Abstract: Disclosed herein are compositions comprising AAV9 viral vectors and methods of using them to treat SMA patients, e.g., Type II and Type III Spinal Muscular Atrophy (SMA) patients.

Abstract: Methods for preparing and purifying viral particles, and compositions and uses comprising the same, are provided.

Abstract: The present disclosure relates to system for controlling operation of machine. The system includes fatigue detection unit configured to generate a signal indicative of fatigue parameter of an operator of the machine. The system includes proximity sensing unit to capture image of a surrounding area of the machine. The system further includes a controller, configured to determine fatigue condition of the operator and to detect presence of an obstacle in the surrounding area of the machine. The controller is further configured to generate a warning signal based on the fatigue condition of the operator and the captured image of the surrounding area of the machine. The controller is configured to communicate signal indicative of the action of the operator with a control module of the machine. The control module autonomously control operation of the machine based on a signal indicative of the action of the operator.

Abstract: Systems and methods for optimizing worksite operations based on operator conditions are disclosed. One method includes receiving first data including one or more of a worksite model and information relating to actual operation of a worksite, wherein the worksite model includes a simulated operation of a machine associated with the worksite. Second data may be received, the second data associated with an operator of a machine at the worksite and including one or more of nutritional data, health data, and sleep data. An operation state may be determined based at least on the first data and the second data. A response may be generated based at least on the determined operation state.

Abstract: Systems and methods for optimizing worksite operations based on operator conditions are disclosed. One method includes receiving first data including one or more of a worksite model and information relating to actual operation of a worksite, wherein the worksite model includes a simulated operation of a machine associated with the worksite. Second data may be received, the second data associated with an operator of a machine at the worksite and including one or more of nutritional data, health data, and sleep data. An operation state may be determined based at least on the first data and the second data. A response may be generated based at least on the determined operation state.