Abstract: An integrated digital play system made according to the present invention provides a multi media, digitally integrated play environment that incorporates mobile device content and web based content which interacts with physically installed tags. The system includes means for identifying a fixed physical structure within a first play system; means for detecting a physical movement of a user relative to the fixed physical structure; a first computer means for combining the physical structure identification data and the user physical movement data to generate one or more motion points; and a second computer means for providing a virtual embodiment of the one or more motion points within a second play system. Because the first and second play systems are different play systems, the second play system does not require certain corresponding user motions in the first play system in order to perform in or progress through the second play system.

Abstract: An integrated digital play system made according to the present invention provides a multi media, digitally integrated play environment that incorporates mobile device content and web based content which interacts with physically installed tags. The system includes means for identifying a fixed physical structure within a first play system; means for detecting a physical movement of a user relative to the fixed physical structure; a first computer means for combining the physical structure identification data and the user physical movement data to generate one or more motion points; and a second computer means for providing a virtual embodiment of the one or more motion points within a second play system. Because the first and second play systems are different play systems, the second play system does not require certain corresponding user motions in the first play system in order to perform in or progress through the second play system.

Abstract: A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about 12 mg.

Abstract: A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.

Abstract: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.

Abstract: A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about 12 mg.

Abstract: The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.

Abstract: The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.