Patents by Inventor Michael Hiles
Michael Hiles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11771543Abstract: In various embodiments, the present invention is directed to a degradable poly(ester urea) (PEU)-based adhesion barrier, particularly suitable for use in connection with surgical mesh repair in the treatment of hernias and other soft tissue injuries comprising an amino acid based poly(ester urea) backbone and one or more zwitterionic side chains connected to the amino acid based poly(ester urea) backbone through a sulfide bond. In some other embodiments, the present invention is directed to method of making the PEU-based adhesion barriers comprising: preparing an amino acid based PEU polymer or terpolymer having one or more allyl functional groups; preparing a thiol functionalized zwitterionic compound; and reacting the allyl functionalized PEU polymer or terpolymer with the thiol functionalized zwitterionic compound to form a degradable PEU-based adhesion barrier having an amino acid based PEU backbone having zwitterionic side chains.Type: GrantFiled: May 7, 2019Date of Patent: October 3, 2023Assignees: The University of Akron, Cook Medical Technologies LLCInventors: Matthew Becker, Nathan Z. Dreger, Zachary K. Zander, Trenton Parsell, Michael Hiles
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Publication number: 20230240838Abstract: Medical devices for repairing defects in tissue, such as perforations in the tympanic membrane of an animal, methods of manufacturing medical devices, methods of implanting a medical device in a defect in a tissue; and methods of repairing a defect in a tissue are described. In one form, a medical device includes an overlay member having multiple arms and defining an overlay member passageway, an underlay member having multiple flaps and defining an underlay member passageway, and a securement member extending through the overlay member passageway and the underlay member passageway. In methods, the multiple flaps of the underlay member can be sequentially advanced into a defect in a tissue, such as a perforation in a tympanic membrane of an animal.Type: ApplicationFiled: January 27, 2023Publication date: August 3, 2023Applicants: Cook Medical Technologies LLC, Cook Biotech IncorporatedInventors: Alycia Berman, Alex Brethauer, Christopher A. Carruthers, Michelle Chutka, Alex de Poix, Shaun Davis Gittard, Katie Herget, Michael Hiles, George Malinee, Elena Monroe, Bhavin B. Shah, Brayden Smith
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Publication number: 20230228202Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to implement a stator plenum with collet seal. The stator plenum for a gas turbine engine includes an outer shell circumscribing a centerline axis, a first end of the outer shell coupled to an engine casing at a first coupling, the first coupling to form a first seal, a second end of the outer shell coupled to the engine casing at a second coupling, the second end formed by a thickened portion of the outer shell, the second coupling to form a second seal, and a cavity formed by the outer shell, the cavity to contain cooling flow to reduce a temperature of a turbine.Type: ApplicationFiled: January 20, 2022Publication date: July 20, 2023Inventors: Travis J. Packer, Michael A. Hile, James H. Grooms
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Publication number: 20210212807Abstract: In various embodiments, the present invention is directed to a degradable poly(ester urea) (PEU)-based adhesion barrier, particularly suitable for use in connection with surgical mesh repair in the treatment of hernias and other soft tissue injuries comprising an amino acid based poly(ester urea) backbone and one or more zwitterionic side chains connected to the amino acid based poly(ester urea) backbone through a sulfide bond. In some other embodiments, the present invention is directed to method of making the PEU-based adhesion barriers comprising: preparing an amino acid based PEU polymer or terpolymer having one or more allyl functional groups; preparing a thiol functionalized zwitterionic compound; and reacting the allyl functionalized PEU polymer or terpolymer with the thiol functionalized zwitterionic compound to form a degradable PEU-based adhesion barrier having an amino acid based PEU backbone having zwitterionic side chains.Type: ApplicationFiled: May 7, 2019Publication date: July 15, 2021Inventors: Matthew BECKER, Nathan Z. DREGER, Zachary K. ZANDER, Trenton PARSELL, Michael HILES
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Patent number: 9788821Abstract: Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.Type: GrantFiled: June 22, 2009Date of Patent: October 17, 2017Assignee: Cook Biotech IncorporatedInventors: Chad E. Johnson, David M. J. Ernst, Michael Hiles, F. Joseph Obermiller
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Patent number: 8790414Abstract: A graft and method of using a graft are described that should decrease the incidence of abnormal placentation and uterine rupture that result from cesarean section and restore the anatomic integrity of the uterus at a hysterotomy surgical site, while not disturbing the involution of the postpartum uterus.Type: GrantFiled: November 9, 2007Date of Patent: July 29, 2014Assignees: Cook Biotech Incorporated, Cook Medical Technologies LLCInventors: John Michael O'Brien, Jr., Daniel K. Whetham, Michael Hiles
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Patent number: 8454678Abstract: Described are preferred prosthetic valve devices including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components on the material. The cells are then removed to provide the extracellular matrix composite material. In preferred embodiments, the prosthetic valve devices are configured for use in vascular applications.Type: GrantFiled: March 17, 2006Date of Patent: June 4, 2013Assignee: Cook Biotech IncorporatedInventor: Michael Hiles
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Publication number: 20100104658Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: ApplicationFiled: October 31, 2007Publication date: April 29, 2010Applicants: Cook Biotech Incorporated, Cook Incorporated, MED Institute, Inc.Inventors: William Cook, Michael Hiles, Thomas Kozma, Umesh Patel
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Publication number: 20100106256Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: ApplicationFiled: October 31, 2007Publication date: April 29, 2010Applicants: Cook Biotech Incorporated, Cook Incorporated, MED Institute, Inc.Inventors: William Cook, Michael Hiles, Thomas Kozma, Umesh Patel
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Publication number: 20100104617Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: ApplicationFiled: October 31, 2007Publication date: April 29, 2010Applicants: Cook Biotech Incorporated, Cook Incorporated, MED Institute, Inc.Inventors: William Cook, Michael Hiles, Thomas Kozma, Umesh Patel
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Publication number: 20100106257Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: ApplicationFiled: October 31, 2007Publication date: April 29, 2010Applicants: Cook Biotech Incorporated, Cook Incorporated, MED Institute, Inc.Inventors: William Cook, Michael Hiles, Thomas Kozma, Umesh Patel
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Publication number: 20090326577Abstract: Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.Type: ApplicationFiled: June 22, 2009Publication date: December 31, 2009Inventors: Chad E. Johnson, David M.J. Ernst, Michael Hiles, F. Joseph Obermiller
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Publication number: 20080114469Abstract: A graft and method of using a graft are described that should decrease the incidence of abnormal placentation and uterine rupture that result from cesarean section and restore the anatomic integrity of the uterus at a hysterotomy surgical site, while not disturbing the involution of the postpartum uterus.Type: ApplicationFiled: November 9, 2007Publication date: May 15, 2008Applicant: Vance Products Incorporated d/b/a Cook Urological IncorporatedInventors: John Michael O'Brien, Daniel K. Whetham, Michael Hiles
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Publication number: 20080097585Abstract: Medical device valve repair systems that include a stabilization member are provided. The stabilization member includes an engaging channel to contact the engaging surface of a valve holding valve leaflets in a position such that a tissue repair device may form a coaptation between the valve leaflets.Type: ApplicationFiled: July 2, 2007Publication date: April 24, 2008Inventors: Richard Sisken, Michael Hiles, Neal Fearnot, Alan Leewood
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Publication number: 20080063680Abstract: The invention involves a submucosa tissue that has the capability of being shape formed or shape configured. The submucosa involves a purified form of submucosa tissue. Optionally, the submucosa can be packaged in such a manner to permit sterility or maintain sterility of the submucosa.Type: ApplicationFiled: October 8, 2007Publication date: March 13, 2008Inventors: Michael Hiles, Umesh Patel
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Publication number: 20080046070Abstract: Described are preferred prosthetic valve devices including an extracellular matrix (ECM) material coated with a microtubule inhibiting agent and affixed to a stent. The stent is configured such that the coated ECM material is formed into one or more leaflets. In preferred embodiments, the prosthetic valve devices are configured for use in vascular applications.Type: ApplicationFiled: March 30, 2007Publication date: February 21, 2008Inventors: F. Obermiller, Michael Hiles
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Publication number: 20080004657Abstract: Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.Type: ApplicationFiled: May 1, 2006Publication date: January 3, 2008Inventors: F. Obermiller, Michael Hiles, Matthew Graham, Clay Fette
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Publication number: 20070088391Abstract: A medical device with pre-attached affixation means placed to minimize the likelihood of adjacent tissues undesirably adhering to the affixation means. Also, methods of making and using such a device.Type: ApplicationFiled: October 13, 2006Publication date: April 19, 2007Applicant: Cook Biotech Inc.Inventors: Chad McAlexander, Michael Hiles
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Publication number: 20070082060Abstract: Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibrob-last Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.Type: ApplicationFiled: August 25, 2004Publication date: April 12, 2007Inventors: Michael Hiles, Jason Hodde, David Ernst, Lal Ninan
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Publication number: 20070037283Abstract: The invention provides tissue graft compositions comprising collagen-based extracellular matrices derived from renal capsules of warm-blooded vertebrates. The invention further provides a process of harvesting and purifying a renal capsule to provide an extracellular matrix material having beneficial use as a tissue graft and/or cell growth material.Type: ApplicationFiled: July 11, 2006Publication date: February 15, 2007Inventors: Umesh Patel, Michael Hiles, Jason Hodde