Abstract: An interstitial fluid (ISF) extraction device includes a penetration member configured for penetrating a target site of a user's skin layer and, subsequently, residing in the user's skin layer and extracting an ISF sample therefrom and at least three concentrically-arranged pressure rings, each adapted for applying pressure to the user's skin layer in the vicinity of the target site while the penetration member is residing in the user's skin layer. In addition, the ISF extraction device is configured such that (i) the pressure rings apply pressure in an oscillating manner with asymmetric deployment and retraction cycles and (ii) only one of the at least three concentrically-arranged pressure rings is deployed at a time, thereby mitigating an ISF glucose lag of the ISF sample extracted by the penetration member.

Abstract: An interstitial fluid (ISF) extraction device includes a penetration member configured for penetrating a target site of a user's skin layer and, subsequently, residing in the user's skin layer and extracting an ISF sample therefrom and at least three concentrically-arranged pressure rings, each adapted for applying pressure to the user's skin layer in the vicinity of the target site while the penetration member is residing in the user's skin layer. In addition, the ISF extraction device is configured such that (i) the pressure rings apply pressure in an oscillating manner with asymmetric deployment and retraction cycles and (ii) only one of the at least three concentrically-arranged pressure rings is deployed at a time, thereby mitigating an ISF glucose lag of the ISF sample extracted by the penetration member.

Abstract: A method for extracting interstitial fluid from a target site of a user includes adhesively attaching a floating ring of a sampling module for extracting interstitial fluid to the user in the vicinity of a target site and then mounting the sampling module to the floating ring and attaching the sampling module to the user. Subsequently, the target site is penetrated with a penetration member of the sampling module. Pressure is then applied in another vicinity of the target site by a pressure ring of the sampling module and, thereafter, ISF extracted from the target site via a penetration member of the sampling module.

Abstract: A sampling module for extracting interstitial fluid (ISF) from a user's body includes a housing assembly and a pressure ring assembly operatively contained within the housing assembly. The pressure ring assembly includes a penetration member configured for penetrating a target site of the user's body and, subsequently, residing in the target site and extracting ISF therefrom. The pressure ring assembly also includes a pressure ring configured for applying pressure to the user's body in a first vicinity of the target site and a floating ring with an adhesive layer disposed on it's distal end. The adhesive layer of the sampling module provides for adhesive attachment of the floating ring to the user's body in a second vicinity of the target site, thereby influencing target site deformation during use of the sampling module.

Abstract: A sampling apparatus for interstitial fluid includes a pressure ring surrounding a collection needle. The pressure ring and needle are movable relative to one another for the ring to first engage a patient's skin surface prior to insertion of the needle.

Abstract: Systems and methods are provided for extracting a bodily fluid sample (e.g., an interstitial fluid sample) and monitoring an analyte therein. Certain of the systems include a a penetration member configured for penetrating and residing in a target site of a user's skin layer and, subsequently, extracting a fluid sample therefrom. The system also includes a pressure ring(s) adapted for applying pressure to the user's skin layer in the vicinity of the target site. The system is configured such that the pressure ring(s) is capable of applying pressure in an oscillating manner. Certain methods include penetrating the skin and applying pressure to the skin in an oscillating manner.

Abstract: A bodily fluid extraction device includes a penetration member configured for penetrating a target site and subsequently residing within the target site and extracting a bodily fluid sample. The penetration member includes a proximal end adapted for fluid communication with an analyte analysis system, a distal end, and a channel extending from the distal to the proximal end. The distal end includes a sharp portion for penetrating a target site, and a flexible feature adapted for promoting bodily fluid flow into the channel by protruding into the target site after the penetration member has penetrated the target site. A method for extracting bodily fluid includes providing a bodily fluid extraction device as described immediately above.

Abstract: A device for extracting bodily fluid (such as an ISF sample) includes a penetration member with a channel (e.g., a hollow needle) and a fluid flow regulator (for example, a narrow-bore cylinder) disposed within the channel. The penetration member is configured for penetrating a target site (such as a dermal tissue target site) and subsequently residing within the target site and extracting a bodily fluid sample therefrom. The fluid flow regulator is adapted to control (e.g., reduce or minimize variation in) bodily fluid flow rate through the penetration member. In addition, the presence of the fluid flow regulator in the channel of the penetration member serves to reduce sensor lag by reducing the dead volume of the penetration member. A method for extracting bodily fluid from a target site includes providing the aforementioned device. Next, the target site is penetrated with the penetration member of the device.

Abstract: A system for extracting a bodily fluid sample (e.g., an interstitial fluid [ISF] sample) and monitoring an analyte therein includes a disposable cartridge and a local controller module. The disposable cartridge includes a sampling module adapted to extract a bodily fluid sample and an analysis module adapted to measure an analyte (e.g., glucose) in the bodily fluid sample. The local controller module is in electronic communication with the disposable cartridge and is adapted to receive and store measurement data from the analysis module. An ISF extraction device includes a penetration member configured for penetrating and residing in a target site of a user's skin layer and, subsequently, extracting an ISF sample therefrom. The device also includes a pressure ring(s) adapted for applying pressure to the user's skin layer in the vicinity of the target site.