Abstract: This invention relates to novel detergent compositions comprising bacterial mannanase enzymes. The detergent compositions comprising bacterial mannanases are useful in laundry and cleaning applications wherein degradation or modification of mannan is desired. The invention also relates to the use of said detergent compositions in laundry and cleaning applications as well as a method for degrading mannan.

Abstract: This present disclosure relates to novel detergent compositions comprising bacterial mannanase enzymes. The detergent compositions comprising bacterial mannanases are useful in laundry and cleaning applications wherein degradation or modification of mannan is desired. The present disclosure also relates to the use of said detergent compositions in laundry and cleaning applications as well as a method for degrading mannan.

Abstract: A method for generating a magnetic resonance image includes providing MR segment data records, wherein each MR segment data record has N×M frequency voxels in k-space. To reduce the acquisition time during MR segment recordings, the amount of MR data is reduced by incompletely sampling the k-space during a recording. The missing data of the MR segment data records are reconstructed twice: Preliminarily reconstructed MR segment data records are calculated first, with a reconstruction kernel obtained from reference data. Modified reference images containing phase information are obtained by creating phase images from the preliminarily reconstructed MR segment data records and combining these phase images with the absolute value of the reference image generated from the reference data. The second reconstruction kernels are ascertained therefrom in turn. In contrast to the first reconstruction kernel, these contain phase information, such that the missing data can be reconstructed without phase artifacts.

Abstract: A method for generating a magnetic resonance image includes providing MR segment data records, wherein each MR segment data record has N×M frequency voxels in k-space. To reduce the acquisition time during MR segment recordings, the amount of MR data is reduced by incompletely sampling the k-space during a recording. The missing data of the MR segment data records are reconstructed twice: Preliminarily reconstructed MR segment data records are calculated first, with a reconstruction kernel obtained from reference data. Modified reference images containing phase information are obtained by creating phase images from the preliminarily reconstructed MR segment data records and combining these phase images with the absolute value of the reference image generated from the reference data. The second reconstruction kernels are ascertained therefrom in turn. In contrast to the first reconstruction kernel, these contain phase information, such that the missing data can be reconstructed without phase artifacts.

Abstract: A method for establishing and/or reducing artifacts that arise when reconstructing (R) an MPI overall image data record from MPI signal data and an appended system matrix (SMapp(r,f)), wherein the appended system matrix (SMapp(r,f)) includes system matrices of different particle classes (P1, P2). The method includes setting a selection region (cvn(r)) of a reconstructed MPI overall image data record (cn(r)), producing virtual signal data (sn(f)) by inverse transformation of the selection region, reconstructing a virtual overall image data record (c?vn(r)) from the virtual signal data and the appended system matrix, setting an artifact region (cartifact_n(r)) within the reconstructed virtual overall image data record so that the artifact region has only voxels lying outside of the selection region, and assigning the image data present in the artifact region as artifact image data (cartifact_n(r)). This permits ghost artifacts to be corrected.

Abstract: A method for establishing a local concentration distribution of magnetic particles of at least one particle class within an examination volume or a variable derived from this concentration distribution. The method includes providing at least one system matrix, providing MPI signal data of at least one sample including magnetic particles of at least one particle class within a measurement volume, and reconstructing spatially resolved MPI image data from the provided MPI signal data. At least one spatial projection of at least one part of the system matrix is carried out along a projection direction and a projected system matrix is generated thereby. The reconstruction of the MPI image data is implemented with the at least partly projected system matrix, as a result of which MPI image data of a spatial projection of the local concentration distribution of the magnetic particles are produced along the projection direction.

Abstract: The systems, methods, and devices described herein generally relate to achieving accurate and robust motion correction by detecting and accounting for false movements in motion correction systems used in conjunction with medical imaging and/or therapeutic systems. In other words, in some embodiments of the systems, methods, and devices described herein can be configured to detect false movements for motion correction during a medical imaging scan and/or therapeutic procedure, and thereby ensure that such false movements are not accounted for in the motion correction process. Upon detection of false movements, the imaging or therapeutic system can be configured to transiently suppress and/or subsequently repeat acquisitions.

Abstract: A method for establishing a local concentration distribution of magnetic particles of at least one particle class within an examination volume or a variable derived from this concentration distribution. The method includes providing at least one system matrix, providing MPI signal data of at least one sample including magnetic particles of at least one particle class within a measurement volume, and reconstructing spatially resolved MPI image data from the provided MPI signal data. At least one spatial projection of at least one part of the system matrix is carried out along a projection direction and a projected system matrix is generated thereby. The reconstruction of the MPI image data is implemented with the at least partly projected system matrix, as a result of which MPI image data of a spatial projection of the local concentration distribution of the magnetic particles are produced along the projection direction.

Abstract: A method for establishing and/or reducing artifacts that arise when reconstructing (R) an MPI overall image data record from MPI signal data and an appended system matrix (SMapp(r,f)), wherein the appended system matrix (SMapp(r,f)) includes system matrices of different particle classes (P1, P2). The method includes setting a selection region (cvn(r)) of a reconstructed MPI overall image data record (cn(r)),producing virtual signal data (sn(f)) by inverse transformation of the selection region, reconstructing a virtual overall image data record (c?vn(r)) from the virtual signal data and the appended system matrix, setting an artifact region (cartifact_n(r)) within the reconstructed virtual overall image data record so that the artifact region has only voxels lying outside of the selection region, and assigning the image data present in the artifact region as artifact image data (Cartifact_n(r)). This permits ghost artifacts to be corrected.

Abstract: The systems, methods, and devices described herein generally relate to achieving accurate and robust motion correction by detecting and accounting for false movements in motion correction systems used in conjunction with medical imaging and/or therapeutic systems. In other words, in some embodiments of the systems, methods, and devices described herein can be configured to detect false movements for motion correction during a medical imaging scan and/or therapeutic procedure, and thereby ensure that such false movements are not accounted for in the motion correction process. Upon detection of false movements, the imaging or therapeutic system can be configured to transiently suppress and/or subsequently repeat acquisitions.

Abstract: The systems, methods, and devices described herein generally relate to achieving accurate and robust motion correction by detecting and accounting for false movements in motion correction systems used in conjunction with medical imaging and/or therapeutic systems. In other words, in some embodiments of the systems, methods, and devices described herein can be configured to detect false movements for motion correction during a medical imaging scan and/or therapeutic procedure, and thereby ensure that such false movements are not accounted for in the motion correction process. Upon detection of false movements, the imaging or therapeutic system can be configured to transiently suppress and/or subsequently repeat acquisitions.

Abstract: The systems, methods, and devices described herein generally relate to achieving accurate and robust motion correction by detecting and accounting for false movements in motion correction systems used in conjunction with medical imaging and/or therapeutic systems. In other words, in some embodiments of the systems, methods, and devices described herein can be configured to detect false movements for motion correction during a medical imaging scan and/or therapeutic procedure, and thereby ensure that such false movements are not accounted for in the motion correction process. Upon detection of false movements, the imaging or therapeutic system can be configured to transiently suppress and/or subsequently repeat acquisitions.

Abstract: A method of MR imaging and spectroscopy to reduce artifacts occurring due to the motion of an object to be represented, wherein the object position is determined quasi-continuously during the runtime of the MR acquisition, which includes one or more partial acquisitions (TA), and wherein motion correction is performed, which comprises dynamic adaptation of the frequency and phase settings of the RF system of the tomograph and of the orientation and amplitudes of the gradients during the runtime of the MR acquisition according to the current object position. The motion correction is thereby applied during a signal weighting period, during a signal read-out period, or between and/or during the two stated periods and the adaptations for motion correction are performed without interrupting or slowing the temporal progression of the MR acquisition. In this way, artifacts due to motion of the object to be represented can be further reduced.

Abstract: A method of MR imaging and spectroscopy reduces artifacts occurring due to the motion of an object to be represented, wherein the object position is determined quasi-continuously during the runtime of the MR acquisition, which includes one or more partial acquisitions (TA), and wherein motion correction is performed, which comprises dynamic adaptation of the frequency and phase settings of the RF system of the tomograph and of the orientation and amplitudes of the gradients during the runtime of the MR acquisition according to the current object position. The motion correction is thereby applied during a signal weighting period, during a signal read-out period, or between and/or during the two stated periods and the adaptations for motion correction are performed without interrupting or slowing the temporal progression of the MR acquisition. In this way, artifacts due to motion of the object to be represented can be further reduced.

Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject.