The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.

Abstract: The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the treatment of cardiovascular and other diseases. Such compounds, processes for preparing them, compositions containing them, and methods of using them are claimed.